Ophthalmic Drug Delivery Systems - part 6 docx

... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per- meation of drug across the conjunctiva and sclera and may contribute sig- nificantly ... of the eye, Biomaterials., 21 :64 9 66 5. 131. Peyman, G. A., and Ganiban, G. J. (1995). Review: Delivery systems for intraocular routes, Adv. Drug Delivery Rev., 16: 107–123. 13...

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... (1990). Absorption of vasopressin analogue, 1- desamino-8-D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO-2, Int. J. Pharm., 64 :181. 43. Amidon, G. L., Sinko, P. J., ... absorption of L--methyl- dopa: Carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of L--methyldopa, Pharma. Res., 6: 66. 46. Friedman, D. I.,...

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... including polymer -drug complex sys- tems, erodible microspheres, responsive particulates, in situ gelling systems, ion-exchange systems, and nanoparticles (15). B. Local Injectable Systems When the ... PECL nanoparticles for carteolol. It was concluded that the drug entrapped in the oily core is more available for corneal absorption. 3 H-Labeled hydrocortisone-17-butyrate-21-propiona...

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... octanol-water partition coefficients. J. Pharm. Sci. 67 :7 86 788, 1978. 16. M. M. Narurkar and A. K. Mitra. Prodrugs of 5-iodo-2 0 -deoxyuridine for enhanced ocular transport. Pharm. Res. 6: 887–891, ... Brittam 96 Freeze-Drymg/Lyophilization of Pharmaceutical and Biological Prod- ucts, edited by Louis Rey and Joan C May 97. Percutaneous Absorption- Drugs-Cosmetics-Mechanism...

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... G PENETRATION INTO THE EYE Carrier-independent penetration of antibiotics and other drugs into the eye (11, 16, 23 ,63 ,81), like that at other anatomical sites ( 16, 23,53 ,63 ,66 ), is related to the physicochemical ... littlefromdrugto drug, asshowninTable7 in terms of half-life. The half-lives fall within a relatively narrow range of about 0.3 6 hours for a wide variety of drugs. Determ...

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... Arch. Clin. Exp. Ophthalmol. 228: 461 – 466 , 1990. 36. Tsukahara, Y., and Maurice, D. M., Local pressure effects on vitreous kinetics. Exp. Eye Res. 60 : 563 –574, 1995. Drug Distribution in Vitreous Humor ... perfusion with anisosmotic fluid changes the dialysate concen- tration of taurine in brain (64 66 ) and muscle (64 ) microdialysis. In addi- tion, problems arise when a compound alre...

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... applied drugs in the rabbit. Pharm. Res. 15:1882–1887, 1998. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... Cataract Refract. Surg., 25: 562 – 565 . 65 . Taravella, M. J., Stepp, P., and Young, D. A. (1998). Collagen shield delivery of tobramycin to the human eye, CLAO J., 24: 166...

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... brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63 % axotomized RGCs, indicating the ... PNAS, 85 :64 60 64 64. 83. Markowitz, D., Goff, S., and Bank, A. (1988). A safe packaging line for gene transfer: separating viral genes on two different plasmids. J. Virol. 62 :1120– 1124. 5...

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... specificity. Perspect. Drug Discov. Design, 4:41–50. 165 . R. M. Crooke. (1991). In vitro toxicity and pharmacokinetics of antisense oligonucleotides. Anticancer Drug Des., 6: 609 64 6. 166 . Y. Rojanasakul. (19 96) . ... therapeutics: drug delivery and targeting. Adv. Drug Delivery Rev., 18:115–131. 167 . J. W. Jaroszewski, and J. S. Cohen. (1991). Cellular uptake of antisense...

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