Báo cáo y học: "Hypercholesterolemia and microvascular dysfunction: interventional strategies" docx

... the delicate system by pro- ducing additio nal ROS and inflammatory recruitment [68,71]. Hypercholesterolemia and Pharmaceutical Therapies Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) ... reduce LDL blood cholesterol levels by 60% while concurrently raising HDL levels and limiting liver toxicity, myotoxicity and/ or rhabdomyolysis traditionally caused by statin treatment al...

Ngày tải lên: 11/08/2014, 03:20

... glomerulopathy leading toward kidney dysfunction and hypertension, reductions in coronary flow reserve leading to an early coronary heart disease and hepatic dysfunction leading toward non-alcoholic fatty ... IL-6, may e xacerbate vascu- lar dysfunc tion by inhibiting eNOS, stimulating produc- tion of reactive oxygen species and increasing vascular permeability, and may also initiate...

Ngày tải lên: 11/08/2014, 06:22

... by JHT, MM, JSD and DPS. The data was processed by JSD and MM, and was analysed by JSD with help from ACC, TWY and NMA. Labo- ratory sample processing and HPLC assays were performed by CJD and ... University of Sydney and Department of Cardiology, Royal Prince Alfred Hospital, Missenden Road, Sydney, NSW 2006, Australia Corresponding author: Nicholas M Anstey, Nicholas.Anstey@m...

Ngày tải lên: 13/08/2014, 19:20

... defi nitive studies are awaited, and they may be tagged by SNP studies anyway [4]. Most heritability studies report narrow-sense heritability, which is heritability excluding gene–gene interaction; ... an unlikely source of much missing heritability. Of the 95 loci known by SNP studies at the end of 2009 to be associated with Crohn’s disease and type 1 and type 2 diabetes, only thr...

Ngày tải lên: 12/08/2014, 15:22

... (CD8-PerCP) (BD Immunocytometry Systems, San Jose, CA), and CD56-allo- phycocyanin (CD56-APC) (Immunotech, Brea, CA). Red cells were then lysed with FACSlyse (BD Immunocytometry Table 1 Clinical ... cytotoxicity receptors [38]. Figure 3 Flow cytometric analysis of perforin expression in NK cells and cyto-toxic CD8 + cellsFlow cytometric analysis of perforin expression in NK cells and c...

Ngày tải lên: 09/08/2014, 06:22

... laboratory testing. Cytokines and adhesion mole- cules were measured using enzyme-linked immunosorbent assays (Hiss Diagnostics GmbH, Freiburg, Switzerland). The intra-assay and inter-assay coefficients ... (respec- tively) were 5.1% and 8.6% for IL-1, 3.4% and 5.2% for IL-6, 6.9% and 7.4% for TNF-α, 3.1% and 5.2% for VCAM-1, 4.1% and 7.7% for ICAM-1, and 5.4% and 6.0% for E...

Ngày tải lên: 09/08/2014, 06:22

... purposes) Pathophysiology of DD and its consequencesFigure 1 Pathophysiology of DD and its consequences. Ischemia, LV strain, Age, Arrhythmia, Systolic LV dysfunction, CPB (Cardio- Pulmonary Bypass) ... perioperative mortality and morbidity. Furthermore, DD is often associated with systolic dysfunction, left ventricular hypertrophy or indeed pulmonary hypertension. The mainstay of man...

Ngày tải lên: 10/08/2014, 10:20

... A, Ley K: Variation in the velocity, deformation, and adhesion energy density of leuko- cytes rolling within venules. Circ Res 1996, 79:1122-1130. Key messages • Leukocyte adhesion and microvascular ... produced by inflammatory mediators such as tumor necrosis factor and interleukin-1 [25], or by leukocyte adhesion, with effects on the underlying cytoskeletal structure or activation...

Ngày tải lên: 13/08/2014, 10:20

... Civil society and the state: Turkey after the earthquake. Disasters 2002, 26:120-39. 30. Liang NJ, Shih YT, Shih FY, Wu HM, Wang HJ, Shi SF, Liu MY, Wang BB: Disaster epidemiology and medical ... study conception and design, data collection, analysis, revision, editing and manuscript writing. HK was involved in the conception and design of study and took an active part in the data...

Ngày tải lên: 25/10/2012, 09:56

... descriptive analysis, which included the frequency and type of emergency. The frequency of aircraft diversion was also investigated. All data regarding names, ages and the sex of the patient and the ... 1968 and 1988, Air France reported 10 pilots were incapacitated by car- diac arrhythmias, seizures and hypoglycaemia during flight [8]. In one incident, carbon dioxide from improperl...

Ngày tải lên: 25/10/2012, 10:31