single nucleotide polymorphism microarray analysis of genetic alterations in cancer
báo cáo khoa học: " Identification of Single Nucleotide Polymorphisms and analysis of Linkage Disequilibrium in sunflower elite inbred lines using the candidate gene approach" docx
... Oilseed maintainer Oilseed maintainer Oilseed maintainer Non-oilseed maintainer Oilseed maintainer Oilseed maintainer Oilseed maintainer Oilseed maintainer Oilseed maintainer Oilseed maintainer Oilseed ... Klein × Local (a pool of local varieties of INTA Pergamino breeding program including "Guayacán INTA", "Charata INTA") × "Manfredi" (a pool of varieties from INTA Manfredi breeding program including ... genetics via LD mapping is an emerging field of genetic mapping that has the potential to reach resolution to the level of individual genes (alleles) underlying quantitative traits A Single Nucleotide...
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detection and analysis of genetic alterations
... Schematic illustration of the different steps involved in genetic analysis of single cells from tissue sections 37 Detection and analysis of genetic alterations in normal skin and skin tumours Applications ... and analysis of genetic alterations in normal skin and skin tumours containing an inherent p53 mutation affecting different alleles, were sequenced Sequencing was carried out using dye terminators ... resulting in a more intricate, and thus more easily influenced folding of the strands (Highsmith, 1999) Detection and analysis of genetic alterations in normal skin and skin tumours The detection of...
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ANALYSIS OF GENETIC VARIATION IN ANIMALS pdf
... with inbreeding coefficients in both populations and interpopulations 30 Analysis of Genetic Variation in Animals The inbreeding coefficient of the whole population (FIT = Factor of Inbreeding in ... analysis is done by individual genetic profiling (genetic fingerprinting), determining the interrelations between different individuals and evaluating their allele frequency in populations Microsatellite ... Characterization of 37 breed-specific single- nucleotide polymorphisms in sheep Journal of Heredity 97: 531 Pariset, L et al 2006b Characterization of single nucleotide polymorphisms in sheep and...
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Báo cáo sinh học: "A global analysis of genetic interactions in Caenorhabditis elegans" doc
... purine metabolism (0.0042) L carbohydrate metabolism (0.00073) M Coexpression Lehner genetic interaction Protein-protein interaction Query interaction Fine genetic interaction SGI genetic interaction ... linked by seven SGI interactions to the bar-1 query gene, 11 fine genetic interactions, 36 co-phenotype links, three coexpression links, and one protein-protein interaction link To further investigate ... co-classified interacting pairs in V)/(number of possible co-classified pairs) and Precision (V) = (number of co-classified interacting pairs in V)/(number of interacting pairs in V) We estimated...
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Báo cáo y học: "Microarray analysis of gene expression in lupus" ppt
... galactoside-binding, soluble, binding protein 3.8 Up IL1RN Interleukin-1 receptor antagonist 3.5 Up APOBEC3B Phorbolin 1-like 2.0 Up RGS1 Regulator of G-protein signaling 1.8 Up AGRN Agrin > 71.2 ... among the IFN-induced genes overexpressed in the JDM muscle samples Increased expression of several genes, including G1P3 (encoding IFN-induced 6-16) and CDKN1A (p21 cyclin kinase inhibitor), were ... genes in data derived from multiple laboratories using distinct microarrays raises the profile of IFN as a pathogenic mediator of the myriad alterations to the immune system seen in SLE In view of...
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Báo cáo y học: "New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model" potx
... An increase in PAI-1 suppresses the generation of plasmin resulting in hypofibrinolysis and a relative hypercoagulable state [1] Decreased fibrinolytic activity, which may be a consequence of increased ... NM_031590 WNT1 inducible signaling pathway protein 0.0105 + 1.67 NM_012587 integrin binding sialoprotein 0.0276 + 1.66 NM_053816 calcitonin receptor 0.0316 + 1.63 NM_013191 S100 protein, beta polypeptide, ... viable cells expressing these molecules in comparison to G2 Differences could also be explained in that gene expression analysis findings are supportive of a result effect indicating steroid treatment...
