Báo cáo y học: "The role of codon selection in regulation of translation efficiency deduced from synthetic libraries" potx

... Genome Biology 2011, 12:R12 http://genomebiology.com/2011/12/2/R12 Page 3 of 10 RESEARC H Open Access The role of codon selection in regulation of translation efficiency deduced from synthetic libraries Sivan ... capacity of codon selection to affect translation efficiency, particularly since these models ignore codon order that is under tight selection...

Ngày tải lên: 09/08/2014, 22:23

... activation of PP2Ac). PR65/A subunit (3 n M ) increased activation of PP2Ac by poly- L -lysine by approximately 70% and it also increased stimulation of Pph22p by poly- L -lysine another 50%. From ... on phosphorylase phosphatase activity of yeast and mamma- lian PP2Ac poly- L -lysine was added to the purified enzymes. As presented in Fig. 5 a peak of poly- L -lysine- stimulated...

Ngày tải lên: 08/03/2014, 22:20

... glycosylated proteins of about 50–90 kDa. The single polypeptide chain of a kininogen contains three domains resembling family 2 cystatins. Cystatins competitively inhibit the activity of papain- like ... energy to the interaction of cystatin B with cysteine proteases [37]. The sequence of the second binding loop of the related family 1 cystatin, cystatin A, differs appreciably f...

Ngày tải lên: 17/03/2014, 10:20

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, a twofold and fourfold increased V s /V h ratiocomparedtothe wild-type (Table 4). The V s /V h r...

Ngày tải lên: 17/03/2014, 23:20

... & Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. J. Am. Chem Soc. 120, 8410–8416. 15. ... to ligation of the thiol group of coenzyme M. Mutations in His237 or Cys239, which are proposed to be involved in ligating zinc, resulted in an over 90...

Ngày tải lên: 17/03/2014, 23:20

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this ... ternary com- plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to prime substrate oxidation. In the case of DAOCS it has been...

Ngày tải lên: 18/03/2014, 01:20

... allergy. factors influencing development of the microbiota. Ann Med 1999, 31(4):288-92. 15. Kalliomaki M, Isolauri E: Role of intestinal flora in the develop- ment of allergy. Curr Opin Allergy Clin ... The role of the intestinal microflora for the development of the immune system in early childhood. Eur J Nutr 2002, 41(Suppi 1):I32-7. 18. Penders J, et al.: Molecular finger...

Ngày tải lên: 08/08/2014, 21:20

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have studied fracture healing in a...

Ngày tải lên: 09/08/2014, 01:21

... Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ: Post- translational hydroxylation of ankyrin repeats in IkappaB pro- teins by the hypoxia-inducible factor ... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways....

Ngày tải lên: 09/08/2014, 01:22

... consequently lead to increasing inter- est in the role of osteoclasts in local bone erosion that is driven by the hypothesis that synovial pannus makes use Review The role of osteoprotegerin in arthritis Georg ... Collagen-induced arthritis Species Rat Mouse Rat Dose 1 mg/kg/day 6.4 mg/kg/day 3 mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duration...

Ngày tải lên: 09/08/2014, 01:23