báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx

... pathway [22]. In the present study, we observed that Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells. Osthole-induced G2/M arrest and apoptosis were associated with inhibition ... Clinical Cancer Research 2011, 30:33 http://www.jeccr.com/content/30/1/33 Page 5 of 7 RESEARC H Open Access Osthole induces G2/M arrest and apoptosis in...

Ngày tải lên: 10/08/2014, 10:21

... 90%) and the 4D cumulative DVH (Case 1). For the 50% phase, the diaphragm started moving superiorly into the field, causing less lung being irradiated at this phase, thereby reducing the lung ... motion is reduced to be within cer- tain range (< 1 cm) by applying a motion-reducing tech- nique, such as abdominal compression which is often used in stereotactic lung treatments,...

Ngày tải lên: 09/08/2014, 08:23

... staining. The tumors in the BCSCs group were positive for both EMA and SMA, indicating that they were included of both luminal epithelial and myoepithelial cells. On the other hand, the tumors in ... miR-296, miR-21 and miR-373* have been reported to be expressed in human embryo- nic stem cells and o ther stem cells, indicating that these miRNAs may play a co nstitutive role...

Ngày tải lên: 10/08/2014, 10:20

... parafor- maldehyde in PBS (pH 7.4) and mounted in Vectashield mounting medium with 1.5 Ag/mL 4V, 6-diamidino-2- phenylindole (Vector Laboratories, Inc., Burlingame, CA). The cells were stained by method ... ± 0.5%), indicating a rapid G2/M arresting activity (Table 1, Figure 2). It was accompanied by slight incline of S phase and marked decline of G0/ G1 phase (Table 1, Figure...

Ngày tải lên: 09/08/2014, 09:20

... the tyrosine 17 kinase activity in HeLa lysates. C-YES also phosphorylated cyclin dependent kinase 4 when transfected into HCT116 cells, and treatment of cells with Src family kinase inhibitors ... kinase with p34cdc2. Cancer Res 56, 3617–3621. 32 Yuan ZM, Huang Y, Kraeft SK, Chen LB, Kharbanda S & Kufe D (1996) Interaction of cyclin-dependent kinase 2 and the Lyn tyrosine kina...

Ngày tải lên: 18/02/2014, 18:20

... proteins and peptides, including immunoglobulins, lysozyme and other antibacterial enzymes, in the milk of higher animals [7,10–18]. In this context, marsupial whey proteins have been exam- ined ... muscarinic blocker atropine was investigated. Atropine had no effect on the response of CCK-8, but substantially reduced the response to euge- nin, indicating that eugenin is indeed acting...

Ngày tải lên: 19/02/2014, 16:20

... sperm-binding activity using in vitro competition and sperm-bead binding assays [18]. We deduced the amino acid sequence of the bovine ZPA by cDNA cloning and sequencing, and revealed that bovine ... sites in ZP domain among ZP components. N-glycosylation sites of bovine ZPA and porcine ZPB [10,11] and ZPC [13] in the ZP domains are shown by filled black boxes. Arrows and...

Ngày tải lên: 21/02/2014, 03:20

... routine of the algorithm which contains the grammar as the actual parsing algorithm and to view the remaining portions as forms of input data. 5. Leaving aside the matters of rule format and ... executive main routine with appropriate subroutines. This raises the further question of the functions and design of the executive routine and sub- routines. In this type of parsing p...

Ngày tải lên: 07/03/2014, 18:20

... total of 204 min- utes of audiovisual and psychophysiological re- cordings (electrocardiogram and derived heart rate value, and skin conductance). Our goal is reaching 12 recordings in the confederate ... partner’s intentions and goals in the task performance. This involves longer ut- terances, and of course a larger effort; •responsibility of maintaining a known track of c...

Ngày tải lên: 08/03/2014, 01:20

... for hydrolysis and synthesis of penicillin G, ampicillin and cephalexin. Furthermore, insight into the nature of the transition state in the rate-determining steps of the reaction was obtained by analysing ... the kinetic properties of the enzyme and mutants [4,9–13], investiga- tions into the individual rate and binding constants underlying the kinetic properties and biocatalyt...

Ngày tải lên: 08/03/2014, 08:20