A–Z of Haematology - part 9 potx
A–Z of Haematology - part 9 potx
... 210Table 16 Some of the genetic causes of severe combined immunodeficiency.DefectDeficiency of Janus-associated kinase 3Deficiency of common γ chain of receptors for IL-2, IL-4, IL-7, IL -9 and IL ... rearrange-ment of the regions of an immunoglo-bulin or T-cell receptor gene (see Fig. 46,p. 135)red cell an erythrocyte, a non-nucleatedcell of the peripheral blood the main func-tion of which ... pres-ence of von Willebrand’s factorristocetin cofactor assay a quant-ification of the ability of plasma to supportristocetin-induced platelet aggregation,indicative of the concentration of...
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A–Z of Haematology - part 5 potx
... 113GlucoseATPADPHexokinaseGlucose-6-phosphateFructose-6-phosphateFructose-1,6-diphosphateGlyceraldehyde-3-phosphate1,3-biphosphoglycerate3-phosphoglycerate2-phosphoglyceratePhosphoenolpyruvatePyruvateLactateDihydroxyacetonephosphateHaemoglobinMethaemoglobinATPADPGlucosephosphate ... is mutated in about10% of cases of multiple myeloma and in about 10% of cases of non-Hodgkin’slymphoma, particularly MALT-typenon-Hodgkin’s lymphoma and extra-nodal B-lineage diffuse large ... duplication 90 double helixHAE-D 01/13/2005 05:10PM Page 90 108 FYType 1disaccharide(mainly in plasma)GenotypeAA SeSe LeLe -2 -L-fucosyltransferase(encoded by Seat FUT2 locus) -3 /4-L-fucosyltransferase(encoded...
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A–Z of Haematology - part 1 pptx
... transformation of myelopro-liferative disorders, forming AML 1- EAP, AML1-EVI1 and AML-MDS1• part of ETV6 to form a fusion gene,ETV6-AML1 (TEL-AML1), detected in about 30% of cases of acute lymph-oblastic ... locus) -3 -N-acetyl Dgalactosylaminyltransferase(encoded byA1 allele* at theABO locus)AB(b)Locus Allele TransferaseFUT1ABOHhABO -2 -L-fucosyltransferasenil -3 -N-acetyl-D-galactosaminyltransferasenil -3 -D ... lineages.HAE-A 01/13/2005 05:09PM Page 8ContentsPreface, viiOnline Resources, ix A–Z of Haematology, 1vHAE-(pre) 01/13/2005 05:09PM Page vOnline ResourcesGeneral haematology American Society of...
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A–Z of Haematology - part 2 docx
... cells of themajority of cases of B-lineage acute lymphoblastic leukaemia, more weakly onthe blast cells of some cases of T-lineageacute lymphoblastic leukaemia, on thecells of many cases of ... cells of T-lineage prolympho-cytic leukaemia and, less often, the cells of other T-lineage leukaemias/lymphomas; itis expressed on blast cells of a significantminority (c. 15%) of cases of acute ... apoptosis; the anti-apoptotic activ-ity of the BCL2 protein is enhanced byphosphorylation, but its precise mechan-ism of action is not known; the archety-pal member of a family of genes encodingproteins...
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A–Z of Haematology - part 3 pdf
... cellsCD 29 a glycoprotein, platelet GpIIa; β1integrin chain; the β chain of VLAs (verylate activation antigens) including VLA-1(CD49a/CD 29) , VLA-2 (CD49b/CD 29) ,VLA-3 (CD49c/CD 29) and VLA-4(CD49d/CD 29) ; ... cells of a sig-nificant minority of cases of classicalHodgkin’s diseaseCD79b part of the B-cell antigen receptorcomplex; crucial for the correct intra-cellular assembly and transport of thecomplex; ... of atopic individuals show up-regulation of CD 89 CD90 Thy-1, a glycosylphosphatidylinosi-tol (GPI)-anchored glycoprotein expressedon lymphocytes and co-expressed withCD34 on a proportion of...
