Statistical Methods in Medical Research - part 10 docx

Statistical Methods in Medical Research - part 10 docx

Statistical Methods in Medical Research - part 10 docx

... J. Endocrinol. 31, 95 105 . Concorde Coordinating Committee (1994) Con- corde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Lancet ... Sherwin R. (1981) Screening and diagnosis when within- individual observations are Markov-depen- dent. Biometrics 37, 553±565. Wilson P.W. and Kullman E.D. (1931) A statis- tical inquir...

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Statistical Methods in Medical Research - part 8 docx

Statistical Methods in Medical Research - part 8 docx

... data obtained. It was originally developed in pioneering work by A. Wald (1902±50). Implicit in any sequential analysis is the concept of a stopping rule, defining the way in which the termination ... schemes with five interim inspections, as detailed in Table 18.4. (ÐÐ) Pocock; (± ± ±) O'Brien±Fleming; (- - -) Haybittle±Peto. if the alternative hypothesis is true (in th...

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Statistical Methods in Medical Research - part 1 pptx

Statistical Methods in Medical Research - part 1 pptx

... corresponding to 101 may have been 101 Á42, in which case the result of the addition now should have been 105 Á81, or 106 to the nearest integer. These considerations are particularly important in sub- traction. ... formulae and, more particularly, the concepts behind them. Even the more advanced methods described in this edition are being extensively used in medical research...

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Statistical Methods in Medical Research - part 2 ppt

Statistical Methods in Medical Research - part 2 ppt

... 4.3 Gain in weight (g) between 28th and 84th days of age of rats receiving diets with high and low protein content. High protein Low protein 134 70 146 118 104 101 119 85 124 107 161 132 107 94 83 113 129 97 123 Total ... that in many statistical investigations there is no formal process of sampling from a well-defined population. For instance, the prevalence of a certain disease...

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Statistical Methods in Medical Research - part 3 ppsx

Statistical Methods in Medical Research - part 3 ppsx

... suitable choice of para- meters for a non-informative prior is a  1 2 , b I, which has an infinitely 178 Bayesian methods Example 6.2 In the clinical trial described in Example 4.6, 100 patients receive ... made absolute in the United Kingdom during the first half of this century and the amount of tobacco imported (the `individuals' in the scatter diagram here being the indi...

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Statistical Methods in Medical Research - part 4 pps

Statistical Methods in Medical Research - part 4 pps

... in the following table, arranged in ascending order in both rows and columns. They give the following 55 1 2 Â 10 Â 11 pair means: 276 Analysing non-normal data Table 9.8 Notation for Latin ... the main effects or interactions, it will usually be convenient if we can arrange to lose information about the higher-order inter- actions rather than the main effects or lower-order intera...

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Statistical Methods in Medical Research - part 5 pptx

Statistical Methods in Medical Research - part 5 pptx

... an influential point, or both. In (a), the regression through nine points is shown. In each of (b) to (e) a 10th point has been added, indicated by Â, and the regression through the set of 10 ... through these nine points; this point does not influence the slope of the fitted regression. In Fig. 11 .10( c), there is an additional point that is distant from the other nine points and li...

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Statistical Methods in Medical Research - part 6 pps

Statistical Methods in Medical Research - part 6 pps

... methods can be found in Goldstein (1995, Chapter 4). 12.6 Longitudinal data In many medical studies there is interest not only in observing a variable at a given instant but in seeing how it changes ... Longitudinal data 447 can often help in circumstances where the analysis is intended to shed light on deeper aspects of the problem being studied. The linear methods, including...

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Statistical Methods in Medical Research - part 7 ppsx

Statistical Methods in Medical Research - part 7 ppsx

... two-factor inter- actions to be significant and it is prudent to try including each of the six two-factor interactions in turn to the model. As an example, when the interaction of the two kinds of ... One option of obtaining a two-sided exact level, which we advocated, is to double the one-sided level, giving 0Á0067 and 0Á 010 for the mid-P and P values, respectively. So, in this example...

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Statistical Methods in Medical Research - part 9 pptx

Statistical Methods in Medical Research - part 9 pptx

... only of their agreement in a particular situation. The problems discussed in the previous paragraph are analysed in detail by Cicchetti and Feinstein (1990) and Feinstein and Cicchetti (1990). ... of a discriminant function (p. 467); the discrimination is per- formed here by the single variable x. Instead of an all-or-none classification as healthy or diseased, it may some- times be use...

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