sleep in parkinson s disease

... Autosomal recessive genes in Parkinson s disease Protein phosphorylation and signalling pathways PINK1 has a strongly predicted, conserved serine ⁄ threonine kinase domain [12] and has been shown ... essential role for Parkin in oxidative stress [77] and Drosophila Parkin mutants show increased sensitivity to oxidative stress [78] Implication of PINK1 in oxidative stress processes has also ... has been described [16,17] PINK1 is of great interest to research into mitochondrial dysfunction in PD PINK1 Autosomal recessive genes in Parkinson s disease contains a putative catalytic serine–threonine...

Ngày tải lên: 18/02/2014, 14:20

... a fellowship from the American Parkinson s Disease Association A.B.W is supported by the Michael J Fox Foundation for Parkinson s Disease Research, the American Parkinson s Disease Association, ... variants segregate with disease in large families The most common of the known LRRK2 mutations (G201 9S) increases in vitro kinase activity, analogous to mutations in the same kinase subdomain in ... kinase domain that inactive kinase activity likewise reduces toxicity In one cell model, LRRK2 expression may cause increases in caspase-8 activation as a result of a kinase-sensitive association...

Ngày tải lên: 23/03/2014, 04:20

... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a specific inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with ... RB, WilsonDelfosse AL & Chen SG (2007) The Parkinson s disease- associated protein, leucine-rich repeat kinase (LRRK2), is an authentic GTPase that stimulates kinase activity Exp Cell Res 313,...

Ngày tải lên: 23/03/2014, 04:20

... family-based study, but varied in subsequent reports, depending on sample size, study design, inclusion of probands in the analysis and methods of calculation To address some of these issues, Healy ... other social issues Genetic testing should preferably be supported by a multidisciplinary team with expertise in handling pre-testing and post-testing related problems A recent study has demonstrated ... a haplotype that increases disease risk when present in two copies was identified among sporadic Chinese PD population in Singapore [32] However, other studies did not reveal association with any...

Ngày tải lên: 23/03/2014, 04:20

... Epidemiologic, clinical, and therapeutic aspects of Parkinson s disease Parkinsonism and Parkinson s disease 34 Cognitive deficits in Parkinson s disease 55 Depression in Parkinson s disease 88 Anxiety, ... guidelines, case studies and rating scales will meet the needs of all clinicians working with Parkinson s disease patients Sergio E Starkstein was Assistant Professor of Psychiatry at Johns Hopkins ... the disease itself This subject is further discussed in chapter Clusters of parkinsonian signs and subgroups of the disease A question now arising is whether PD constitutes one single and clinically...

Ngày tải lên: 28/03/2014, 22:21

... tissues were dissected from embryonic brain and trypsinized into single-cell suspension using sterilized micropipette tips The cells were resuspended in DMEM and Ham 's F12 at 1:1 (D-F12), supplemented ... expression, 15 mg wet tissues with microcarriersRPE cells and tissues with microcarriers were lysed for ELISA assay The lysis buffer was prepared according to the manual in a ratio of mg tissue ... used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at p < 0.05 Results RPE-CM protects against rotenone and...

Ngày tải lên: 18/06/2014, 15:20

... blow, sudden loss of consciousness, or paralysis [14] - Posture and Gait Score: This score includes questions 13-15 and 29-30 of the UPDRS, and has been used as an outcome measure to assess gait ... extremities [7] - Parkinson s Disease Questionnaire-39 (PDQ-39): This questionnaire examines dimensions of quality of life specific to PD patients and is scored on a 5point scale As a disease- specific ... Guillory S, Kostic V, Fahn S: Motor blocks in Parkinson s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations...

Ngày tải lên: 19/06/2014, 08:20

... Hassanein R: Falls and Parkinson' s disease Clin Neuropharmacol 1989, 12:98-105 Bloem BR, Hausdorff JM, Visser JE, Giladi N: Falls and freezing of gait in Parkinson' s disease: a review of two interconnected, ... an increased fall risk in older adults in general, as well as in patients with PD [9-13], suggesting that this aspect of gait may have clinical utility as an aid in fall risk assessment More specifically, ... patients with Parkinson' s disease J Geriatr Psychiatry Neurol 2003, 16:53-58 Schaafsma JD, Giladi N, Balash Y, Bartels AL, Gurevich T, Hausdorff JM: Gait dynamics in Parkinson' s disease: relationship...

Ngày tải lên: 19/06/2014, 10:20

... sub-phases of the step Study Protocol The walking trials were done in the on medication state in PD subjects The insoles with VDs were inserted into the subject 's shoes Subjects walked for minutes ... Conclusion This study indicates that the step-synchronized vibration stimulation of the soles improves gait steadiness in Parkinson' s disease patients with predominant balance impairment The suprathreshold ... S, Cody F, O'Boyle D: Joint position sense is impaired by Parkinson' s disease Ann Neurol 2000, 47:218-228 Schneider JS, Diamond SG, Markham CH: Parkinson' s disease: sensory and motor problems...

Ngày tải lên: 19/06/2014, 10:20

... Progression of Parkinson s Disease Figure stimuli Schematization of responsiveness of PD subjects to visual Schematization of responsiveness of PD subjects to visual stimuli The diagram represents schematically ... Fahn S: Motor blocks in Parkinson' s disease Neurology 1992, 42:333-339 Lewis GN, Byblow WD, Walt SE: Stride length regulation in Parkinson' s disease: the use of extrinsic, visual cues Brain 2000, ... controls in response to an attentional stimulus (increasing stride length, decreasing cadence), would suggest that, in advanced stages of disease, as a consequence of progression of motor symptoms,...

