báo cáo khoa học: "P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia" pps

... of point mutations within the ABL kinase domain of BCR- ABL. Such mutations inhibit the ability of imatinib to bind to BCR-ABL by corrupting the binding sites or pre- venting the kinase domain ... Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and ki...

Ngày tải lên: 10/08/2014, 22:20

... marker information on paternal marker allele transmission were included in the analysis. Inclusion of offspring with incom- plete marker information in QTL mapping results in ... progeny. Progenies with incomplete marker information must be included in the statistical analysis to increase the statistical power and reduce bias and standard err...

Ngày tải lên: 09/08/2014, 18:21

... activators. It contains at least three distinct structural domains [43]: a fork-head domain at the C-terminus (a sequence of 80–100 amino acids forming a motif that is critical for DNA binding and nuclear ... is shared by all FOX proteins, a leucine zipper domain and a C2H2 zinc finger domain, both of which are thought to help mediate DNA binding and may be involved in the induction...

Ngày tải lên: 16/02/2014, 09:20

... using the protein standard depicted in Fig. 1. Smoothing spline curves through original and normalized data are shown as solid lines. M. Schilling et al. Strategies for standardizing quantitative ... pMOWS, containing HA-EpoR cDNA, was introduced into BaF3 cells by retro- viral transduction. Cell lines stably expressing HA-EpoR (BaF3-HA-EpoR) were selected and maintained in RPMI 164...

Ngày tải lên: 19/02/2014, 07:20

... mitochondria [15,30,31], and ornithine is exported to the cytosol to be converted into citrulline and arginine [31,32]. In plants, information on the localization of citrulline and arginine biosynthetic enzymes ... N-acetylornithine transaminase; GAT, glutamate N-acetyltransferase; AOD, N-acetyl- ornithine deacetylase; OCT, ornithine carbamoyltransferase; ASS, argininosuccinate syntha...

Ngày tải lên: 20/02/2014, 03:20

... In CoNLL-2005. Y. Chen, M. Zhou, and S. Wang. 2006. Reranking answers from definitional QA using language models. In ACL’06. M. Collins and N. Duffy. 2002. New ranking algorithms for parsing and ... SVMs and the above models suggest that syntactic information helps tasks such as question classification whereas semantic informa- tion contained in PAS and PASN gives promising re...

Ngày tải lên: 20/02/2014, 12:20

... 2009. c 2009 Association for Computational Linguistics Analysing Wikipedia and Gold-Standard Corpora for NER Training Joel Nothman and Tara Murphy and James R. Curran School of Information Technologies University ... explore intra- and inter-corpus consistency in MUC, CoNLL, and BBN in Section 4. 3.1 N-gram tag variation Dickinson and Meurers (2003) present a clever metho...

Ngày tải lên: 22/02/2014, 02:20

... bridge and New York. Weinberg, Amy, Joseph Garman. Jeffery Martin. and Paola Merlo. 1995. Principle-Based Parser for Foreign Language Training in German and Arabic. In Melissa Holland, Jonathan ... selection and the interpretation of events in machine transla- tion and foreign language tutoring applications, re- spectively. 2 Lexical Aspect Following Olsen (To appear...

Ngày tải lên: 22/02/2014, 03:20

... as described in Shen et al. [11]. Briefly, OAT activity measured using endogenous substrates was performed by incubating 50 lg of protein in 30 lLof50m M potassium phosphate buffer, pH 7.0, containing ... avoided purification and cloning, remaining elusive despite the efforts of a number of groups. Nevertheless, the information reported here adds consider- ably to our understanding of si...

Ngày tải lên: 07/03/2014, 14:20

... stage fills in these missing links. Minimization 2 (MIN2). This stage uses the original minimization formulation for the su- pertagging problem IP original , again using an in- teger programming method ... 3 and 4, summarized below: EM HMM uniformly initialized, EM training. EM+IP IP minimization using initial grammar provided by EM. EM GI HMM with grammar-informed initializa- tion, EM...

Ngày tải lên: 07/03/2014, 22:20