VASCULAR COMPLICATIONS OF DIABETES - PART 5 ppsx

... In the Diabetes Control and Complications Trial (DCCT) ‘clinically detectable’ neu- ropathy was found in 39% of the participants who had type 1 diabetes. In the Epidemiology of Diabetes Complications ... VEGF expres- sion in controls. Intramuscular gene transfer of plasmid DNA encoding VEGF- 1 or VEGF-2 in the STZ-diabetic rat and alloxan diabetic rabbit results in restora- tio...

Ngày tải lên: 10/08/2014, 18:21

... 4. Vascular Diseases etiology. WK 8 35 V33 05 20 05] I. Donnelly, Richard, 196 0- II. Horton, Edward S. RC700.D5V3 75 20 05 616.1'3 dc22 20 050 08488 ISBN-13: 97 8-1 -4 05 1-2 78 5- 1 ISBN-10: 1-4 05 1-2 78 5- 6 A ... bibliographical references and index. ISBN-13: 97 8-1 -4 05 1-2 78 5- 1 (alk. paper) ISBN-10: 1-4 05 1-2 78 5- 6 (alk. paper) 1. Diabe...

Ngày tải lên: 10/08/2014, 18:21

... scale) 10000 1000 100 10 1 0 10–14 15 19 20–24 25 29 35 39 30–34 40–44 45 49 55 59 65 69 50 54 60–64 Age (years) SECTION I • MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES 22 CONCLUSION Risk factors for the micro- and ... cohort study found a history of MI in 16 .5% of males and 9.7% of females at the time of diagnosis of diabetes. During a 10-year follow-up the...

Ngày tải lên: 10/08/2014, 18:21

... Lancet 2000; 355 : 253 – 259 . Cumulative mortality Kaplan-Meier rates 0.08 0.10 0.12 0.06 0.02 0.04 0.00 0 50 0 Days of follow-up Ramipril Placebo RRR = 37% (2 1 -5 1) P=0.0001 1000 150 0 2000 CHAPTER ... end-point No. of patients 5 Absolute risk reduction 5% Relative risk 11% Increase in patients without end-point No. of patients 5 Absolute increase 5% Relative increase 9...

Ngày tải lên: 10/08/2014, 18:21

... infarction Stroke Cardiovascular death 0.12 Kaplan-M 0 08 0.04 0 0 50 0 1000 2000 150 0 0.08 0.06 Kaplan-M 0 04 0.02 0 0 50 0 1000 2000 150 0 0.12 0.09 Kaplan-M 0 06 0.03 0 0 50 0 1000 Duration of follow-up (days) 2000 150 0 CHAPTER ... history is for 65 CHAPTER 7 • EVIDENCE-BASED INTERVENTIONS Fig. 7.1 Effects of ramipril on cardiovascular outcomes in people with diabetes – MICRO-...

Ngày tải lên: 10/08/2014, 18:21

... with diabetes over the age of 30 is partly due to the difficulty in determining the precise date of onset of disease. The prevalence of retinopathy at the time of diag- nosis of type 2 diabetes ... 2.67) 2.80 (1.66, 5. 05) 2.67 (1.48, 5. 08) 1.87 (1. 35, 2.84) CHAPTER 15 • EPIDEMIOLOGY AND RISK FACTORS 131 Fig. 15. 1 Frequency of any retinopathy and prolifereative retino...

Ngày tải lên: 10/08/2014, 18:21

... 43% of those examined with proliferative dis- ease had type 1 diabetes whilst 42% had insulin-treated type 2 diabetes. The severity of proliferative disease is generally greater in type 1 diabetes, ... average of approximately 0 .5 0.6 mm. In Vascular Complications of Diabetes: Current Issues in Pathogenesis and Treatment, Second Edition Edited by Richard Donnelly, Edward Ho...

Ngày tải lên: 10/08/2014, 18:21

... HYPERGLYCAEMIA INDUCED VASCULAR DYSFUNCTION 180 Age-adjusted death rates: all-cause, CVD, IHD & non-cardiovascular Glycated haemoglobin (%) Self- χ 2 reported (linear < 5 5 5. 4 5. 5- 6 .9 ≥ 7 diabetes ... of proteins Polyol pathway Fructose- 3- phosphate Via fragmentation of triose phosphate Glyoxal MGO 3-DG CML GOLD CEL MOLD Advanced glycated end-products In vivo sour...

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... (% of control) 150 140 130 120 110 100 0 0 100 110 120 130 140 150 160 170 0 010 -1 1 10 -1 0 10 -9 TPA (M) 10 -8 10 -7 10 -6 n.s 10 20 Glucose (mM) Mannose 30 40 52 0 mmol Table 21.1 Diabetes- related ... - Retina Rat, canine ↑↑ - II, δ Aorta Rat, canine ↑↑ - Glomeruli Rat, mouse ↑↑ - , - I, - Monocytes Human NM ↑ - II ↑ = increased; NM =...

Ngày tải lên: 10/08/2014, 18:21

... 158 cystoid 157 , 172 duration of diabetes 152 , 153 and retinopathy 152 maculopathy 139, 141, 151 –61 diagnosis 153 –6 diffuse oedema 157 epidemiology 151 fluorescein angiography 153 , 154 5, 155 , ... 23 PKC-β 2 5. 9 19 PKC-γ 300 110 PKC-δ 250 28 PKC-ε 600 18 PKC-ζ >10 5 >1 .5 × 10 3 PKC-η 52 5 Cyclic AMP kinase >10 5 100 Ca 2+ -calmodulin kinase 8 × 10 3 4 Casein...

Ngày tải lên: 10/08/2014, 18:21