báo cáo khoa học: "New targets for the treatment of follicular lymphoma" potx

... of the biological factors underlying the develop- ment of FL. The identification of new targets and development of novel targeted therapies is imperative to exploit the biological indolence of ... immunomodulators. These therapies could help to extend the duration of remission without adding any further burden of toxicity. It is also becoming clear that the therapy...

Ngày tải lên: 10/08/2014, 22:20

... for the optimal activity of BsArb43B. Furthermore, to determine whether the role of the calcium is structural, thermal shift assays were per- formed to determine the T m of the protein in the ... located (Fig. 4C). Removal of the histidine residue has the effect of relaxing the geometry of the cluster, resulting in a more planar arrangement of the Ca 2+ i...

Ngày tải lên: 15/03/2014, 23:20

... for all the associated information. VISULEX offers two levels of detail. At the first level, the information is presented by using only the comments associated with the codes found. At the ... hindered by two factors : the dispersal of infor- mation and the obscurity of the coding. In ARIANE-78, the lexical data base may reside on much more 50 files, for...

Ngày tải lên: 17/03/2014, 19:21

... orientation of the side chain of Glu221. The second conformation of the side chain of Glu221, which also adopts two conformations but not correlated with the anomeric form of the bound mannose is shown ... in the monosaccharide binding site [34]. The conformation of the GlcNAcb(1–2)Man entity occupying the )1 and M subsites of LOL roughly resembles the confor...

Ngày tải lên: 23/03/2014, 11:20

... germ lines. For clone 3F, VH3-VK3 were the closest families for V H and V L domains, respectively. In the case of C1, VH3- Vk1 were the families with highest scores. The specifici- ty of these two ... assays. The amounts of antibody used to neutralize 1 or 2 LD 50 of the toxin were 8.7 or 17.4 lg, which corresponded to a molar ratio of 1 : 10 in terms of Cn2 concent...

Ngày tải lên: 23/03/2014, 13:20

... analysis of one FS with the synthesis of another; they may be thought of as a specialized variety of pattern- matching rule. They are local in nature, and permit the recursive analysis and synthesis ... trate the use of the formalism in the areas of machine translation and reduction of FSs to canonical form. We conclude with an over- view of continuing strand...

Ngày tải lên: 01/04/2014, 00:20

... has been the focus of attention in immunotherapy and immunodiagnosis, since the birds can actively transfer immunoglobulin G (IgG) to the egg yolks of their offsprings in the same levels of concentration ... dangerous regaining of pathogenicity of mammalian pathogens in birds as the unusal host (3, 12, 16, 31, 32). The efficacy of IgY has been proven in several applica...

Ngày tải lên: 07/08/2014, 15:20

... of the limiting factors for the micro- propagation of recalcitrant mature trees is the loss of morphogenetic capacity of explants as the tree ages. In vitro cloning of mature ... of cultures. Pulse treatment has also been shown as an alternative treat- ment to the incorporation of the cytokinin into the medium for the induction...

Ngày tải lên: 08/08/2014, 18:21

... on the other hand, is homozygous for the « high » allele (A l ). All of the progeny from the standard cross have inherited the Al allele from the father and are, therefore, ... of interest, the genetic makeup of isofemale strains will differ as a function of the gene frequencies in the population and the probabilities of each...

Ngày tải lên: 09/08/2014, 22:22

... using CE (data not shown). Another drawback for the use of EDCHCl/sulfo-NHS for the formation of stable bioconjugates is the lack of specif- icity on the protein of interest. As numerous amine ... region close to the antigen-binding site (the hypervariable region). Either one of these variations can significantly reduce the efficiency of immunoassay applications [...

Ngày tải lên: 11/08/2014, 00:22