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A–Z of Haematology - part 4 ppt
... ex-pression in about a third of cases of acuteleukaemia and chronic granulocytic leuk-aemia, particularly in blast crisisDDAVP 1-deamino-6-D-arginine vaso-pressin, desmopressin acetateD-dimer ... deletion of part of a chromo-some, either part of the long arm or part of the short arm (del) (ii) deletion of aDNA sequence with the regions on eitherside being rejoineddementia loss of higher ... lymphoproliferative syn-drome (see also CD95)CD179a a protein, VpreB, expressed onvery early B-cell precursors, pro-B andearly pre-B cells where, together withCD179b, it complexes with CD79a,CD79b and...
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A–Z of Haematology - part 6 pps
... Zava, Hca)HPA-6w HPA-6bw (previously Caa, Tua) IIIaHPA-7w HPA-7bw (previously Mo) IIIaHPA-8w HPA-8bw (previously Sra) IIIaHPA-9w HPA-9bw (previously Maxa) IIbHPA-10w HPA-10bw (previously ... locatedHNA-1 HNA-1a (previously NA1) FcγRIII (CD16)HNA-1b (previously NA2)HNA-1c (previously SH)HNA-2 HNA-2a (previously NB1) Gp58–64, a GPI-linked glycoproteinHNA-3 HNA-3a (previously5b) Gp70 95 HNA-4 ... composed of repeats of branched poly-N-acetyllactosaminoglycan,on adult red cells, produced by the action of -1 ,6-N acetylglucosaminyl transferaseon i antigenI-branching ββ -1 ,6-N acetylglucosaminyltransferasean...
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A–Z of Haematology - part 7 ppt
... central part of a bonecomposed of an anastomosing network of trabecular or cancellous bone (ii) thecentral part of the kidney (iii) the central part of a lymph node (iv) the central part of the ... t(6;11)(q21;q23)• MLL-AF6q27 in t(6;11)(q27;q23)• MLL-AF9 in t (9; 11)(p22;q23)• MLL-AF9q34 in t (9; 11)(q34;q22)• MLL-ABI1 in t(10;11)(p11.2;q23)• MLL-AF10 in t(10;11)(p12;q23)• MLL-LARG by interstitial ... platelets and neu-trophil inclusions resulting from a muta-tion in the non-muscle myosin heavychain 9 gene (NMMHC-A or MYH9) at22q1 1-1 3 (or 22q12.3-q13.2)MBL the gene encoding mannose-bindinglectinMcAb...
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A–Z of Haematology - part 10 doc
... inblast cells of 88% of cases of acute lym-phoblastic leukaemia and 97 % of cases of acute myeloid leukaemia.Wolman’s disease an inherited meta-bolic disorder, a juvenile form of choles-terol ester ... patients of any blood group, i.e. an O Rh D-negativedonor (without a high titre of anti-A oranti-B antibodies)universal precautions an approach to prevention of transmission of blood-borne ... activation of macrophagesand for T-cell mediated cytotoxicitytype 2 (Th2) helper T cell a CD4+helper T cell that secretes interleukin-4,interleukin-5, interleukin-6, interleukin -9 , interleukin-10...
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The A to Z of the Vikings 9 potx
... replaced by Count Odo, the defender of Paris, and his ownnephew Arnulf.CHARLES IV THE SIMPLE (8 79 92 9). King of the West Franks 898 92 2, Charles was the grandson of Charles II the Bald. His mostfamous ... largenumber of 11th-century rune-stones (see rune) testify to the exis-tence of Christians in eastern Sweden, paganism also persisted inparts of this area, around the cult center of Gamla Uppsala, ... Angers.CHARLES III THE FAT (8 39 891 ). King of Alemannia 870, kingand emperor in Italy 880, king of the East Franks 882, and king of theWest Franks 884, Charles was the great-grandson of Charlemagneand...
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