Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla pps
Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla pps
... RESEA R C H Open Access Extracellular signal-regulated kinase 1/2 plays a pro-life role in experimental brain stem death via MAPK signal-interacting kinase at rostral ventrolateral medulla Samuel ... article as: Chan et al.: Extracellular signal-r egulated kinase 1/2 plays a pro-life role in experimental brain stem death via...
Ngày tải lên: 10/08/2014, 05:21
Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla pps
... cellular and molecular mechanisms that underpin brain stem death. A suitable neural substrate for mechanistic delineation on brain stem death resides in the rostral ventrolateral medulla (RVLM) ... Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolater...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
... indicate that TM12 plays a key role in the progression of the ATP hydrolytic cycle in ABCB1 and, in particular, in coordinating conformational changes between the NBDs and transmembrane domains. Abbreviations ABC, ... label- ling according to the following relationship: t 1=2 ¼ Ln2 = k Statistical analysis All data manipulations and statistical analyses were per- formed using gr...
Ngày tải lên: 06/03/2014, 22:21
Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... c (PPARc) and CCAAT ⁄ enhancer-binding protein a (C ⁄ EBPa) play important roles as master regulators [12]. In terminal differentiation, PPARc and C⁄ EBPa transactivate each other and upregulate ... translation initiation (A/ GCC ATGA/G). A 1809 bp cDNA fragment con- taining a stop codon was isolated by RT-PCR. A 1007 bp cDNA containing a poly (A) tail was obtained by 3¢ RACE. By...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Peroxisome proliferator-activated receptor a plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors docx
... 5¢-TCAAGAATGGATACACATAAA CACAAGGA-3¢ for Cyp2c29; 5¢-CCAGCTCTGCTTCAT TCCTCTCT-3¢ and 5¢-CGCAGGAATGGATAAACATA AGCA-3¢ for Cyp2c38; 5¢-ACTTCTCTGTGGCAAGCCC TGTTG-3¢ and 5¢-TCCACTAGCACAGATCACAGATC ATGG-3¢ ... 5¢-TGCAGAACTTCCACTTCAA ATCCA-3¢ and 5¢-AATTTCCCCCTTCTCTGGCTACC-3¢ for Cyp 2a5 ; 5¢-TTGTTCTAAAAGTTGTGCCACGG GATG-3¢ and 5¢-AGAGATGATCCCATGAGAAACGG TGAA-3¢ for Cyp 3a4 4; 5¢-AGATCATCATTCCTTGGC...
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide ppt
... First, activation of plasma membrane LPCAT would likely result in elevated incorporation of polyunsaturated fatty acids into PtdCho. Exchange of fatty acid chains would lead to more unsaturated ... the cell walls of Gram-negative bacteria, is an important microbial molecular pattern that initiates in ammatory and coagulation reactions as part of the host innate immune response to infection...
Ngày tải lên: 31/03/2014, 01:20
Báo cáo Y học: The a1b1 contact of human hemoglobin plays a key role in stabilizing the bound dioxygen Further evidence from the iron valency hybrids potx
... con®guration, the a1 b2anda2b1 contacts undergo the principal changes associated with the cooperative oxygen binding, so that these are named the sliding contacts. At the a1 b1anda2b2 interfaces, ... spectral examinations clearly indicate that the formation of the a1 b1ora2b2 contact suppresses remarkably the a cidic a utoxidation o f the b chain, and prevents its hemichrome formatio...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo hóa học: "Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque" ppt
... unraveled a Ca 2+ -dependent pathway regulating secretion in throm- bin-stimulated human platelets linking Rac1 activation to actin dynamics: Calcineurin®Rac1 ®class-II PAKs activation®cofilin dephosphorylation ... of their granule contents such as ADP that recruits circu- lating platelets into large aggregates culminating in the formation of platelet thr ombi [5,6]. The latter are pote...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury" doc
... dramatically upregulates anti-inflammatory/Type I IFN genes, many of which are associated with IRF3, while still maintaining a pro-inflammatory response. Vartanian et al. Journal of Neuroinflammation 2011, ... responses. In contrast, TLR signaling pathways that a ctivate IRFs can induce anti- inflammatory mediators and type I I FNs that have been associated with neuroprotection [13,14]....
Ngày tải lên: 19/06/2014, 22:20
báo cáo khoa học: " The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis" potx
... Takahashi H, Watanabe-Takahashi A, Smith FW, Blake-Kalff M, Hawkesford MJ, Saito K: The roles of three functional sulphate transporters involved in uptake and translocation of sulphate in Arabidopsis ... Kataoka T, Watanabe-Takahashi A, Hayashi N, Ohnishi M, Mimura T, Buchner P, Hawkesford MJ, Yamaya T, Takahashi H: Vacuolar sulfate transporters are essential determinants controlling in...
Ngày tải lên: 11/08/2014, 11:21