Ophthalmic Drug Delivery Systems - part 10 ppt

... pharmaceu- tical drug product will be essential. The commercial consideration for development of an ophthalmic drug delivery system is not limited to new therapeutic agents. Many existing ophthalmic drugs ... will vary with the particular dru g and the novelty of the particular delivery system. The approach of one company in establishing the safety/toxicity profile of ophthalmic...

Ngày tải lên: 10/08/2014, 00:20

... of a series of 5 0 -ester prodrugs of 5-iodo-2 0 -deoxyuridine. Pharm. Res. 5:734–737, 1988. 10 Macha et al. Copyright © 2003 Marcel Dekker, Inc. Ophthalmic Drug Delivery Systems Second Edition, ... effective ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding. Systems range from simple solutions to novel delivery systems such as biodeg...

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... pharmaceu- tical drug product will be essential. The commercial consideration for development of an ophthalmic drug delivery system is not limited to new therapeutic agents. Many existing ophthalmic drugs ... activity of phosphorothio- ate antisense oligonucleotides. Mol. Pharmacol. 41 :102 3 103 3. 180. O. Zelphati and F. C. Szoka, Jr. (1996). Intracellular distribution and mechan-...

Ngày tải lên: 10/08/2014, 03:20

... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiologyoftheeyeand surroundingtissue,ocularpharmacokineticsisconsiderablymoredifficult todescribeandpredictthanitssystemiccounterpart.Thetaskisfurther complicatedbythevariousformulations,routes,anddosingregimenstypi- callyencoun...

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... of compounds, including fluorescein (2:6 Â 10 À5 cm/s), fluor- escein glucuronide (4:5 Â 10 À7 cm/s), and dexamethasone sodium m-sulfo- benzoate (4:9 Â 10 À5 cm/s) (1,9,15–17,30). All of the reported ... injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, decreased signific...

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... Animal Effect 2-Phenylethanol 0.5% Tilisolol, FD-4, FD- 10 Rabbit Enhanced Papp 2.7 times for tilisolol, 5.6 times for FD-4, and 4.8 times for FD -1 0 Paraben 0.04% Tilisolol, FD-4, FD- 10 Rabbit Enhanced ... applied drugs in the rabbit. Pharm. Res. 15:1882–1887, 1998. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-...

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... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per- meation of drug across the conjunctiva and sclera and may contribute sig- nificantly ... and Ganiban, G. J. (1995). Delivery systems for intraocular routes, Adv. Drug Delivery Rev., 16 :107 –123. 129. Geroski, D. H., and Edelhauser, H. F. (2000). Review: Drug deli...

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... H. (1983). Vasopressin effects on isolated non-pregnant myometrium and uterine arteries and their inhibition by deamino-ethyl-lysine-vasopressin and dea- mino-ethyl-oxytocin, Br. J. Obstet. Gynaecol., ... near future. We hope that novel drug delivery systems will be developed to deliver potent polypeptide drugs through the ocular route. REFERENCES 1. Lee, V. H. L. (1987). Ophthalmic d...

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... adenovirus encoding brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized ... Phosphorothioate-modified oli- godeoxyribonucleotides, III. NMR and UV spectroscopic studies of the Rp- Rp, Sp-SP, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diaster- eomeric O-ethyl phos...

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