báo cáo khoa học: "New dosing schedules of dasatinib for CML and adverse event management" docx

... Oncology Open Access Review New dosing schedules of dasatinib for CML and adverse event management Siu-Fun Wong Address: Western University of Health Sciences, College of Pharmacy, Pomona, CA, USA Email: ... the optimal dosing regimen of dasatinib in CML and Ph+ ALL. In the CA180-034 study [44,52], patients with CP CML who were resistant to or intolerant of...

Ngày tải lên: 10/08/2014, 22:20

... 4.88 and 368 s for ours) and 7∼12 times faster for decod- ing (2.881 ms for MALLET, 5.028 ms for CRF++, and 0.418 ms for ours). This result demonstrates that learn- ing and decoding CRFs for large-scale ... those of Dense and Sparse. However, some results of Method 1, 3, and 4 were significantly inferior to those of Dense and Sparse for one of two reasons: 1...

Ngày tải lên: 23/03/2014, 17:20

... selection of natural questions. The articles varied in topic, degree of formality and the amount of details; from ”Horror film” and ”Christ- mas worldwide” to ”G-Man (Half-Life)” and ”His- tory of London”. ... the answers and offer bonuses for peo- ple providing good ones. However, both sites suffer from excess of information. FAQ-pages tend to also answer questions which a...

Ngày tải lên: 20/02/2014, 09:20

... 2.52 nmol P i ÆminÆmg )1 and an offset of 0.1 nmol P i ÆminÆmg )1 for SUR2A, and a K m of 41 lM,aV max of 0.73nmol P i ÆminÆmg )1 and an offset of 0.05 nmol P i ÆminÆmg )1 for SUR2B. A [ADP] (mM) 0.01 ... resembling that of NBD2 of SUR2A rather than that of NBD2 of SUR2B: this might indicate that these amino acids are responsi- ble for the lower ATPase activity o...

Ngày tải lên: 06/03/2014, 11:20

... only evaluated for three hand-picked classes, with preci- sion scores of 90% for names of countries, 87% for fish species and 68% for instances of constellations. Our evaluation of the accuracy of class ... clusters of queries based on vectors {V} 04. For each cluster of phrases S in {S} 05. {C S } = ∅ 06. For each query Q of S 07. Insert labels of Q from {M E }...

Ngày tải lên: 08/03/2014, 01:20

... distribution of sur- rounding words of target terms. For example, the distribution of co-occurrence words of the terms, the distribution of predicates which have the terms as arguments, and the ... relative weight of terms or words. Because information theory is well known for- malism describing information, we adopt the mechanism to measure information quantity of t...

Ngày tải lên: 08/03/2014, 04:22

... a mechanism for binding and sliding of the substrate chain. Barley AMY1 and AMY2 have a degree of multiple attack toward amylose of two (B. Kramhøft and B. Svensson, unpublished data). The goal of the ... time intervals (1, 3 and 5 min) by adding 500 lL of chilled 0.38 M sodium carbonate containing 1.8 m M cupric sulfate and 0.2 M glycine (500 lL)andkeptonice[36].Therate...

Ngày tải lên: 08/03/2014, 08:20

... concerns of the planner, and are expressed in its choices of information units and their description (cf. Mann and Moore [1983] for a discussion of similar concerns). 6. Status and Future ... Computational Theory of Prose Style for Natural Language Generation David D. McDonald and James D. Pnstejovsky Department of Computer and Information Science University...

Ngày tải lên: 09/03/2014, 01:20

... with minor conforma- tional differences between the pantetheine moieties of CoA and SPP. The highly similar mode of binding of the reactive moieties of CoA and SPP in the active site of thiolase ... acid A solution of 20 mmol d(+)-calcium pantothenate in 5 mL of 4 m HCl was extracted once with 40 mL of chloro- form ⁄ methanol (2 : 1) and three times with 40 mL of chlo-...

Ngày tải lên: 16/03/2014, 04:20

... conformation change of elongin C induced by binding of elongin B may occur and that this confor- mational change of elongin C leads to stabilization of elongin C and pVHL. To visualize the conformational change ... clarified that conformation of pVHL and ⁄ or elongin C in the absence of elongin B was different from that in the VBC complex and that conformation of elongin...

Ngày tải lên: 16/03/2014, 05:20