Ophthalmic Drug Delivery Systems - part 1 pptx

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... pro- drug and the subsequent hydrolysis of the prodrug to active compound (16 , 99 ,10 0). Prodrugs of pilocarpine (10 1), phenylephrine (10 2 ,10 3), timolol (10 4), and prostaglandin F 2 tromethamine have ... Ocular and sys- temic bioavailability of ophthalmic flurbiprofen. J. Pharmacokin. Biopharm., 12 : 611 . 47. Ding, S., Chen, C C., Salome-Kesslak, R., Tang-Liu, D. D S., and Himme...

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... compounds, including fluorescein (2:6 Â 10 À5 cm/s), fluor- escein glucuronide (4:5 Â 10 À7 cm/s), and dexamethasone sodium m-sulfo- benzoate (4:9 Â 10 À5 cm/s) (1, 9 ,15 17 ,30). All of the reported values ... Therap. 13 (5);445–459, 19 97. 30. Kaiser, R., and Maurice, D. M. The diffusion of fluorescein in the lens. Exp. Eye Res. 3 :15 6 16 5, 19 64. 31. Sebag, J. Aging of the vitreous...

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... applied drugs in the rabbit. Pharm. Res. 15 :18 82 18 87, 19 98. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... J. Pharm. Sci. 64 :13 12 13 16, 19 75. 3. Robinson, J. R., and Mlynek, G. M. Bioadhesive and phase-change polymers for ocular drug delivery. Adv. Drug. Delivery Re...

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... in the rabbit, Pharm. Res., 15 :18 82 18 87. 12 8. Peyman, G. A., and Ganiban, G. J. (19 95). Delivery systems for intraocular routes, Adv. Drug Delivery Rev., 16 :10 7 12 3. 12 9. Geroski, D. H., and Edelhauser, ... Biomaterials., 21: 649–665. 13 1. Peyman, G. A., and Ganiban, G. J. (19 95). Review: Delivery systems for intraocular routes, Adv. Drug Delivery Rev., 16 :...

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... Controlled Rel., 13 :247. 42. Lundin, S., and Atursson, P. (19 90). Absorption of vasopressin analogue, 1- desamino-8-D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO-2, Int. ... Pz-peptide and its effect on the ocular and systemic pharmacokinetics of topically applied drugs in the rabbit, Pharm. Res., 15 :18 82. 93. Chiou, G. C. (19 91) . Systemic delivery...

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... Genet., 11 (1) :49–59. 11 . Bither, P. P., and Berns, L. A. (19 88). Stargardt’s disease: a review of the literature. J. Am. Optom. Assoc., 59(2) :10 6 11 1. Experimental Approaches to Retinal Diseases 5 91 Copyright ... Bhattacharya, S. S. (19 98). Co-injection of adenovirus expressing CTLA4-Ig prolongs adenovirally mediated lacZ repor- ter gene expression in the mouse retina. Gene Ther.,...

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... targeting. Adv. Drug Delivery Rev., 18 :11 5 13 1. 16 7. J. W. Jaroszewski, and J. S. Cohen. (19 91) . Cellular uptake of antisense oli- godeoxynucleotides. Adv. Drug Delivery Rev., 6:235–250. 16 8. D. R. ... Helene. (19 91) . Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation. EM...

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