Báo cáo y học: "Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1-induced in vitro metastatic and transformation activity" potx

... Access Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1- induced in vitro metastatic and transformation activity Chung-Yin Wu 1† , Chih-Ta Lin 2,3† , Min-Zu Wu 2 , Kou-Juey ... et al.: Induction of HSPA4 and HSPA14 by NBS1 overexpression contributes to NBS1- induced in vitro metastatic and transformation activit...

Ngày tải lên: 10/08/2014, 05:21

... chronic inflammatory disease of unknown etiology that targets the synovium. Intimal lining macrophages and fibro- blast-like synoviocytes produce pro-inflammatory cytokines that contribute to synovial ... RA. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial lining hyperplasia and sublining infil- tration of inflammatory cells [1]....

Ngày tải lên: 09/08/2014, 10:20

... activated by certain classes of RNA, mainly double-stranded RNA [14]. In vertebrates the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase ... thin-layer chromatog- raphy, immunologically and by high-performance liquid chromatography. The biological activity of (2–5)A oligo- mers was verified by inhibition of the pro...

Ngày tải lên: 21/02/2014, 15:20

... potent inhibitor for the synthesis of proin- flammatory cytokines in monocytes/macrophages and T cells [11], is substantially expressed by lining macrophages and infiltrating T cells in the inflamed ... analysed by flow cytometric analysis, and the cytokine-mediated M-CSFR induction was expressed by the ratio of the mean fluorescence intensity (MFI) of M-CSFR expression...

Ngày tải lên: 09/08/2014, 08:22

... pro- file was similar to that induced by a combination of IL-1/TNF, which might indicate the involvement of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by S. aureus. S. ... expression of a 92-kD gelatinase (type V collagenase) by rheumatoid syno- vial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J...

Ngày tải lên: 09/08/2014, 08:23

... process during embryonic development and is often accompanied by apoptosis in certain time windows. Vertebrate embryos, including Figure 3 Quantification of cell cycle-related gene expressions in tbx5 ... in vitro [30]. Our results revealed tbx5 insufficiency ultimately resulted in activation of apoptosis and inhibition of cell growth in whole individual of zebrafish...

Ngày tải lên: 10/08/2014, 10:20

... ubiquitylated by E-cadherin-binding E3 ubiqiutin ligase upon Src activation, ultimately leading to endocytosis of the E-cadherin complex. Accordingly, in the course of Decma-induced disruption of ... a nonredundant and isoform-specific role for Shc in the Erk signaling induced by the E-cadherin blockage. Decma-induced Shc tyrosine phosphorylation and its binding to Grb2 w...

Ngày tải lên: 19/02/2014, 05:20

... [23]. In addition, the protein has no hydropho- bic segment and its free energy of partitioning into membranes can be accounted for by the insertion of its myristoyl group [11]. Myristoylated ... using a myristoylated N-terminal peptide of NAP-22, Myristoyl-GGKLSK KKKGYNVNDEKAK-amide. It is known that in vivo, in addition to the intact NAP-22 protein, a significant amount of...

Ngày tải lên: 07/03/2014, 17:20

... supported by the existence (at least in Ets-1 and Ets-2) of an auto- inhibitory domain w hich, in t he absence of a ccessory factors, prevents Ets-1 binding to DNA [ 10,17]. W hen this d omain i s removed, ... amino acids 244±331) of the auto-inhibitory domain w ere made ( Fig. 3A). These truncated proteins were shown to r eadily bind to ETS response elements [10]. To ve...

Ngày tải lên: 17/03/2014, 17:20

... permeability was monitored by assessing the quenching of calcein dye trapped in egg phosphatidylcholine liposomes by Co 2+ , as described by Longland et al. [25]. Tryptophan fluorescence to follow ... FEBS 2002 Inhibition of SERCA Ca 2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca 2+ binding and phosphoryl transfer from ATP, by interfering with the pa...

Ngày tải lên: 31/03/2014, 23:20