Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability doc

... al., Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability Journal of Biomedical Science 2010, 17:6 Jiang et al. Journal of Biomedical ... the original work is properly cited. Research Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin...

Ngày tải lên: 10/08/2014, 05:21

... m M Tris/ HCl, pH 6.8) to dissolve cells was added to the cells, and then the cell suspension was sonicated in a bath-type sonicator for 5min. The amount of protein of the solubilized cells was determined ... endothelial cells [20–23], the mechanism of the TS effect still remains unclear. Therefore, we investigated in detail the effect of TS on NO production in t...

Ngày tải lên: 22/02/2014, 04:20

... basement membrane between smooth muscle cells resulting in damage to the basement membrane and leading to the eventual destruction of the cells [12]. The loss of VSMC may result in weakening of the vessel wall, ... characteristic of apoptosis. The extent of Ab aggregationwasshowntocorrelatewith the toxic response in the VSMC. The duration of the Ab agei...

Ngày tải lên: 22/02/2014, 07:20

... in the smooth muscle cell line. The molecular basis for activation of the AGT gene is only partially understood. The analysis of biological information presumes that the 500-bp region of the ... increased the level of angiotensinogen mRNA by 2.1-fold in vascular smooth muscle cells. The increased level of angiotensinogen mRNA occurred with concurrent ele...

Ngày tải lên: 30/03/2014, 02:20

... lesions have many features of an inflammatory process, and the proliferation of smooth muscle cells (SMC) from the medial layer of the vessel to the intima is a key event in the development o f this ... PUFAs by modulating various steps of the inflam- matory process. We have investigated the molecular mech- anisms by which the incorporation of the n-6 PUF...

Ngày tải lên: 19/02/2014, 16:20

... because of the stabilizing effect provided by R97, which is lacking in the mutant R97M. Hence, the DDG° is equal to the energy of the stabilizing effect provided by R97. Thus, based on the DpK a of ... a major cause of the shift in the pK a of E399. Therefore, R97 facilitates the ionization of the catalytic nucleophile by stabilizing its charged state. Fi...

Ngày tải lên: 23/03/2014, 15:21

... structures either in the presence of absence of dexamethasone (Figure 2C). We reported that after the assembly of Aβ fibrils on the HCSM cell surface there is a striking accumulation of cell- associated ... proteins [29-32]. Similarly, cerebral vascular smooth muscle cells, which degenerate in the presence of accumulated vascular fibrillar amyloid, may also partici...

Ngày tải lên: 19/06/2014, 22:20

... was removed by gently scratching the intimal surface with a surgical blade. The remaining smooth muscles were then digested with 1.0 mg/ml of collagenase II for 120 min at 37°C. The cells were ... in pulmonary artery smooth muscle cells (PASMCs ) and homogenates of pulmonary arteries (PAs). A. Detection of CaSR mRNA by RT-PCR in rat PASMCs in the absence or presenc...

Ngày tải lên: 10/08/2014, 05:21

... head of the Departement of Thoracic and Cardiovascular Surgery; JRS: MD, cardiologist, contribution to arrangement of the manuscript. Consent The study was approved by the local Review board of the ... summary, our data suggest that the persistently increased secretion of the inflammatory mediator GM- CSF by resident inflammatory cells but also by SMC may be t...

Ngày tải lên: 10/08/2014, 09:22

Ngày tải lên: 16/12/2012, 15:24