báo cáo khoa học: "Analysis of Gg-158(C®T) polymorphism in hemoglobin E/b-thalassemia major in Southern China" pps

... for ATP binding and hydrolysis and is believed to be involved in signal transduction, triggered by the presence of the pathogen [11-13]. The LRR domain is likely to be involved in protein-protein interactions, ... the following program: 96°C for 5 min; 35 cycles of 96°C for 1 min, 45°C for 1 min, and 72°C for 1 min; plus an extra elongation period of 10 min at 72°C. Cloning and sequ...

Ngày tải lên: 12/08/2014, 05:20

... rate of inbreeding when there is selection within families, but delays inbreeding for three or so generations in populations of this size and minimises the variation in inbreeding level within ... from a slight decline in the L lines. The estimate of linear regression of litter size at birth (assumed to be a trait of the dam) on the individual coefficient inbreeding in the C l...

Ngày tải lên: 09/08/2014, 18:21

... Access Analysis of G g-158(C®T) polymorphism in hemoglobin E/b-thalassemia major in Southern China Rong Rong Liu, Ming Yue Wang, Yong Rong Lai * Abstract Background: The G g-158(C®T) polymorphism ... HbE/b-thalassemia major and this polymorphism in Southern China. Methods and Results: The frequency of the G g-158(C®T) polymorphism has been evaluated in 32 patie...

Ngày tải lên: 10/08/2014, 22:21

... parti- cipates in v arious protein-protein interactions, playing a role in inhibiting apoptosis. In the endogenous apoptosis pathway, BCL2L1 of the BCL-2 family in hibits apoptosis by blocking the translocation ... other four genes of interest in the healthy controls. Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11...

Ngày tải lên: 10/08/2014, 22:21

... subheading and then select the Proteomics link). One of the proteins of interest to the Cell Migration Consortium is paxillin, a scaffolding protein involved in focal adhesions [9]. Shown in Fig. ... on the protein eluting under peak I [labeled in (A)] at a retention time of 30.8 min. (C) Sin- gle-scan, ETD ⁄ PTR tandem mass spectrum of protein [M + 11H] +11 ions at m ⁄ z 490.3...

Ngày tải lên: 18/02/2014, 16:20

... dynamics and kinetic properties of proteins in living cells [12–19]. FCS detects the fluctuations of fluorescent intensity derived from the movement of a single fluorescent molecule in a very tiny observation ... proper- ties of proteins [13] and binding interactions [14]. FRAP is a conventional technique used to study the kinetic properties of proteins in a cell by measuring the...

Ngày tải lên: 18/02/2014, 16:20

... was made in the case of cells expressing httEx1-72Q-EGFP (not shown). Hence, upregulation of ROS levels appears to be an intrinsic property of living COS-7 W. J. J. Firdaus et al. Huntingtin inclusions ... formation of carbonyl residues in proteins. The enhanced oxidation of pro- teins observed in httEx1-polyQ-expressing cells was not found to correlate with an increased intra...

Ngày tải lên: 19/02/2014, 06:20

... to discriminate against longer polypeptides. In A PP and CPA, the N-terminal ( APP) or the C-t erminal (CPA) end of the s ubstrate binds into a pocket and the absence of additional steric hindrance ... been inter- preted as zinc ions, and the positions of the two ions and the geometry of the amino-acids c oordinating them are s imilar in the three enz ymes. The weak d ensity of...

Ngày tải lên: 21/02/2014, 03:20

... structure fol- lowing it 3) The conj~tion is inserted in the node the first I~ that is found going up in the hierarchy (in fig.2.c, starting from C~NN2 and going u~s, we find 1:m.'.1 ... 1983)) this book-keeping need not be completely explicit, but the interpreter of the language (usually a dialect of PROLOG) has to keep track of the binding of the variables, of...

Ngày tải lên: 21/02/2014, 20:20

... defects in DNA binding (Fig. 5A), although their DNA-binding activities were not completely lost. We also examined the DNA-binding activity of Mhr1 in the absence of Mg 2+ , because the DNA- binding ... aromatic- rich loop in the first RecA-like domain of RecQ is important for the linking of ATP hydrolysis to DNA binding ⁄ unwinding [40]. Amino acid substitutions in the aromati...

Ngày tải lên: 06/03/2014, 09:22