Fundamentals of Clinical Ophthalmology - part 7 pps

... 5.83E16 7 17 0165 C R ≤−0333 @ 59HzR= 01 @ 370 –400 Hz 20 7. 63E16 −698 038 17 52 Introduction and Background variability from material to material, scatter in the data, and lack of sufficient ... the shape of the Haigh diagram based on the experimental data. The mean stress model predicts a mean stress of 32.5 ksi independent of R for 10 7 cycles at 59 Hz since the model i...

Ngày tải lên: 03/07/2014, 20:20

... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of...

Ngày tải lên: 06/07/2014, 08:20

... 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several hours. ... volume of distribution of lidocaine is reduced. Therefore, lower-than- normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 7) Renal Disease Renal excretion of parent drug and metabolites is generally accomplished by ... in the elderly because of altered pharmacokinetics and pharmacodynamics, the frequent use of multidrug regimens, and concomitant disease. For example, use of long half-life benzodiazepines ... of lidocaine is reduce...

Ngày tải lên: 06/07/2014, 08:20

... target of QT- Chapter 005. Principles of Clinical Pharmacology (Part 9) Transferase Variants One of the most extensively studied phase II polymorphisms is the PM trait for thiopurine S-methyltransferase ... Deficiency of glucose- 6- phosphate dehydrogenase (G6PD), most often in individuals of African or Mediterranean descent, increases risk of hemolytic anemia in re...

Ngày tải lên: 06/07/2014, 08:20

... cimetidine decreases the renal clearance of dofetilide and of procainamide and its active metabolite NAPA. Chapter 005. Principles of Clinical Pharmacology (Part 11) Pharmacokinetic Interactions ... penetration of multiple HIV protease inhibitors (with the attendant risk of facilitating viral replication in a sanctuary site) appears attributable to P- glycoprotein-med...

Ngày tải lên: 06/07/2014, 08:20

... Internal Disease (Part 7) Telangiectasias (Table 5 4-8 ) In order to distinguish the various types of telangiectasias, it is important to examine the shape and configuration of the dilated blood ... of patients with actinically damaged skin and acne rosacea, and they are found on the legs of patients with venous hypertension and essential telangiectasia. Patients with an...

Ngày tải lên: 06/07/2014, 20:20

... gram-positive bacteria and cell-surface products of mycobacteria and spirochetes can interact with CD14 (Fig. 11 4-3 ). Additional molecules, such as MD-2, also participate in the recognition of ... mechanisms of microbial pathogenesis (Fig. 11 4-3 ). One of the best-studied systems involves the interaction of LPS from gram-negative bacteria and the glycosylphosphatidylinos...

Ngày tải lên: 07/07/2014, 04:20

... of telephone and office management of vulvovaginal symptoms has documented the inaccuracy of the former, and comparison of evaluations by nurse-midwives with those by physician- practitioners ... pseudomycelia in up to 80% of C. albicans culture- positive persons with typical symptoms trichomonads seen in 80– 90% of symptomatic patients, less often in the absence of...

Ngày tải lên: 07/07/2014, 15:20