Báo cáo y học: "A statistical framework for modeling gene expression using chromatin features and application to modENCODE datasets" pptx

... A statistical framework for modeling gene expression using chromatin features and application to modENCODE datasets. Genome Biology 2011 12:R15. Submit your next manuscript to BioMed Central and ... Biology 2011, 12:R15 http://genomebiology.com/2011/12/2/R15 Page 3 of 18 MET H O D Open Access A statistical framework for modeling gene expression using...

Ngày tải lên: 09/08/2014, 22:23

... in the yeast regulatory network, relationships between gene proper- ties such as expression and binding status and breast cancer type, and finally using chemogenomics, chemoin- formatics, and functional ... CRIT to ide ntify cr oss patterns connecting small molecule descriptor sensitivities to dis- parate types of systems-wide and transcription factor features to feat...

Ngày tải lên: 09/08/2014, 22:24

... computa- tional tool (OncoSNP) for genomic copy number and LOH pro ling of heterogeneous tumors using SNP arrays. Using formal statistical modeling we are able to jointly consider a number of complex factors ... ce, for any particular cancer sample, the ploidy is generally unknown a priori, maybe a fractional value and varies from one cancer to the next. Methods to tackl...

Ngày tải lên: 09/08/2014, 22:23

... obvious gene candidate, (2) likely gene candidate, (3) possible gene candi- date, (4) unlikely gene candidate and (5) gene without relevance. In addition, the genes that were ranked as high by the ... able to rank candidate genes in fashion similar to human evaluations, gene descriptions for four randomly selected QTL regions (Cia4, Cia10, Cia14 and Cia17) were surveyed...

Ngày tải lên: 09/08/2014, 06:22

... computational biology solutions using R and Bioconductor. In Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Edited by: Gentleman R, Carey V, Huber W, Irizarry R, Dudoit ... models using gene expression and tissue microarray analysis. Cancer Res 2007, 67:32-40. 13. Nuzhdin SV, Wayne ML, Harmon KL, McIntyre LM: Common pattern of evolution of gene...

Ngày tải lên: 09/08/2014, 22:23

... individual and not just standardized plan of treatment for every single patient and all available therapy options should be used, such as immunothe- rapy, surgery or chemotherapy sensibly using cytos- tatic ... N-(2-Aminopropyl)-4-(6-(pyrimidine-2-yl)-1,2,4,5-tetrazine-3-yl)be nzamide 4 4-(6-(Pyrimidine-2-yl)-1,4-dihydro-1,2,4,5-tetrazi ne-3-yl)benzoic acid (3) was prepared from...

Ngày tải lên: 25/10/2012, 11:40

... probability by the transliteration submodel and a low probability by the non-transliteration submodel, and vice versa for non-transliteration pairs. This property is exploited to identify transliterations. In ... They are reduced to 35 and 89 for English/Hindi and English/Arabic respectively. The seed data and the training data used in the semi-supervised system are from dif...

Ngày tải lên: 19/02/2014, 19:20

... of y. x → ∗ y: x is an ancestor of y; x ↔ y: x → y or y → x. x < y: x is to the left of y in T . Definition 1 (Projective Language) (Nivre, 2003) ∀a, b, c ∈ T, a ↔ b and a < c < b imply that ... in (Yamada and Matsumoto, 2003). Our general framework provides insights that allow us to improve their algorithm, and to principally justify some of the algorithmic...

Ngày tải lên: 20/02/2014, 12:20

... order to improve system performance (Och 2003). Recently, a second proposal for automatic evaluation has come from the Automatic Summarization community (Lin and Hovy, 2003), with an automatic ... by Lin and Hovy (2003) (they only differ in the stop-word list they use), our results also confirm the proposal for such metrics to be used for automatic evaluation by the Automa...

Ngày tải lên: 20/02/2014, 16:20

... are generally signaled not only by ungrammaticality, but also by pauses, editing terms, parallelism, etc.; thus an approach specific to speech repairs should perform better than just using ... tation to exclude one or more reparanda. For each reparandum skipped, the parser needs to find an interpretation of what the user started to say. In some cases, what the user started...

Ngày tải lên: 20/02/2014, 19:20