A–Z of Haematology - part 9 potx

... 210 Table 16 Some of the genetic causes of severe combined immunodeficiency. Defect Deficiency of Janus-associated kinase 3 Deficiency of common γ chain of receptors for IL-2, IL-4, IL-7, IL -9 and IL ... rearrange- ment of the regions of an immunoglo- bulin or T-cell receptor gene (see Fig. 46, p. 135) red cell an erythrocyte, a non-nucleated cell of the peripheral blood the...

Ngày tải lên: 10/08/2014, 08:21

... 113 Glucose ATP ADP Hexokinase Glucose-6-phosphate Fructose-6-phosphate Fructose-1,6-diphosphate Glyceraldehyde- 3-phosphate 1,3-biphosphoglycerate 3-phosphoglycerate 2-phosphoglycerate Phosphoenolpyruvate Pyruvate Lactate Dihydroxyacetone phosphate Haemoglobin Methaemoglobin ATP ADP Glucosephosphate ... is mutated in about 10% of cases of multiple myeloma and in about 10% of cases of...

Ngày tải lên: 10/08/2014, 08:20

... transformation of myelopro- liferative disorders, forming AML 1- EAP, AML1-EVI1 and AML-MDS1 • part of ETV6 to form a fusion gene, ETV6-AML1 (TEL-AML1), detected in about 30% of cases of acute lymph- oblastic ... locus) -3 -N-acetyl D galactosylaminyltransferase (encoded by A 1 allele* at the ABO locus) AB (b) Locus Allele Transferase FUT1 ABO H h A B O -2 -L-fucosyltrans...

Ngày tải lên: 10/08/2014, 08:20

... cells of the majority of cases of B-lineage acute lymphoblastic leukaemia, more weakly on the blast cells of some cases of T-lineage acute lymphoblastic leukaemia, on the cells of many cases of ... cells of T-lineage prolympho- cytic leukaemia and, less often, the cells of other T-lineage leukaemias/lymphomas; it is expressed on blast cells of a significant minority (c. 15...

Ngày tải lên: 10/08/2014, 08:20

... cells CD 29 a glycoprotein, platelet GpIIa; β 1 integrin chain; the β chain of VLAs (very late activation antigens) including VLA-1 (CD49a/CD 29) , VLA-2 (CD49b/CD 29) , VLA-3 (CD49c/CD 29) and VLA-4 (CD49d/CD 29) ; ... cells of a sig- nificant minority of cases of classical Hodgkin’s disease CD79b part of the B-cell antigen receptor complex; crucial for the correct intra- cellula...

Ngày tải lên: 10/08/2014, 08:20

... ex- pression in about a third of cases of acute leukaemia and chronic granulocytic leuk- aemia, particularly in blast crisis DDAVP 1-deamino-6-D-arginine vaso- pressin, desmopressin acetate D-dimer ... deletion of part of a chromo- some, either part of the long arm or part of the short arm (del) (ii) deletion of a DNA sequence with the regions on either side being rejoined...

Ngày tải lên: 10/08/2014, 08:20

... Zav a , Hc a ) HPA-6w HPA-6bw (previously Ca a , Tu a ) IIIa HPA-7w HPA-7bw (previously Mo) IIIa HPA-8w HPA-8bw (previously Sr a ) IIIa HPA-9w HPA-9bw (previously Max a ) IIb HPA-10w HPA-10bw (previously ... located HNA-1 HNA-1a (previously NA1) FcγRIII (CD16) HNA-1b (previously NA2) HNA-1c (previously SH) HNA-2 HNA-2a (previously NB1) Gp58–64, a GPI-linked glycoprotein HNA-3 HNA-3a (previous...

Ngày tải lên: 10/08/2014, 08:20

... central part of a bone composed of an anastomosing network of trabecular or cancellous bone (ii) the central part of the kidney (iii) the central part of a lymph node (iv) the central part of the ... t(6;11)(q21;q23) • MLL-AF6q27 in t(6;11)(q27;q23) • MLL-AF9 in t (9; 11)(p22;q23) • MLL-AF9q34 in t (9; 11)(q34;q22) • MLL-ABI1 in t(10;11)(p11.2;q23) • MLL-AF10 in t(10;11)(p...

Ngày tải lên: 10/08/2014, 08:21

... in blast cells of 88% of cases of acute lym- phoblastic leukaemia and 97 % of cases of acute myeloid leukaemia. Wolman’s disease an inherited meta- bolic disorder, a juvenile form of choles- terol ester ... patients of any blood group, i.e. an O Rh D-negative donor (without a high titre of anti-A or anti-B antibodies) universal precautions an approach to prevention of tran...

Ngày tải lên: 10/08/2014, 08:21

... replaced by Count Odo, the defender of Paris, and his own nephew Arnulf. CHARLES IV THE SIMPLE (8 79 92 9). King of the West Franks 898 92 2, Charles was the grandson of Charles II the Bald. His most famous ... large number of 11th-century rune-stones (see rune) testify to the exis- tence of Christians in eastern Sweden, paganism also persisted in parts of this area, around the c...

Ngày tải lên: 02/07/2014, 04:21