VASCULAR COMPLICATIONS OF DIABETES - PART 10 potx

... 23 PKC-β 2 5.9 19 PKC-γ 300 110 PKC-δ 250 28 PKC-ε 600 18 PKC-ζ > ;10 5 >1.5 × 10 3 PKC-η 52 5 Cyclic AMP kinase > ;10 5 100 Ca 2+ -calmodulin kinase 8 × 10 3 4 Casein kinase > ;10 5 1.4 × 10 4 Src ... (DCCT) 113 diabetic foot 105 10 amputation 105 , 106 , 107 , 125 angioplasty 107 callus formation 105 causes 105 –6, 105 education 107 healing 107 , 108 h...

Ngày tải lên: 10/08/2014, 18:21

... with diabetes. Much of our infor- mation on interventions that prevent or retard the vascular complications of diabetes are derived from either sub-group analyses of larger trials, or extrap- olation ... β2-ADR, β2-adrenergic receptor; EP-R, prostaglandin E receptor; VIP-R, vasoactive intestinal peptide receptor; NO, nitric oxide. NO VIP Nitrergic Smooth muscle Vipergic VIP-R K...

Ngày tải lên: 10/08/2014, 18:21

... bibliographical references and index. ISBN-13: 97 8-1 -4 05 1-2 78 5-1 (alk. paper) ISBN -1 0: 1-4 05 1-2 78 5-6 (alk. paper) 1. Diabetic angiopathies. [DNLM: 1. Diabetes Complications. 2. Diabetic Retinopathy ... 4. Vascular Diseases etiology. WK 835 V3305 2005] I. Donnelly, Richard, 196 0- II. Horton, Edward S. RC700.D5V375 2005 616.1'3 dc22 2005008488 ISBN-13: 97...

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... cohort study found a history of MI in 16.5% of males and 9.7% of females at the time of diagnosis of diabetes. During a 1 0- year follow-up the age-adjusted inci- dence of first MI was 1.5-fold higher in diabetic ... per 100 000 per year (log scale) 10 000 100 0 100 10 1 0 10 14 15–19 20–24 25–29 35–39 30–34 40–44 45–49 55–59 65–69 50–54 60–64 Age (years) SECTION I • M...

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... 258–268. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes ... 15 SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES 74 Retinopathy The DCCT demonstrated beyond doubt that good glycaemic control retard- ed the on...

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... In the Diabetes Control and Complications Trial (DCCT) ‘clinically detectable’ neu- ropathy was found in 39% of the participants who had type 1 diabetes. In the Epidemiology of Diabetes Complications ... VEGF expres- sion in controls. Intramuscular gene transfer of plasmid DNA encoding VEGF- 1 or VEGF-2 in the STZ-diabetic rat and alloxan diabetic rabbit results in restora- tio...

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... with diabetes over the age of 30 is partly due to the difficulty in determining the precise date of onset of disease. The prevalence of retinopathy at the time of diag- nosis of type 2 diabetes ... the development of dia- betic retinopathy. The US Diabetes Control and Complications Trial (DCCT) evaluated the rates of development of microvascular complications in tw...

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... Publishing Ltd Fig. 17.2 Frequency of macular oedema by duration of diabetes for insulin- and non-insulin-taking older onset persons. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. IV. ... diagnosis of ischaemia may be difficult in the pres- ence of significant leakage since this obscures the view of the retinal micro- circulation on fluorescein angiograms. Complic...

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... of proteins Polyol pathway Fructose- 3- phosphate Via fragmentation of triose phosphate Glyoxal MGO 3-DG CML GOLD CEL MOLD Advanced glycated end-products In vivo sources of α-oxoaldehydes α-oxoaldehydes α-oxoaldehydes Via catabolism of ... as 3- deoxyglucosone (3-DG) and methylglyoxal (MGO). 3-DG is formed by non- oxidative rearrangement and hydrolysis of Amadori adducts and f...

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... (% of control) 150 140 130 120 110 100 0 0 100 110 120 130 140 150 160 170 0 010 -1 1 10 -1 0 10 -9 TPA (M) 10 -8 10 -7 10 -6 n.s 10 20 Glucose (mM) Mannose 30 40 520 mmol Table 21.1 Diabetes- related ... - Retina Rat, canine ↑↑ - II, δ Aorta Rat, canine ↑↑ - Glomeruli Rat, mouse ↑↑ - , - I, - Monocytes Human NM ↑ - II ↑ = inc...

Ngày tải lên: 10/08/2014, 18:21