... control was maintained in a standard incubator with 21% O 2 . The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... overexpression, indicating that miR-27 does not play an important role in myogenic differentiation. Taken together, these results illustrate a critical and specific r...
Ngày tải lên: 18/02/2014, 08:20
... 945 The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation Heath Ecroyd and John A. Carver School of Chemistry and ... signifi- cantly increased the chaperone activity of aB-crystallin (84 ± 4%) against this target protein. The effect of Arg-HCl on the...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the structure of exchanging BS-RNase (1BSR) ... Nter are the C-terminal and N-terminal structural regions, respectively, of the two A and B monomers of the dimeric RNase. The black circle betw...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf
... substrate binding sites. In the case of the titin and twitchin kinases, the autoinhibitory sequence acts as a pseudo- substrate, occluding ATP binding and preventing protein substrates from binding ... CaM. However in PhK5 Trp357 is found at the C-terminal end of the peptide. This suggests that either PhK5 might bind with Trp357 in the N-terminal site in CaM, or...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... (2005) 16 2 516 38 ê 2005 FEBS 16 31 The role of N-glycosylation in the stability, trafficking and GABA- uptake of GABA- transporter 1 Terminal N-glycans facilitate efficient GABA- uptake activity of the GABA ... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1- Deoxymannojirimycin inhibits the GA...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf
... system. 4.1 Data The training set includes 349 clinical notes, with 11,967 assertions of medical problems. The test set includes 477 texts with 18,550 assertions. These assertions were distributed ... the training data to measure the impact of each of the four subsets of features explained in Section 3. Ta- ble 3 shows the cross validation results when cu- mulatively...
Ngày tải lên: 20/02/2014, 05:20
Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in Hierarchical Phrase-based Translation" pdf
... N N = 2048 N = 128 N = 64 N = 2048 331 Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1
Ngày tải lên: 20/02/2014, 07:20
Báo cáo khoa học: Biological role of bacterial inclusion bodies: a model for amyloid aggregation potx
... Journal compilation ª 2011 FEBS 2427 MINIREVIEW Biological role of bacterial inclusion bodies: a model for amyloid aggregation Elena Garcı ´ a- Fruito ´ s 1–3, *, Raimon Sabate 1,4, *, Natalia S. de ... Garcı ´ a- Fruito ´ s E, Gonzalez-Montalban N, Morell M, Vera A, Ferraz RM, Aris A, Ventura S & Villaverde A (2005) Aggregation as bacterial inclusion bo...
Ngày tải lên: 06/03/2014, 00:20
Báo cáo khoa học: Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70 Role of the divergent C-terminal a-helical subdomain pdf
... Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70 Role of the divergent C-terminal a-helical subdomain Fernando Moro 1 , Vanesa Ferna ´ ndez-Sa ´ iz 1 , ... that the interaction of mtHsp70 PBD with the DnaK ATPase domain modifies the accessibility of the substrate binding site. The thermal stability of the peptide comp...
Ngày tải lên: 16/03/2014, 22:20
báo cáo hóa học:" Emerging applications of fluorescence spectroscopy in medical microbiology field" potx
... (In press). BioMed Central Page 1 of 6 (page number not for citation purposes) Journal of Translational Medicine Open Access Review Emerging applications of fluorescence spectroscopy in medical ... detector, resulting in a Fluorescence trace (D). (Source: Shahzad A, Edetsberger M, Köhler G. Fluorescence Spectroscopy: An emerging excellent diagnostic tool in M...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo khoa học: "Ultrasonographic evaluation of tracheal collapse in dogs" potx
... degrees of tracheal collapse. The first tracheal ring can be easily defined and measured because the distal cricoid cartilage gives a landmark for the beginning of the first tracheal ring. However, ... accomplished within a few minutes. In addition, measurement of the TITRW/FTRW ratio can play a role in evaluating tracheal collapse. We think that ultrasonographic exam...
Ngày tải lên: 07/08/2014, 23:22
Báo cáo khoa học: " level applications of ecosystem classification for northwestern Canada" pptx
... article Stand and landscape level applications of a forest ecosystem classification for northwestern Ontario, Canada RA Sims 1 BG Mackey KA Baldwin 1 1 Canadian Forest Service, Ontario ... sustainable development. The Northwestern Ontario Forest Ecosystem Classification (NWO FEC) is an ecologically based forest site classification system for...
Ngày tải lên: 08/08/2014, 19:21
báo cáo khoa học: "Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs" doc
... citation purposes) Journal of Hematology & Oncology Open Access Review Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs Subhash Padhye 1,2 , ... between chalcone and garcinol moie-tiesFigure 2 A. Structural similarity between chalcone and garci- nol moieties. B. Formation of chalcone and mig...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "Emerging Applications of Bacterial Spores in Nanobiotechnology" potx
... amino acids) or CotB∆105 (275 amino acids) or CotC (66 amino acids) as carrier proteins (all in blue). The three 27-amino-acids repeats of full lenght CotB and the part of them remaining in ... t12) of storage at room temperature were examined by dot blotting of extracted spore coat proteins. Concentrations of purified TTFC (in nanograms) and of coat proteins (in microgra...
Ngày tải lên: 11/08/2014, 00:22
báo cáo khoa học: " Differential expression of cysteine desulfurases in soybean" potx
... an aminotransferase class-V motif and alignment analysis showed the location of a cysteineintheactivesiteandahistidineandalaninein the cofactor binding site (Additional files 1 and 2). To find ... proteins of the [Fe-S] cluster biosynthesis pathway, i.e. altering the expression of cysteine desulfurase genes. Stress dependent changes in gene expression occur in the cytoplasm a...
Ngày tải lên: 11/08/2014, 11:21