Ophthalmic Drug Delivery Systems - part 8 docx

... analogue, 1- desamino -8 - D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO-2, Int. J. Pharm., 64: 181 . 43. Amidon, G. L., Sinko, P. J., Hu, M., and Leesman, G. D. (1 989 ). ... rhodop- sin mutation were protected from apoptosis by recombinant adeno- associated virus-mediated production of fibroblast growth factors fgf-2, fgf-5, and fgf- 18 (30,31), while len...

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... applied ophthalmic drugs, Surv. Ophthalmol., 26:207–2 18. 88 . Mikkelson, T. J. (1 984 ). Review: Ophthalmic drug delivery, Pharm. Tech., 8: 90– 98. 89 . Lee, V. H. L. (1 985 ). Review: Topical ocular drug delivery recent ... Lee, V. H. L. (19 98) . Ocular absorption of pz-peptide and its effect on the ocular systemic pharmacokinetics of topically applied drugs in the rabbit, Phar...

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... including polymer -drug complex sys- tems, erodible microspheres, responsive particulates, in situ gelling systems, ion-exchange systems, and nanoparticles (15). B. Local Injectable Systems When the ... Stenzel, K. H., and Rubin, A. L. (19 78) . Soluble gentamicin ophthalmic inserts as a drug delivery system, Arch. Ophthalmol., 96 :88 5. 83 . McCoy, J. P., Jr. (1 986 ). Contempor...

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... practically unaltered. The corneal and conjunctival penetration of 4-phenylazobenzyloxy- carbonyl-l-Pro-l-Leu-Gly-l-Pro-d-Arg (Pz-peptide) and its effect on the corneal and conjunctival penetration ... near future. We hope that novel drug delivery systems will be developed to deliver potent polypeptide drugs through the ocular route. REFERENCES 1. Lee, V. H. L. (1 987 ). Ophthalmic de...

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... Na + /K + -ATPase (Usukura et al., 1 988 ; Okami et al., 1 989 ; Martin-Vasallo et at., 1 989 ), H + /K + -ATPase (Fain et al, 1 988 ) and active ascorbate transport system (Socci and Delamere, 1 988 ) are ... of a series of 5 0 -ester prodrugs of 5-iodo-2 0 -deoxyuridine. Pharm. Res. 5:734–737, 1 988 . 10 Macha et al. Copyright © 2003 Marcel Dekker, Inc. Ophthalmic Drug Delivery Syste...

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... consideration in topical ocular drug delivery. Clin. Exp. Pharmacol. Physiol., 27:5 58. 8. Schoenwald, R. D. (1993). Ocular pharmacokinetics/pharmacodynamics, Ophthalmic Drug Delivery Systems (A. K. Mitra, ... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiol...

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... injection location and the retinal permeability of the drug. If the drug has a low retinal permeability, then the half-life of the drug in an aphakic eye is highly depen- dent on the distance between the injection ... injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, de...

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... applied drugs in the rabbit. Pharm. Res. 15: 188 2– 188 7, 19 98. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... Animal Effect 2-Phenylethanol 0.5% Tilisolol, FD-4, FD- 10 Rabbit Enhanced Papp 2.7 times for tilisolol, 5.6 times for FD-4, and 4 .8 times for FD-10 Paraben 0.04% Tiliso...

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... adenovirus encoding brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized ... (19 98) . Ribozyme-targeted destruction of RNA associated with autosomal-dominant retinitis pigmentosa. Invest. Ophthamol. Vis. Sci., 39(5): 681 – 689 . 213. Tombran-Tink, J., and Johnson, L. V...

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... therapeutics: drug delivery and targeting. Adv. Drug Delivery Rev., 18: 115–131. 167. J. W. Jaroszewski, and J. S. Cohen. (1991). Cellular uptake of antisense oli- godeoxynucleotides. Adv. Drug Delivery ... integrins. Transplantation, 64:763–769. 87 . E. Wagner (1999). Application of membrane-active peptides for nonviral gene delivery. Adv. Drug Deliv. Rev., 38: 279– 289 . 88...

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