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Neuroimmunology in Clinical Practice - part 7 pps

Neuroimmunology in Clinical Practice - part 7 pps

Neuroimmunology in Clinical Practice - part 7 pps

... screening for immunocytochemicalstaining for proteins known to be associated withmuscular dystrophies is appropriate. The main finding in DM is perivascular B-cell-predominant in amma-tion ... terminal.Guanidine increases calcium within the nerve ter-minal by inhibiting uptake of calcium by subcellularorganelles (Kamenskaya et al., 1 975 ). While guani-dine is occasionally utilized in ... T-helper cells by inhibit-ing calcineurin. While a controlled, double-blind clinical trial has shown its effectiveness in MG(Tindell et al., 1993), significant side effects and druginteractions...
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Neuroimmunology in Clinical Practice - part 10 pps

Neuroimmunology in Clinical Practice - part 10 pps

... vasculopathy230–1innate immunity 3interferon-gamma 5internodal proteins 13– 17 CD9 13myelin-associated glycoprotein13–14myelin-associated oligodendrocytebasic protein 14–15myelin basic protein 14myelin ... 14myelin lipids 19myelin oligodendrocyte glycoprotein15myelin protein zero 15myelin sheath 11, 12myelin and T-lymphocyte protein (MAL) 17 myelitis 47 8acute transverse 105 7 myelopathy 47 8NICP_D01 ... Neuroradiol,12, 73 –6.NICP_C21 03/05/20 07 10:50 AM Page 248Index 261oligodendrocyte-myelin glycoprotein16peripheral myelin protein (PMP22)16proteolipid protein (PLP1) 16– 17 T-lymphocyte maturation-associatedprotein/myelin...
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Neuroimmunology in Clinical Practice - part 1 ppt

Neuroimmunology in Clinical Practice - part 1 ppt

... 04/05/20 07 12:27PM Page 15Foreword Neuroimmunology in Clinical Practice provides a use-ful and comprehensive review of the field of clinical neuroimmunology. In addition to presenting timelyupdates ... that are incor-porated into compact myelin. Interestingly, one ofthe MOBP isoforms (MOBP155) includes tandemrepeats of a proline-rich domain, suggesting it mayinteract with other proteins (Yamamoto ... 04/05/20 07 12:27PM Page 14Neurology, as many other fields in medicine, hasevolved into a framework of rapidly developing sub-specialties increasingly dependent on technology-driven advances in clinical...
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Neuroimmunology in Clinical Practice - part 2 pdf

Neuroimmunology in Clinical Practice - part 2 pdf

... whereasanimals deficient in IL-12 alone develop severe dis-ease. Interleukin-23 induces IL- 17 production by Tcells. IL- 17 is expressed in brain lesions and appearsto be a regulator of CNS in ammation.T ... the BBB and invasion of the brain parenchyma. In both EAE andMS, levels of gelatinase B (MMP-9) and matrilysin(MMP -7 ) are increased in blood, CSF, and brain duringperiods of in ammatory disease ... enhancing MRI lesions. Chemokines form achemo-attractant gradient that is perceived by T cellsand assists their invasion into the CNS. Chemokines,including interferon γ-inducible protein-10...
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Neuroimmunology in Clinical Practice - part 3 pdf

Neuroimmunology in Clinical Practice - part 3 pdf

... cells; anti-CD4; integrin inhibitorsLymphocyte-specific cytoplasmic protein – tyrosine kinase P56lck; zeta-associatedprotein (ZAP ) -7 0; protein kinase C theta; mitogen-activated protein kinase; nuclearfactor ... IN- 1 (anti-Nogo-A mAb)Pyrimadine synthesis inhibitor (teriflunamide); CCI -7 7 9 (ester or sirolimus); FTY720(inhibits T-cell circulation); xaliproden (inhibits cytokine synthesis); statins (induceT-helper-cell ... the high-affinity interleukin-2 receptor, anti-CD25); alemtuzumab (anti-CD52,Campath 1H); rituximab (anti-CD20); anti-CD40L/-CD154 (IDEC-131); anti-IL-12,anti-CD6; anti-CD3 (OKT3); anti-Vβ5.2/5.3+T...
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Neuroimmunology in Clinical Practice - part 4 pot

