PKCα mediated induction of miR-101 in human hepatoma HepG2 cells docx

... level of induction at 48 hrs. The rapid induction of miR-101 by TPA treatment indi- cates that the induction of miR-101 may be the primary response of TPA treatment in HepG2 cells (Fig 2C). TPA-induced ... wide level. In this study, we examined TPA regulated miRNA expression profile in human hepatoma HepG2 cells and discovered that miR-101 was induced by...

Ngày tải lên: 10/08/2014, 05:21

... drug daunorubicin (DNR) on the induction of apoptosis using drug-resistant human hepatoma HepG2/ ADM cells. Electrochemical assay revealed that Cdte QDs readily facilitated the uptake of the DNR into HepG2/ ADM ... results provideevidencethattheremarkableenhancementof apoptosis was induced by synergistic effects of Cdte QDs and DNR on HepG2/ ADM cells. Signal pathway of t...

Ngày tải lên: 21/06/2014, 03:20

... with an accompanying inhibition of cyclin E/cdk2 and cyclin B1/cdk1 levels. Evidence supporting the induction of apoptosis by LA was based on the appearance of sub-G 1 peak in flow cytometry ... expression in 48 h LA treated cells. (D) The actin-adjusted level of bax and bcl-2 and changes in the ratio of bax to bcl-2 in HL-60 cells treated for 48 h with increasing do...

Ngày tải lên: 10/08/2014, 22:20

... resulted in a 63% reduction in the number of infected cells, while at doses of 1 μg/ml and 10 μg/ml of Poly I:C, >97% reduction in the number of infected cells was observed (Fig. 1C). In contrast, ... HCMV infection. In the absence of IFNβ neutralizing antibody, The effect of time of TLR stimulation on HCMV infection and IL-8 secretion in Foreskin FibroblastsFi...

Ngày tải lên: 20/06/2014, 01:20

... chemokines in monocytes and macrophages (including Kupffer cells) [41, 42], and ethanol-induced mucosal injury in the upper gastrointestinal tract leading to increase in the permeability of ... . Interestingly, HMGN3 has been found to be associated with resistance against anticancer drugs including vinblastine, topotecan, paclitaxel and doxorubincin in human hepatocellular...

Ngày tải lên: 31/10/2012, 15:28

... the release of cytokines upon V. cholerae infection in intes- tinal epithelial cells. Reports have shown the induction of IL-8 in intestinal epithelial cells upon V. cholerae infection [11–13]. The induction ... does indeed induce a range of cytokine expression in intesti- nal epithelial cells upon infection. Comparison of the status of induction of cytokines by q...

Ngày tải lên: 18/02/2014, 16:20

... recognition in the normal splicing process [55]. First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of the ATM ... Italy Introduction Towards the end of the 1970s, in the beginning of pre-mRNA splicing research [1,2], defining exons and introns was essentially based on observing the final composi...

Ngày tải lên: 06/03/2014, 09:22

... Guanine nucleotide-binding protein (G protein), c11 22 PQBP1 NM_005710 2.232 Polyglutamine-binding protein 1 23 FKBP9 NM_007270 2.212 FK506-binding protein 9 24 PSPHL NM_003832 2.212 Phosphoserine ... sensitive parent cell line with PYM over a period of 2 years. At the beginning of induction, cell growth was strongly sup- pressed. However, at the end of induction, Tca8113 ⁄ PYM cells...

Ngày tải lên: 06/03/2014, 22:21

... explain their wide distribution in tissues and cells [16], including stem cells [17]. Increasing evidence links these noncatalytic actions with the binding of cholinesterases to several protein partners. ... extent of binding with the lectins concanavalin A, Lens culinaris agglutinin (LCA), and Ricinus communis agglutinin (RCA) (Fig. 3), ruled out the blood origin and supported the...

Ngày tải lên: 06/03/2014, 22:21

... occurs in a mitochondrial Fig. 1. Ionizing radiation induces expression of Fas and activation of caspases in human cervical cancer cells. (A) Ionizing radiation-induced apoptotic cell death. HeLa cells ... attenuated radiation-induced degra- dation of the Bcl-2 protein, indicating proteasome- dependent downregulation of Bcl-2. In addition, ubiquitination of Bcl-2 appeared...

Ngày tải lên: 07/03/2014, 05:20