Liver Transplantation - part 3 pot

... after liver transplantation. Reasons for malnutritioninclude:• Anorexia (common)• Inappropriate dietary advice. In particular, patients with end-stage liver 30 Liver Transplantation 3 Acetaminophen ... www.eurotransplant.nl.Contraindications to Liver Transplantation Absolute and relative contraindications to liver transplantation are shown in Tables 3 and 4.26 Liver Transplantation 3 • Few multifocal hepatocellular ... capacity21Assessment for Liver Transplantation 3 Live Liver DonationThe use of live donors for liver transplantation was developed in response to theinadequate donor organ supply. Live liver donation...

... second-line drug60 Liver Transplantation 6 Liver Transplantation, edited by Michael R. Lucey, James Neuberger and Abraham Shaked.©20 03 Landes Bioscience.CHAPTER 6Immunosuppression after Liver Transplantation James ... interactionsAntibodies to ICAM-1Antibodies to IL2-RCTLA-4 IgTable 3. Immunosuppressive drugs: AzathioprineDrug name AzathioprineMechanism of action Anti-metabolite; metabolised to 6- mercaptopurine and ... Tcells; suppresses T-cell activation by inhibiting synthesisand release of IL-2 and other lymphokinesSide-effects Renal impairment (3 0-4 0%); hepatotoxicity (10%);hypertension (30 %); gum hypertrophy...

... Probable:-Retransplantation for chronic rejection-Late acute rejection episodes-Steroid-nonresponsive acute cellular rejectionControversial Associations:-Underlying liver disease-AICAH-PBC-PSC-Positive ... De-fining the outcome of immunosuppression withdrawal after liver transplantation. Hepatology 1998; 27:92 6-9 33 . 3. Jain A, Kashyap R, Marsh W, Rohal S, Khanna A, Fung JJ. Reasons for long-termuse ... profoundly immuno-suppressed-Histology:• Polyclonal B-cell lymphoproliferation-Treatment:• Acyclovir-Outcome:• Usually excellent response to acyclovirPolymorphic B-cell Lymphoma-Clinical Presentation:•...

... normalPositiveIrrespectiveof liver functiontestsKnodell score > 6NegativeAbnormal liver functiontest results Liver biopsyInterferon tribavirin Repeat liver functiontests every 3 monthsRepeat liver biopsy ... with deteriorating liver function with progressive secondary biliary cirrhosis.Summary pointsx Most drugs have potential to cause liver injury, and 2-7 % ofadmissions with non-obstructive jaundice ... offulminant liver failure in the United Kingdom and is anaccepted indication for liver transplantation. As this is an acute liver injury, patients who survive without the need fortransplantation...

... v.SPLEENSuperiormesenteric v.Renalv.KIDNEY LIVER IVCNormalanatomyEnd-to-sideporta-cavalanastomosisSide-to-sideporta-cavalanastomosisFig. 10. 53. The types of surgical portal-systemic shuntoperation performed ... J.Med. 1999; 34 1: 4 03. 74 Spahr L, Villeneuve J-P, Tran HK et al. Furosemide-inducednatriuresis as a test to identify cirrhotic patients with refrac-tory ascites. Hepatology 2001; 33 : 28.75 Strauss ... radicles with accompa-nying mild fibrosis and lymphocyte infiltration. Theincreased intra-hepatic resistance may persist after oblit-eration of the fistula.Fig. 10 .39 . A64-year-old man with polycythaemia...

... 442 3. 13 Comert B, Mas MR, Erdem H et al. Insulin resistance innon-alcoholic steatohepatitis. Dig Liver Dis 2001; 33 : 35 3–8.14 Marchesini G, Brizi M, Bianchi G et al. Non-alcoholicfatty liver ... peroxidation (e.g. 3- nitrotyrosine [ 3- NT]) are increased both in fatty liver as well asNASH [ 13] . However, the levels of 3- NT are higher inthose with NASH compared to those with fatty liver alone. ... accumulate in the liver atrelatively low levels of FFA flux through the liver. -1 25 -1 00 -7 5 -5 0 -2 5010 mU/m2/min 40 mU/m2/minNASH Fatty liver Insulin infusion rate% ChangeFig. 7 .3 The effects...