Ophthalmic Drug Delivery Systems - part 5 doc

... applied drugs in the rabbit. Pharm. Res. 15: 1882–1887, 1998. 50 . Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... Animal Effect 2-Phenylethanol 0 .5% Tilisolol, FD-4, FD- 10 Rabbit Enhanced Papp 2.7 times for tilisolol, 5. 6 times for FD-4, and 4.8 times for FD-10 Paraben 0.04% Tilisolo...

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... anterior chamber (52 ,53 ) generally exhibit half-lives within a range of 20–30 hours (53 ). The second route is through the retina via penetration of the blood-retinal barrier (52 ,53 ). Drugs eliminated ... sensitivity of drug distribution and elimination using the model. Therefore, the diffu- sivities used in the model simulations are 2:4 Â 10 5 cm 2 /s (1 25 Da), 5: 6 Â 10 À6 cm 2 /s...

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... R. (1998). Ophthalmic drug delivery systems recent advances, Prog. Retinal Eye Res., 17:33 58 . 95. Robinson, J. C. (1993). Ocular anatomy and physiology relevant to ocular drug delivery. Drugs Pharm. ... of endotoxin-induced-uvei- tis in rats. Exp. Eye Res., 65: 533 54 5. 68. Pagano, G., Bruno, A., Cavallo-Perin, P., Cesco, L., and Imbimbo, B. (1989). Glucose intolerance after sho...

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... on isolated non-pregnant myometrium and uterine arteries and their inhibition by deamino-ethyl-lysine-vasopressin and dea- mino-ethyl-oxytocin, Br. J. Obstet. Gynaecol., 90:732. 5. Vilhardt, H., ... production of fibroblast growth factors fgf-2, fgf -5 , and fgf-18 (30,31), while lens epithelium-derived growth factor pro- moted photoreceptor survival in light-damaged and RCS rats, but not in...

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... including polymer -drug complex sys- tems, erodible microspheres, responsive particulates, in situ gelling systems, ion-exchange systems, and nanoparticles ( 15) . B. Local Injectable Systems When the ... 10 (IL-10) under the control of -myosin heavy chain promoter (-MHC-vIL-10) injected into the graft prolonged allograft survival significantly from 13.9 days to 21.4 days. When - MH...

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... and cytotoxicity of a series of 5 0 -ester prodrugs of 5- iodo-2 0 -deoxyuridine. Pharm. Res. 5: 734–737, 1988. 10 Macha et al. Copyright © 2003 Marcel Dekker, Inc. Ophthalmic Drug Delivery Systems Second Edition, ... effective ophthalmic drug delivery systems, but the knowledge in this field is rapidly expanding. Systems range from simple solutions to novel delivery sy...

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... Ocular drug delivery. Pharmacokinetic considera- tions. Clin. Pharmacokinet., 18: 255 . 6. Lang, J. C., and Stiemke, M. M. Biological barriers to ocular delivery. In: Ocular Therapeutics and Drug Delivery ... models of ocular absorp- tion and disposition. J. Pharm. Biomed. Anal., 16: 951 . 52 . Lindquist, N. G. (1973). Accumulation of drugs on melanin. Acta Radiol. 3 25( Suppl.): 5....

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... adenovirus encoding brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized ... degenerated photoreceptors? Vision Res., 39( 15) : 255 5– 256 7. 71. Peachey, N. S., and Chow, A. Y. (1999). Subretinal implantation of semicon- ductor-based photodiodes: progress and challenge...

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... CD4+ T lymphocyte func- tion. J. Immunol., 160 :52 09 52 12. 2 45. J. Ciesiolka, J. Gorski, and M. Yarus. (19 95) . Selection of an RNA domain that binds Zn 2þ , RNA, 1 :53 8 55 0. 246. M. Sassanfar and ... membrane-active peptides for drug and gene delivery across cellular membranes. Adv. Drug Deliv. Rev., 34:21– 35. 85. E. Wagner. (1999). Application of membrane-active peptides for...

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