Báo cáo y học: "Targeted analysis of nucleotide and copy number variation by exon capture in allotetraploid wheat genome" pdf

... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain. Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64. Groups of four mice were injected intramuscularly ... first three domains and are present in the inhibitory receptors of Fig. 6. Inhibition of in vitro cytotoxicity of myotoxins I or II by DM64. Cytotoxicity wa...

Ngày tải lên: 21/02/2014, 01:21

... regulation of the JNK gene, but by modulating phos- phorylation of JNKs. Thus, Bag-1 may inhibit apop- tosis by suppressing the expression of Bid and Bad. Bag-1 may also enhance apoptosis by inhibiting ... apoptosis by inhibiting the expression of Bcl-2 and by modulat- ing phosphorylation of JNK. Both mitochondrial and stress-activated apoptosis pathways played imp...

Ngày tải lên: 31/10/2012, 15:12

... Mutational analysis of hCDC4 in AML In this study the common exons 2 to 11 and the three known transcript variants of exon 1 of hCDC4 (Figure 1A) were analyzed by direct DNA sequencing in 35 samples ... protein. Sequence analysis of hCDC4 exon 10 identifies a new intronic SNP During the analysis of exon 10 and adjacent intronic sequences we could for t...

Ngày tải lên: 31/10/2012, 16:49

... extraction and array analysis. For each array sample, the RNA was prepared from the purified thymocytes. The thymocytes were processed by using the RNEasy Mini Kit (Qiagen, Valencia, CA). Quality and ... maturation. With this in mind, we examined the mRNA expression levels of BAFF and APRIL within the thymocytes. These two genes are expressed by cells of lymphoid lineage,...

Ngày tải lên: 03/11/2012, 11:35

... recognized poorly by antip26 antibody. To determine if recognition of p26-ND60 and p26-alpha encoded polypeptides by antibody to p26 was problematic, corresponding cDNA fragments were inserted into pRSETC and ... vitro [66], and disassembly of active units from an oligomeric (storage) state of a-crystallin was proposed, upon structural analysis of aA-crystallin by site-...

Ngày tải lên: 22/02/2014, 04:20

... member of a family of seven isoforms of enzymes involved in protein cross-linking, including prostatic TGase and factor XIII. tTG is a Ca 2+ -dependent ubiquitous intracellular enzyme that catalyzes ... encoding amino acidic sequences at the ends of each of the putative four main tTG domains, as outlined by [9] and substantially confirmed by [10], were used to amplify these...

Ngày tải lên: 08/03/2014, 09:20

... had unsubstituted hydroxyl group at C-1, and was mostly present in an a-pyranose form. Acyl 1 ,acyl 2 and acyl 3 residues had hydroxy or acyloxy groups at C-3 ( 13 C signals of C-3 at 69.0–72.4 ... 2-N-(3-O- acyl 4 -acyl 2 )-b-GlcN-(1–6)-2-N-acyl 1 )3-O-acyl 3 -GlcN where acyl 1 ,acyl 2 and acyl 3 are 3-hydroxyhexadecanoic or 3-hy- droxyoctadecanoic acids, acyl 4 is tetradecanoic or...

Ngày tải lên: 08/03/2014, 09:20

... using a fixed delay as the TOCSY mixing time. The spectrum was recorded phase-sensitive by applying TPPI. Two-thousand and forty-eight data points were recorded of 256 experi- ments consisting of ... coupling led to splitting of the corresponding signals in 1 H-, and 13 C-NMR spectroscopy. Table 2. 1 H-NMR chemical shifts (p.p.m.) of deacylated LPS of E. coli strain 2513 (R4...

Ngày tải lên: 08/03/2014, 09:20

... substrate-accessing channel, and their guanidinium and hydroxyl groups, respectively, play crucial roles in the binding of the substrate by interacting with the carboxyl group of the substrate fatty acids ... (characteristic of flavin) was not prominent, with resting rP450foxy similar to the native protein, possibly because of a low flavin content. However, the presence of flav...

Ngày tải lên: 08/03/2014, 22:20

... The binding of the N-terminal fragments of CEACAM1 and CEACAM8 by MS11- OpaB-expressing E. coli (lanes 1 and 2), by E. coli not expressing an Opa protein (lanes 3 and 4), binding of OpaJ129- and ... majority of Opa proteins bind to CEACAM proteins, reviewed by Billker et al. [11]. The binding of OpaB128 and OpaJ129 to CEACAM1 and CEACAM8 was determined, using E. co...

Ngày tải lên: 17/03/2014, 10:20