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Neuroimmunology in Clinical Practice - part 8 ppt

Neuroimmunology in Clinical Practice - part 8 ppt

Neuroimmunology in Clinical Practice - part 8 ppt

... GluR1AGNA-1; ANNA-1,2,3; PCA-2; Ma2; CRMP-5; VGCC (P/Q>N-type)AmphiphysinCRMP-5; ANNA-1; 2, PCA-2CRMP-5; recoverinCRMP-5; VGCC; amphiphysin; ganglionic AChR; VGKC;ANNA-1,2ANNA-1; CRMP-5; ... blockedacetylcholine-induced increase in intracellular freecalcium and inhibited 125I-α-bungarotoxin bind-ing in cells expressing α7nAChR. The authors postulate that these antibodies may act by blocking the ... Ma2;neuropilAGNA-1; ANNA-1,2,3; PCA-2; amphiphysin; CRMP-5;ganglionic AChR; VGCC (P/Q or N); striational; GAD65;EFA6AMa2; ANNA-1CRMP-5VGKCPCA-1,2,Tr; CRMP-5; AGNA-1; ANNA-1,2,3; VGCC(P/Q>N-type);...
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Neuroimmunology in Clinical Practice - part 1 ppt

Neuroimmunology in Clinical Practice - part 1 ppt

... Brannagan III.p. ; cm.Includes bibliographical references and index.ISBN-13: 97 8- 1 -4 05 1-5 84 0-4 (hardback : alk. paper)ISBN-10: 1-4 05 1-5 84 0-9 (hardback : alk. paper) 1. Neuroimmunology. 2. Nervous ... glycoprotein with a single trans-membrane domain and is targeted to axons underly-ing paranodal regions of myelin sheaths in the CNSand PNS (Einheber et al., 1997). This protein partici-pates in ... fields in medicine, hasevolved into a framework of rapidly developing sub-specialties increasingly dependent on technology-driven advances in clinical and basic sciences. Neuroimmunology is a particularly...
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Neuroimmunology in Clinical Practice - part 2 pdf

Neuroimmunology in Clinical Practice - part 2 pdf

... whereasanimals deficient in IL-12 alone develop severe dis-ease. Interleukin-23 induces IL-17 production by Tcells. IL-17 is expressed in brain lesions and appearsto be a regulator of CNS in ammation.T ... four clinical courses that are routinely used in practice (Lublinand Reingold, 1996).This empirical classification, in agreement withnatural history studies, distinguishes relapsing-remitting ... isoelectrofocusing or raised IgG index) orAnother clinical attack involving a different siteDissemination in time, demonstrated by MRI (Box 3.2) orSecond clinical attackDissemination in space,...
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Neuroimmunology in Clinical Practice - part 3 pdf

Neuroimmunology in Clinical Practice - part 3 pdf

... anti-CD40L/-CD154 (IDEC-131); anti-IL-12,anti-CD6; anti-CD3 (OKT3); anti-Vβ5.2/5.3+T cells; anti-CD4; integrin inhibitorsLymphocyte-specific cytoplasmic protein – tyrosine kinase P56lck; zeta-associatedprotein ... 25-year-old male with secondary-progressive MS (a, b, c) showing homogeneouslyenhancing lesions (a) and from a 29-year-old female with relapsing-remitting MS (d, e, f ) showing ring-enhancing ... used in clinical routine practice shouldoperate at a field strength higher than 1.0T. With the introduction of 3T MRI systems into clinical practice, several questions arise, including the com-parison...
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Neuroimmunology in Clinical Practice - part 4 pot

Neuroimmunology in Clinical Practice - part 4 pot

... Progressive Efficacy Clinical Trial ofRecombinant Interferon-beta-1a in MS (SPECTRIMS)Study Group. 2001. Randomized controlled trial of interferon-beta-1a in secondary progressive MS: Clinical results. ... 2006.Interferon-beta-1a slows down progression of brainatrophy in relapsing-remitting multiple sclerosis byreducing predominantly grey matter atrophy pro-gression. Mult Scler, in press.Zivadinov, ... negative in ADEM, may also be positive in a number of ONDsthat may resemble ADEM clinically or radiographic-ally including leukodystrophies, tumors, and infect-ions. CSF myelin basic protein concentration,...
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Neuroimmunology in Clinical Practice - part 5 potx

