Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons ppsx

... RESEA R C H Open Access Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons Shahrooz Vahedi 1 , Mehrnoosh Rajabian 1 , ... midbrain dopaminergic neurons. Genetic association studies have linked 13 human chromosomal loci to Parkinson’s disease. Identification of gene( s), as part of the etiology...

Ngày tải lên: 10/08/2014, 05:21

... role of Parkin gene variations in the late-onset form of PD (age of onset >45 years): Parkin mutations appear to contribute to the com- mon late-onset form and mutations, especially in exon ... functional investigations of the PINK1 protein are necessary to identify potential interac- tion partners as candidates for additional mutation screening. Conclusion Investigations of ot...

Ngày tải lên: 11/08/2014, 08:20

... the effect of STN stimulation alone, comparisons were made between DBS OFF (Deep Brain Stimulation turned off) and DBS ON after an overnight withdrawal of anti-PD medication. The Wilcoxon matched-pairs ... postural control in Parkinson's disease, whereas medication does not. Mov Disord 2006, 21:1088-1097. 47. Magnusson M, Johansson K, Johansson BB: Sensory stimulation promotes no...

Ngày tải lên: 19/06/2014, 08:20

... not simply a consequence of bradykinesia. Introduction Falls are one of the most serious complications of the gait disturbance in Parkinson's disease (PD) [1-7]. Beyond the acute trauma that ... patients or con- trols), the walking condition (e.g., treadmill or walker), walking speed, and the interaction term group × walking condition × walking speed. P values reported are based...

Ngày tải lên: 19/06/2014, 10:20

... clin- ical value of the S-VS. Abbreviations PD Parkinson's disease S-VS step-synchronized vibration stimulation VD vibratory device CV coefficient of variation CoP center of pressure UPDRS ... Access Research Effect of step-synchronized vibration stimulation of soles on gait in Parkinson's disease: a pilot study Peter Novak* 1 and Vera Novak 2 Address: 1 Department...

Ngày tải lên: 19/06/2014, 10:20

... and correspondent p values are reported. Results Comparison of gait parameters among the baseline condi- tion (BL), the conditions with continuous optic flow (BOF, FOF) and the condition implying ... Parkinson's Disease. Com- parison of gait velocity, stride length and cadence between the baseline condition (BL), the conditions involving optic flow (BOF, FOF) and the condition inv...

Ngày tải lên: 19/06/2014, 10:20

... cells and under the conditions of the Salmonella/reversion assay, as demonstrated previously by some of these workers. A number of genes important for expression of detoxification and antioxidant defense ... stress; (4) inhibition of cancer cell proliferation and induction of apoptosis; (5) regulation of subcellular signaling pathways and modulation of transcription factors;...

Ngày tải lên: 25/10/2013, 05:20

... degradation and 71: THE ETIOPATHOGENESIS OF PARKINSON’S DISEASE: BASIC MECHANISMS OF NEURODEGENERATION consider that alterations in the a-synuclein gene can inter- fere with the clearance of unwanted ... oligomeri- zation, not fibrillization, is a shared property of both alpha- synuclein mutations linked to early-onset Parkinson’s disease: implications for pathogenesis and th...

Ngày tải lên: 14/02/2014, 17:20

... Rotenone model of Parkinsonism – the five years inspection 269 Schmidt, W. J., Alam, M.: Controversies on new animal models of Parkinson’s disease Pro and Con: the rotenone model of Parkinson’s disease ... discharge rates of neurons in the basal ganglia output nuclei and in the STN are increased in Parkinson’s disease has been generally confirmed in ani- mal models of...

Ngày tải lên: 14/02/2014, 17:20

... LB is a general hallmark of the PD state, suggesting that the accumula- tion of a-synuclein might cause selective degeneration of dopaminergic neurons [1,4]. Expression of either wild-type or mutant ... (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association of dopamine treatment with a...

Ngày tải lên: 15/02/2014, 01:20