Neuroimmunology in Clinical Practice - part 4 pot

... 2006.Interferon-beta-1a slows down progression of brainatrophy in relapsing-remitting multiple sclerosis byreducing predominantly grey matter atrophy pro-gression. Mult Scler, in press.Zivadinov, ... chain complex. Cell, 57, 1095–100.Secondary Progressive Efficacy Clinical Trial ofRecombinant Interferon-beta-1a in MS (SPECTRIMS)Study Group. 2001. Randomized controlled trial of interferon-beta-1a ... positive in a number of ONDsthat may resemble ADEM clinically or radiographic-ally including leukodystrophies, tumors, and infect-ions. CSF myelin basic protein concentration, usuallypositive in...
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Neuroimmunology in Clinical Practice - part 5 potx

Neuroimmunology in Clinical Practice - part 5 potx

... Suzuki, N., Shimizu, N. et al. 1993.Involvement of cytokines in N-methyl-N’-nitro-N-nitrosoguanidine-induced plasminogen activatoractivity in acute disseminated encephalomyelitis andmultiple ... identified. Inter-leukin 23 (IL-23) may play an important role in theearly effector phase of immune-mediated peripheralnerve demyelination in EAN, as well as in humanGBS. IL-23 is highly expressed in ... are in ammatory, traumatic, or vascular. In children, post-infectious/post-vaccination in am-matory myelitis is a particularly important category.These cases are often a form of ADEM, including...
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Neuroimmunology in Clinical Practice - part 6 pdf

Neuroimmunology in Clinical Practice - part 6 pdf

... consistent benefit includeindomethacin, somatostatin analogs, caffeine, ergotalkaloids, and nocturnal desmopressin. L-threo-3, 4-dihydroxyphenylserine is used in the rare but dis-tinctive entity, ... Marmiroli, P., Baldini, L. et al. 19 87. Peripheral neuropathy in macroglobulinemia –Incidence and antigen-specificity of M-proteins.Neurology, 37, 1506–14.Oh, S.J. 1 977 . Subacute demyelinating neuropathyresponding ... heart rate increase of 30 beats per minute or rate exceeding 120 and ortho-static complaints within five minutes of standing atsome point in the illness are characteristic and are con-sidered...
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Neuroimmunology in Clinical Practice - part 8 ppt

Neuroimmunology in Clinical Practice - part 8 ppt

... GluR1AGNA-1; ANNA-1,2,3; PCA-2; Ma2; CRMP-5; VGCC (P/Q>N-type)AmphiphysinCRMP-5; ANNA-1; 2, PCA-2CRMP-5; recoverinCRMP-5; VGCC; amphiphysin; ganglionic AChR; VGKC;ANNA-1,2ANNA-1; CRMP-5; ... blockedacetylcholine-induced increase in intracellular freecalcium and inhibited 125I-α-bungarotoxin bind-ing in cells expressing α7nAChR. The authors postulate that these antibodies may act by blocking ... Ma2;neuropilAGNA-1; ANNA-1,2,3; PCA-2; amphiphysin; CRMP-5;ganglionic AChR; VGCC (P/Q or N); striational; GAD65;EFA6AMa2; ANNA-1CRMP-5VGKCPCA-1,2,Tr; CRMP-5; AGNA-1; ANNA-1,2,3; VGCC(P/Q>N-type);...
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Neuroimmunology in Clinical Practice - part 9 pot

Neuroimmunology in Clinical Practice - part 9 pot

... solution using thesame manufacturing method was licensed in 1992.Solvent detergent treatment, including partitioningsteps and incubation at low pH in the final containerhas been effective in the ... and exten-sion into the brain involving veins and arteries ofvarying caliber. The clinicopathological syndromewas delineated and so named for the distinctivepathology (Cravioto and Fegin, 1959). ... perivascular in ammation of the adventitia, and intimal prolifera-tion resulting in narrowing of arterial lumina. Laterinvestigators (Kernohan and Woltman, 1938) sum-marized the clinical and...
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