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Báo cáo y học: "Microarray analysis of microRNA expression in the developing mammalian brain" ppt
... direct labeling of microRNAs using radioactivity instead of a glass microarray and RT-PCR/fluorescent labeling, as we used in our study Despite differences in sample selection as Whole brains from ... a free amino group linked to its 5' terminus through a 6-carbon spacer (IDT) and was printed onto amine-binding slides (CodeLink, Amersham Biosciences) Control probes contained two internal mismatches ... than twofold are shown in five columns corresponding to the five time points Colors indicate relative signal intensities The microRNA expression profile was sorted using a hierarchical clustering...
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Microarray analysis of host transcription in response to infection of arabidopsis thaliana protoplasts by coat protein mutants of TCV and HCRSV
... important roles in interaction with its host Point mutations in the putative calcium-binding site (CBS) or hinge connecting shell and protruding domains of TCV CP appear to alter virus-ion interactions, ... 106 against virion antibody at X 105 in detection of TCV in infected N benthamiana Lanes to 10 contained equal loading of total protein of N benthamiana M: BenchMark® Pre-tained Protein Ladder ... affecting interactions between CP and plant hosts (Lin and Heaton, 1999) Moreover, Nterminus of the TCV CP was shown to be involved in eliciting resistant responses in Di-17 Arabidopsis, suggesting...
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Báo cáo y học: " Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy" ppsx
... any mixed gain-loss pairs We also detected the trisomy of 1q [21], which appeared in all tumor categories in the associations involving gain of chromosome (Figure 2a; Figure S2a-d in Additional ... involved only in expected links (for example, a link between a translocation and a gain/loss of one of its derivative chromosomes; a link between two (two-break) translocations originating from one ... and are often used in verifying the existence of specific aberrations We emphasize that in our analysis we analyzed all types of aberrations identifiable by cytogentic techniques, including translocations,...
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Báo cáo y học: "Translational Medicine and Reliability of Single-Nucleotide Polymorphism Studies: Can We Believe in SNP Reports or Not"
... the proportions of positive and negative studies analysing a determined polymorphisms between the studies examining it within 1-3 polymorphisms versus studies examining the same polymorphism among ... the usefulness of certain polymorphisms as prognostic genetic markers It may also have direct impact in medical research by guiding researchers and funding sources in investigating insignificant ... reasons the number of genetic association studies is increasing rapidly and this trend is expected to accelerate due to the availability of mapped single- nucleotide polymorphisms (SNP) in the human...
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Báo cáo y học: "Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients" potx
... occur in carriers of the risk allele at later stages of the disease An interesting finding of the study presented here is the disproportionately high frequency of the PTPN22 1858T allele in male ... increased frequencies in RA patients The CT and TT genotype was present in 37.9% of patients and 19.2% of healthy controls, resulting in an OR of 2.57 (95% CI 1.85–3.58, p < 0.001) Carriage of ... participated in the design of the study, statistical analysis, interpretation of the results, and writing of the final manuscript Acknowledgements We are grateful to the patients with RA, the control individuals,...
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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
... causing the haplotype association Homozygosity could explain the genetic risk associated with rs729749 The rs726749 SNP is noncoding and located in the beginning of intron in NCF4 Analysis of ... based on findings in animal models The Pia4 locus in rats has been shown to reduce the severity of pristane-induced arthritis (an arthritis model) [20] A single nucleotide polymorphism (SNP) in the ... arguments in favour of subgrouping RA patients, and an analysis of nonstratified samples might conceal a true association In the initial analysis of the genotype frequencies we found indications of...
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Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt
... Medical School of Nanjing University, China The controls had no symptoms or histories of CDH All subjects included in the study were of Han Chinese origin living in and around Nanjing No subjects ... a key role in the aetiology and pathogenesis of CDH To evaluate this possible association, we examined the genetic association of the GDF5 SNP with CDH in people of Han Chinese origin and found ... GH, Zhang LJ, Ji SJ: [Association analysis on the polymorphisms of PCOL2 and Sp1 binding sites of COL1A1 gene and the congenital dislocation of the hip in Chinese population] Zhonghua Yi Xue...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
... epithelium of the ileum and colon with differentiated cells being sloughed off into intestinal lumen staining most vividly (Figure 1A,1B,1C) Examination of the intracellular staining pattern ... epithelium of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining ... it does in macrophages The most intense cytoplasmic staining occurred in the terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin-rich...
