Hematologic Malignancies: Myeloproliferative Disorders - part 6 pdf

... Aurora-A and -B are frequently overexpressed in human cancer leading to aneuploidy and cancer devel- opment. The Aurora-kinase inhibitor VX -6 8 0 (recently renamed MK-0457) inhibits Aurora-A, -B, -C, ... LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating muta- tion of FLT-3. Mol Pharmacol, 67 :1 166 –11 76 Ravandi-Kashani F, Ridg...

Ngày tải lên: 10/08/2014, 16:22

... USA London W12 0NN UK ISBN-10 3-5 4 0-3 450 5-1 Springer Berlin Heidelberg New York ISBN-13 97 8-3 -5 4 0-3 450 5-3 Springer Berlin Heidelberg New York Library of Congress Control Number: 20 069 264 28 A catalog record ... Quarter of the 20th Century 9 Eckhardt S, Sellei C, Horvath IP, Institorisz L (1 963 ) Effect of 1 , 6- dibro- mo-1 , 6- dideoxy-D-mannitol on chronic granuloc...

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... 68 .3 72.1 72 .6 Hepatomegaly (%) 47.9 53.2 46. 3 Spleen size (cm below costal margin) 6. 2 6. 4 6. 4 6. 7 6. 5± 6. 5 Liver size (cm in mid clavicular line) 12.7±2.3 12.8±2 .6 12 .6 2.7 IFN =Interferon-a; ... (2005) Wide- spread occurrence of the JAK2 V617F mutation in chronic myelo- proliferative disorders. Blood 1 06: 2 162 –2 168 Kain K, Klemke R (2001) Inhibition of cell migratio...

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... RI Score 0 65 2 60 72 20 26 1 569 18 60 70 23 23 2 881 28 47 62 31 32 3 867 28 37 48 46 31 4 485 15 35 40 51 28 5 214719187141 6 57 2 16 22 73 32 7 4––––– 5-year probability of leukemia-free survival ... constitutively acti- vated by Bcr-Abl in CML cells. Two of its known sub- strates, ribosomal protein S6 and 4E-BP1, are constitu- tively phosphorylated in a Bcr-Abl-dependent manner...

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... J, Borzilleri RM (2004) Discovery of N-(2-chloro -6 - methyl- phenyl )- 2-( 6- ( 4-( 2-hydroxyethyl)-piperazin-1-yl )-2 -methylpyrimidin-4 yla- mino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor ... Blood 1 06: 52a, abstract 166 Srivastava PK (2000) Immunotherapy of human cancer: lessons from mice. Nat Immunol 1: 363 – 366 Srivastava PK (2002) Roles of heat-...

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... Manifestations 261 15.5 Laboratory Features 264 15 .6 Prognosis 264 15.7 Management 266 15.7.1 Medical Therapy 266 15.7.1.1 Cytotoxic Therapy 266 15.7.1.2 Androgens 266 15.7.1.3 Erythropoietin 266 15.7.1.4 ... Interferon 266 15.7.1.5 Thalidomide 267 15.7.1 .6 Experimental Therapy . . 267 15.7.2 Surgery and Radiotherapy 267 15.7.2.1 Splenectomy 267 15.7.2.2 Radiotherapy 268 15....

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... (50%) of 16 pa- tients with idiopathic myelofibrosis had a G-to-T trans- version in exon 12 of the JAK2 gene, (V617F) in the neg- ative regulator y JH2 domain (Baxter et al. 2005). Kralo- vics et ... Polycythemic Disorders – Biological Aspects Table 17.2. Human hematologic malignancies with dys- regulated protein kinases Malignancy Protein kinase ALCL ALK-1 ALL BCR-ABL FLT3 TEL-ABL TEL-J...

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... 291 splenomegaly 60 , 223, 261 , 263 , 266 , 281, 283, 284, 2 86, 291 Src-related kinase 166 staging systems 63 STAT 51, 308, 324 – activation 25 – pathway 24 STAT3 protein 305 STAT5 2 56 – pathway 39 stem ... 44 SGX-70430 211 Sheffield schema 264 SHP-1 301, 325 side population 203 Sirolimus 94 small interfering RNA (siRNA) 1 76 SOCS 325 Sokal score 64 , 1 16, 213 sorafenib 175 splene...

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... normal Chapter 007. Medical Disorders during Pregnancy (Part 6) Thyroid Disease (See also Chap. 335) In pregnancy, the estrogen-induced increase in thyroxine-binding globulin causes an ... then adjust the dose by serial measurement of TSH. Hematologic Disorders Pregnancy has been described as a state of physiologic anemia. Part of the reduction in hemoglobin concentration...

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... pathway involving the NF-κB superfamily. Among these eleven NF-κB-regulated genes are apopto- sis inhibitor-2, tumor necrosis factor-α-induced protein 2, MAX protein, IL -6 , nuclear factor of kappa ... acute lym- phoblastic leukemia (ALL). Blood 2005; 1 06: 4303–7. 36. Gleissner B, Goekbuget N, Rieder H, et al. CD-10-nega- tive pre-B acute lymphoblastic leukemia (ALL): a dis- tinct high-r...

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