Báo cáo y học: "High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma" doc
Báo cáo y học: "High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma" doc
... level in DLBCL (A)negative nuclear staining of STAT3, (B) negative nuclear staining of P -STAT3, (C) weak nuclear staining of STAT3, (D)weak nuclear staining of P -STAT3, (E) strong nuclear staining of ... ZL et al.: High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma.Journal of Hematology & Oncology 2011 4:31.Submit your next manuscript ... zj@bjcancer.org1Department of Lymphoma, Peking University School of Oncology, BeijingCancer Hospital & Institute; Key Laboratory of Carcinogenesis andTranslational Research (Ministry of Education); Beijing 100142,...
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Báo cáo y học: "Relaxin''''s induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint" ppsx
... stromelysin-1.Figure 3Induction of matrix metalloproteinases by relaxin but not by estrogen is accompanied by loss of glycosaminoglycans (GAGs)Induction of matrix metalloproteinases by relaxin ... joint fibrocartilaginous tissues or itsinduction of MMPs has not been linked to the loss of matrixmacromolecules in any tissue. In this study we determined the effects of relaxin with orwithout ... amount of collagen in fibrocartilaginous tissues from different sites, including thepubic symphysis and synovial joints. These findings alsosuggest that in fibrocartilaginous tissues, including...
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Báo cáo y học: " High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life" pdf
... community-based recruit-ment of asymptomatic women, the relatively large number of study participants, and measurement of CRP by a highly sen-sitive assay. A potential limitation of this study is ... This should be further assessed by alongitudinal study.IntroductionOsteoarthritis (OA) is a major cause of morbidity, affecting60% of men and 70% of women over the age of 65 years [1]. In ... T, Shindo H: Interleukin-6 levels in syn-ovial fluids of patients with rheumatoid arthritis correlated with the infiltration of inflammatory cells in synovialmembrane. Rheumatol Int 2006, 26:1096-1100.25....
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Báo cáo y học: "The ITGAV rs3738919-C allele is associated with rheumatoid arthritis in the European Caucasian population: a family-based study" docx
... torefine the associated haplotype. In the same way, the chromosome 2 linkage suggestionobserved in the genome scan of our laboratory could not betotally explained by the findings of the ITGAV linkage; ... clinically indicated. Instead, the clinical relevance of the finding is likely to come through better understanding of the RA pathophysiology and may lead to new therapeutictargets.Contrary ... encoded by the ITGAVgene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility...
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Báo cáo y học: "High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis
... regulators of cell apoptosis, it is possible that HBV infection might alter the cIAPs gene expressing of liver cell, finally instigating the carcinogenesis of the cells it infected. This is agreement ... bbiiooggrraapphh y y Xuanyong Lu, PhD is an Assistant Professor of Drexel Institute for Biotechnology and Virology Research, School of Medicine, Drexel University, USA. His current researches investigate ... entry of hepatitis B virus, pathology of HBV infection and hepatocellular carcinoma (HCC). Previously he was an assistant professor in Department of Biochemistry and Molecular Pharmacology,...
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Báo cáo y học: "High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis" ppsx
... perivasculary and always in the synovial lining andsub-lining layers of the synovium. FcγRII and III positive cellswere also observed within lymphocyte infiltrates. The IgG1 iso-type control antibody ... toclearly distinguish between FcγRIIa and IIb, as was demon-strated in our stainings of cell lines (Figure 1b). The staining of healthy synovia (Figure 3a) revealed a novel finding in thatFcγRI expression ... biopsies. FcγRIIb staining was observed in the synovial lin-ing and sub-lining layers, perivasculary and inside lymphocyte infiltrates (e). (d) No staining of the RA synovium was observed when...
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Báo cáo y học: "The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden" pdf
... recently been shown to act synergisti-cally as risk factors, but only in anti-CCP antibody-positivepatients with RA [17].Considering our findings of a stronger predictive value of thecombination ... that a missense single nucleotidepolymorphism resulting in a substitution of T for C at position1858 in the protein tyrosine phosphatase nonreceptor type 22(PTPN22) gene is associated with several ... counties of Sweden with early RA (duration of symptoms < 12 months) were consecu-tively included in the study and followed for 2 years. A total of 563 individuals fulfilling at least four of the...
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Báo cáo y học: "High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis" potx
... lanescorrespond to individual patients within Table 1. Staining of theindicated proteins on parallel blots is shown. Equal loading of tissueextracts was controlled by β-actin protein staining. MW indicates ... development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).Arthritis Res 2001, 3:65-71.34. Baggiolini M, Dewald ... measurement.ImmunohistochemistryFor immunohistologic analysis of distribution of CXCR1,CXCR2, and CXCR3, synovial tissue from patients with RA and OA was fixed in 4% formaldehyde immediatelyafter surgery and...
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Báo cáo Y học: Cloning and expression of sterol D14-reductase from bovine liver potx
... regulatory mechanisms of the D14-SR gene expression and its possible role in the metabolism of meiosis activating sterols. Mutation analysis of TM7SF2will clarify whether a defect in this gene underlies ... localization of theenzymes involved in cholesterol biosynthesis and with thepuri®cation of the bovine protein from the ER.Determination of D14-SR activity. To demonstrate thatthe cloned bovine liver ... pathway of cholesterolbiosynthesis.Recently t he human lamin B receptor (LBR), an integralprotein of the inner nuclear membrane, has been shown t oexhibit D14-SR activity [17]. Two protein p...
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Báo cáo Y học: Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leaves potx
... the physiologicalrole of these proteins in D. purpurea. Work is underway todetermine the precise role of DpARs in plant steroidmetabolism in general and in cardenolide biosynthesis in particular. ... by a family of atmost five genes.A characteristic function of the ARs is the catalysis of thefirst reaction in the polyol pathway, the reduction of glucoseto sorbitol. In mammals they play ... transformed with pQAR1 or pQAR2, using a His-binding resin column.The purified proteins were visualized as a single band of 35 kDa after SDS/PAGE. To test the cofactor specificity of the recombinant...
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