Ngày tải lên: 19/06/2014, 10:20

... diagnosis (up to years versus more than years; years was the sample median disease duration) Scale scores were compared across these groups and statistical significance was assessed using the independent ... Component Summary; PD: Parkinson s disease; PDQ-8: Parkinson s Disease Questionnaire-8; RMSEA: root mean square error of approximation; SCOPA-DC: Scales for Outcomes of Parkinson s disease Diary ... 3-day item scores for the items within the respective subscale If at least one of the 3-day item scores was missing the subscale score was set to missing In all cases, higher scores indicate greater...

Ngày tải lên: 20/06/2014, 15:20

... motor disorders, such as Parkinsons disease Thus, in PD, the loss of dopamine neurons causes the subsequent loss of striatal dopamine, and the presentation of motor symptoms, such as bradykinesia, ... Rocớo/CSIC/Universidad de Sevilla, Spain Introduction Parkinsons disease (PD) was first described in 1817 by James Parkinson, who described in his monograph entitled An Essay on the Shaking Palsy ... underlying Parkinsons disease and L-DOPA-induced dyskinesia New intervention strategies focused on modifying the disease process, as opposed to the current symptom-alleviating management of the disease, ...

Ngày tải lên: 27/06/2014, 13:20

... a place in the classification of nosologists Some have regarded its characteristic symptoms as distinct and different diseases, and others have given its name to diseases differing essentially ... the disease itself? Varied populations included in the studies (different stages of parkinsonism, absence of standard definition of PD itself) may be another cause for discrepancies [36] James Parkinson ... errors in separating idiopathic Parkinson' s disease from other causes of the akinetic-rigid syndrome, or errors in differentiating dementia from confusional states, depression and even ageing,...

Ngày tải lên: 08/08/2014, 21:20

... Parkinson s disease A seminal discovery in the study of PD was the report of missense mutations in the SNCA gene, encoding the αsynuclein protein, in dominantly inherited disease [6] This was the ... Hardy J, Gwinn-Hardy K: alpha-Synuclein locus triplication causes Parkinson s disease Science 2003, 302:841 Farrer MJ: Genetics of Parkinson disease: paradigm shifts and future prospects Nat Rev ... PD, Parkinson s disease; SNP, single nucleotide polymorphism Competing interests The authors declare that they have no competing interests Authors’ contributions MT and OAR drafted the manuscript...

Ngày tải lên: 11/08/2014, 12:20

... oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors Hum Mol ... displayed quantitative differences, regardless of whether or not a-synuclein was overexpressed (Fig 2, insets; black versus white bars) Dopamine-responsive proteins were involved in protein synthesis, ... Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: an increase in lamin A ⁄ C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced...

Ngày tải lên: 15/02/2014, 01:20

... intracellular cholesterol trafficking Transferase activity ATPase Dopamine transmission and synaptic vesicle dynamics Protein kinase Gaucher s disease ⁄ Parkinson s disease in heterozygotes Neurodegeneration ... DES, desaturase; GALC, galactosylceramidase; GBA, glucosylceramidase; GCS, glucosylceramide synthase; SMS, sphingomyelin synthase; SMse, sphingomyelinase; SPT, serine palmitoyl transferase Yellow ... calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry...

Ngày tải lên: 18/02/2014, 14:20

... as salsolinol [23] In line with the suggested role of ADHs and ALDHs in protection against toxic insults, mRNAs encoding these enzymes have previously been identified in tissues forming a physiological ... Vos RA, Del Bohl J & TK (2006) Gastric alpha-synuclein immunoreactive inclusions in Meissner s and Auerbach s plexuses in cases staged for Parkinson s disease- related brain pathology Neurosci ... the Swedish Parkinson Foundation, Swedish Brain Power, Bjorn ¨ Oscarssons Stiftelse, USPHS grants and Karolinska Institutet Funds The Adh4 knockout mice were kindly provided by Dr Gregg Duester...

Ngày tải lên: 16/03/2014, 11:20

... Representative – Parkinson s Disease Society Jacqui Handley (GDG member) Parkinson s Disease Nurse Specialist Dorset County Hospital, Dorchester Parkinson s Disease Nurse Specialist Association John Hindle ... diagnosis at regular intervals (6–12 months) Throughout disease Diagnosis and early disease Disease progression Parkinson s disease algorithm Figure 3.1 Parkinson s disease algorithm: interventions ... Parkinson s Disease Society Campaigns and Information Parkinson s Disease Society (Attended ten meetings) David McNiven (GDG member) Policy and Campaigns Manager Parkinson s Disease Society Parkinson s...

Ngày tải lên: 31/03/2014, 13:20

... net training time of 30-45 minutes in each session Assessments Assessments included standardized tests of balance and, postural control as well as ADL s to evaluate the effects of training Balance ... rise (5CR) test was used to assess the ability to perform sit-to-stand and stand-to-sit transfers Patients were instructed to stand up and sit down five times as fast as possible Page of starting ... received several training sessions (up to training sessions) in their home to explore the possibility for future independent home training with the ABF system The home sessions were performed in the...

Ngày tải lên: 19/06/2014, 08:20

... Comorbidity Postural hypotension5 Prior surgery related to Parkinson' s disease6 Pain symptoms Assistive device (walking indoors) Assistive device (walking outdoors) Falls within the past months7 Median ... minutes in- between the tests (eyes open, eyes closed) The same test order was maintained during the DBS OFF and ON measurements In every test situation, spontaneous sway was recorded for 30 seconds ... falls in Parkinson' s disease Journal of Neurology 2001, 248:950-958 Gray P, Hildebrand K: Fall risk factors in Parkinson' s disease J Neurosci Nurs 2000, 32:222-228 Ashburn A, Stack E, Pickering...

Ngày tải lên: 19/06/2014, 08:20