Neuroimmunology in Clinical Practice - part 5 potx

... T.K. 1 985 .Sequential electrodiagnostic abnormalities in acute in ammatory demyelinating polyradiculoneuro-pathy. Muscle Nerve, 8, 5 28 39Arnason, B.G.W. 1 982 . Acute in ammatory demyelin-ating ... plasmapheresis in acute disseminated (post-infectious) encephalomyelitis. J Clin Apheresis, 7(4),173 –9.Sugita, K., Suzuki, N., Shimizu, N. et al. 1993.Involvement of cytokines in N-methyl-N’-nitro-N-nitrosoguanidine-induced ... identified. Inter-leukin 23 (IL-23) may play an important role in theearly effector phase of immune-mediated peripheralnerve demyelination in EAN, as well as in humanGBS. IL-23 is highly expressed in...
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Neuroimmunology in Clinical Practice - part 6 pdf

Neuroimmunology in Clinical Practice - part 6 pdf

... consistent benefit includeindomethacin, somatostatin analogs, caffeine, ergotalkaloids, and nocturnal desmopressin. L-threo-3, 4-dihydroxyphenylserine is used in the rare but dis-tinctive entity, ... Brain, 81 , 157.Azulay, J.P., Blin, O., Pouget, J. et al. 1994. Intravenousimmunoglobulin treatment in patients with motor-neuron syndromes associated with anti-Gm1 anti-bodies – A double-blind, ... andneuronopathy. Seminars Neurol, 19 98; 18, 7– 18. Barohn, R.J., Kissel, J.T., Warmolts, J.R. and Mendell, J.R.1 989 . Chronic in ammatory demyelinating poly-radiculoneuropathy – Clinical characteristics,...
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Neuroimmunology in Clinical Practice - part 7 pps

Neuroimmunology in Clinical Practice - part 7 pps

... benefits.Cyclosporine A is an immunosupressant that blocksinterleukin-2 activation of T-helper cells by inhibit-ing calcineurin. While a controlled, double-blind clinical trial has shown its effectiveness in ... screening for immunocytochemicalstaining for proteins known to be associated withmuscular dystrophies is appropriate. The main finding in DM is perivascular B-cell-predominant in amma-tion ... dermatomyositis,and inclusion-body myositis. N Engl J Med, 325,1 48798. Dalakas M.C. 2002. Muscle biopsy findings in inflam-matory myopathies. Rheum Dis Clin North Am, 28, 779– 98. Dalakas, M.C. 2004. In ammatory...
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Neuroimmunology in Clinical Practice - part 9 pot

Neuroimmunology in Clinical Practice - part 9 pot

... perivascular in ammation of the adventitia, and intimal prolifera-tion resulting in narrowing of arterial lumina. Laterinvestigators (Kernohan and Woltman, 19 38) sum-marized the clinical and ... of IL-1, IL-6, and IL -8 ; expression of cell adhesion molecules (CAMs), namely integrins,selectins, and the immunoglobulin superfamily mole-cules (intercellular (ICAM-1), vascular (VCAM-1),platelet-endothelial ... solution using thesame manufacturing method was licensed in 1992.Solvent detergent treatment, including partitioningsteps and incubation at low pH in the final containerhas been effective in the...
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Neuroimmunology in Clinical Practice - part 10 pps

Neuroimmunology in Clinical Practice - part 10 pps

... syndrome 49, 185 8, 2 28 cerebrospinal fluid 186 –7 clinical presentation 185 –6diagnosis 185 imaging 186 pathology 187 treatment 187 beta interferonadverse effects 65 in MS 64–5blood–brain barrier ... disease 83 –7, 106, 107cerebrospinal fluid 84 clinical phenotype 83 –4diagnostic criteria 86 genetics 85 MRI 84 , 84 NMO-IgG biomarker 85 –6pathology 84 –5treatment 86 diabetes mellitus 1323, 4-diaminopyridine ... juxtaparanodal proteins17–19claudin 11 17– 18 claudin 19 18 contactin 18 contactin-associated protein 18 neurofascin 18 19peripheral autonomic neuropathies 142peripheral myelin protein (PMP22) 16plasmapheresisGuillain–Barré...
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