báo cáo khoa học: "Reduced expression of SMAD4 in gliomas correlates with progression and survival of patients" ppt

... staining of SMAD4 protein in tumor cells of GBM (A) and astroc ytoma (B) (Original magnification ×400). Staining for this antigen is described in Materials and Methods. Positive staining of SMAD4 ... findings of the immunohis- tochemistry analysis and indicated a close correlation of SMAD4 protein expression with WHO grade. 3.3 Quantitative analysis of SMAD4...

Ngày tải lên: 10/08/2014, 10:21

... gene were correlated with EGFR protein expression and clinical response in NSCLC patients treated with EGFR tyrosine kinase inhibitor[18]. To find markers that could predict gemcitabine sensitivity, ... HC and HY participated in the collection of samples and follow-up. All authors read and approved the final manuscript. Competing interests The authors declare that they hav...

Ngày tải lên: 10/08/2014, 22:20

... diagnosis of Poland syndrome in our patient. Further genetic and pathological studies of the involved blood vessels in patients with Poland syndrome could lead to a better understanding of the disease. Introduction Poland ... brain, cerebellum, and brain stem, with a predominance of lesions in the left hemisphere. Conclusion: The distribution of cavernous malformations...

Ngày tải lên: 10/08/2014, 23:20

... protective effect of cadaverine was s ignificant. For example, after 15 min of incu bation, the remaining activity was 15% in the reaction mixture with cadaverine and only 8% without. Due to the potential information ... against mechanism-based inhi- bitors by their substrates and competitive inhibitors. These compounds bind at the active site and compete with binding of the...

Ngày tải lên: 19/02/2014, 16:20

... reverse-joined hairpin ribozymes and engineering of twin ribozymes consisting of conventional and reverse-joined hairpin ribozyme units Sergei A. Ivanov, Ste ´ phanie Vaule ´ on and Sabine Mu ¨ ller Ruhr-Universita ¨ t ... hairpin ribozyme by dissecting the two domains at the hinge between helix 2 and helix 3 and rejoining helix 4 to helix 1 via a linker of six unpaired residu...

Ngày tải lên: 20/02/2014, 01:20

... Web. In proceedings of the 5th FinTAL, Finland. Eugenie Giesbrecht and Stefan Evert. 2009. Part -of- speech tagging - a solved task? An evaluation of PoS taggers for the Web as corpus. In proceedings ... convenient and more easy to understand. However when it comes to in- teresting and suprising facts users enjoyed exploring the results using the topic graph. The overall feel...

Ngày tải lên: 20/02/2014, 05:20

... training algorithm of Collins (2002) to learn a discriminative model map- ping from inputs x ∈ X to outputs y ∈ Y , where X is the set of sentences in the training corpus and Y is the set of ... then trained the outside-layer linear model using the outputs of these sub-models, including the perceptron. Since the per- ceptron is fixed during the second training step, the whole train...

Ngày tải lên: 08/03/2014, 01:20

... and Lee, 1996) is based on Eric Brill's tagging model (Brill, 1993). This tagging system is a hybrid system using both statistical training and rule-based training. Rule-based training ... Computing, pages 119-124. J. Shin, Y. Han, Y. Park, and K. Choi. 1995. "A HMM Part -of- Speech Tagger for Korean with wordphrasal Relations". In Proceedings of Recent Advan...

Ngày tải lên: 08/03/2014, 05:21

... escaping to the cytoplasm. In order to gain insight into the interaction of the stator arginine with the binding site, we modeled a stretch of seven amino acids of helix 4 of subunit a into the ... considerations, interaction of the arginine with the proton-binding site is expected to be weaker than with the Na + ion-binding site. A strong interaction between the binding sit...

Ngày tải lên: 16/03/2014, 06:20

... protein. The arrowhead indicates the position of the ssDNA in the absence of SSB protein and the subsequent retardation of the band with an increasing amount of SSB is also shown. *Position of ... concentration of HpSSB, the excess multi- meric HpSSB in the vicinity of fork structure may Fig. 2. In vivo function of HpSSB. (A) Expression of EcSSB and HpSSB (wild...

Ngày tải lên: 30/03/2014, 02:20