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Báo cáo y học: "Natural selection of protein structural and functional properties: a single nucleotide polymorphism perspect" potx
... sequence (CDS) within 70 bp of an exon-intron junction Genes were grouped into bins of nine equal intervals according to the proportion of sequence within 70 bp of an exon-intron junction, and ... We obtained human protein-protein interaction data from the IntAct database [64] and examined how SNP A/S ratios are correlated with the connectivity of proteins in the protein-protein interaction ... SCAN domain PF00059 0.43 58 Lectin C-type domain PF07859 0.42 21 alpha/beta Hydrolase fold PF00048 0.40 23 Small cytokines (intecrine/chemokine), interleukin-8 like PF00105 0.14 38 Zinc finger,...
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Báo cáo y học: "Whole genome sequencing of a single Bos taurus animal for single nucleotide polymorphism discovery" potx
... coding regions Most of them (414) cause a frame-shift in the reading frame of the associated gene, indels lead to single amino acid deletions and were single amino acid insertions Comparison of ... 6,292 SNPs in untranslated regions Additionally, 203 indels were located in coding regions, with almost all of them (201) causing a frame-shift in the corresponding gene The remaining two indels ... Abbreviations Indel: small insertion/deletion event; MAF: minor allele frequency; MALDI-TOF: matrix-assisted laser desorption/ionization time -of- flight; SNP: single nucleotide polymorphism Analysis software...
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Tài liệu Báo cáo khoa học: Fra-1 targets the AP-1 site/2G single nucleotide polymorphism (ETS site) in the MMP-1 promoter docx
... appear unchanged in the presence of the inhibitor (–) Thus, a decrease in the expression of MMP-1 in the presence of PD098059 may be due, at least in part, to a decrease in the binding of transcription ... 1G SNP Although increasing concentrations of PD098059 reduce the binding of complexes to the probe containing the 1G SNP, a more pronounced decrease is observed in the binding of complexes to ... h (Fig 4) The increase in MMP-1 mRNA levels in untreated cultures beginning at h has been observed previously in response to removal of serumcontaining medium [57] This increase in MMP-1 mRNA...
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Báo cáo hóa học: " Genetic analysis of Thailand hantavirus in Bandicota indica trapped in Thailand" pptx
... strain Thai0067 had a homologous substitution of isoleucine to valine at pos 110 of the deduced sequence of the GnGc protein This suggested a strong stabilising selection operating on the protein ... RT-PCR and sequencing, participated also in the genetic analysis and drafting the manuscript VH participated in the study design, trapping and screening of rodents, and drafting the manuscript ... in the study coordination and trapping and screening of rodents HH participated in the study design and coordination and drafting the manuscript AP participated in the study design and coordination,...
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báo cáo hóa học:" Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter" pptx
... mammalian Sin3 co-repressor protein [10,11] The effectiveness of the Sin3 binding domain of Mad in silencing gene expression when fused to DNA binding proteins has been demonstrated in two studies ... DNA binding domain and demonstrated specific inhibition of transcription mediated by binding to AP-1 binding site elements [12] Another group of investigators fused Mad SID to the tetracycline ... follicles in sheep [32] Serpine2 protein levels are elevated in dominant bovine follicles [33], whereas the levels of Serpine2 are lower in ovaries of Foxl2 knockout mice suggesting that the gene is induced...
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Báo cáo y học: " Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis" pdf
... whole joints, but not from a single species of cell, we could not detect the change of gene expression in a single species of cell when the content of this single species of cell was low in the ... expression of serum amyloid proteins, metalloproteinases, chemokines, and cytokines is frequently seen in the joints of patients with RA [27,29], indicating that the gene expression profiles obtained ... from joints After removal of the skin and muscle, portions of the leg containing the knee, ankle, and finger joints were rapidly frozen in liquid nitrogen Frozen joints were homogenized using a...
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