Báo cáo y học: " Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy" ppsx

... characterized karyotypes, multiple karyotypes from the same individual, and karyotypes that were not randomly selected in the original report. Tumor type and location were used to classify karyotypes into ... karyotypes by choosing only the first well-defined karyotype it contained. In case of multiple karyotypes from the same patient (’case’ in the Mitelman Database), on...

Ngày tải lên: 09/08/2014, 23:20

... attention on the interferon (IFN) pathway in systemic lupus erythematosus (SLE) [3–6]. Analysis of microarray data A statistical analysis of appropriately normalized micro- array data is as important ... microarrays raises the profile of IFN as a pathogenic mediator of the myriad alterations to the immune system seen in SLE. In view of the important effects of IFN on i...

Ngày tải lên: 09/08/2014, 01:23

... against this pro-inflammatory cytokine. Interestingly in our PLCH patients this mechanism was down-regulated. The results of our proteome analysis of PLCH BAL suggested the involvement of some ... phosphorylase, pyruvate kinase isozymes, fibrinogen gamma chain, alpha 1B glycoprotein and actin cytoplasmic 1 were identified. BAL proteome analysis of PLCH patients also revealed...

Ngày tải lên: 10/08/2014, 09:22

... [25,32]. Pinealectomy procedure did not result in pronounced myelin degenera- tion as seen in the photochemically induced ischemic injury of sciatic nerve [33-35]. Increasing of nerve fiber myelin sheath ... Embryology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey, 4 Department of Anatomy, Ondokuz Mayıs University School of Medicine, Samsun, Turkey, 5 Ondokuz M...

Ngày tải lên: 10/08/2014, 10:20

... alive generally remained well [2,3]. In a controlled setting vaginal delivery is usually safe and early forceps delivery or vacuum extraction should be con- sidered to prevent any rise in portal ... Her abdominal examination showed splenomegaly (to the level of the umbilicus) and moder- ate ascities. There was no clinical evidence of portosys- temic encephalopathy. Her pulmonary, c...

Ngày tải lên: 11/08/2014, 10:23

... ap- proach to identify key molecules in the course of hy- poxia-induced apoptotic pathways. Such analysis of trophoblastic cells will, in the near future, yield in- sights into the mechanisms of preeclampsia ... accom- panied by villous hypoxia, characterized by dimin- ished syncytial differentiation, syncytial knots, and prominent cytotrophoblasts [1]. Hypoxia is known to...

Ngày tải lên: 31/10/2012, 15:12

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... confirmed by sequencing DNA samples of 51 healthy individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in s...

Ngày tải lên: 31/10/2012, 16:49

... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte ... compared to the young by real-time RT-PCR (Figure 5). These genes thus may be a contrib- uting factor to the increase in B cells, both in total number and in maturity, wi...

Ngày tải lên: 03/11/2012, 11:35

... DM64 binds to the myotoxins through a myotoxic/ cytolytic site distinct from the catalytic site, as already described for the inhibition of myotoxicity by heparin [44]. At least in the case of B. ... of the myotoxin and negatively charged groups in the membrane seem to be involved. After this initial binding, myotoxins penetrate the bilayer by a hydrophobic interaction mediate...

Ngày tải lên: 21/02/2014, 01:21

... [66], and disassembly of active units from an oligomeric (storage) state of a-crystallin was proposed, upon structural analysis of aA-crystallin by site- directed spin labelling, as a model for ... Mchaourab, H.S. (1999) Folding pattern of the a-crystallin domain in aA-crystallin determined by site-directed spin labelling. J. Mol. B iol. 294, 561–577. 68. To ¨ ro ¨ k, Z., Goloub...

Ngày tải lên: 22/02/2014, 04:20