Báo cáo y học: "Genetic diversity in India and the inference of Eurasian population expansion" doc

... discovery in Indian populations. (a) Population samples. The number of individuals sampled from each Indian population is shown. (b) The number of SNPs found in HapMap non-Indian and Indian populations. ... populations. (c) The number of SNPs found in south Indian, HapMap GIH, and HapMap non-Indian populations. HapMap non-Indian populations include CEU, CHB, CHD, JPT...

Ngày tải lên: 09/08/2014, 22:23

... ICS therapy in young children with mild asthma may ultimately reduce the peak bone mass that they attain at maturity. A baseline DXA measurement may be appropriate in such patients when they attain ... therapy initiated, the response to the bisphosphonate should be moni- tored by serial DXAexaminations at intervals of about 1 to 3 years. 3 It is not yet known whether the early i...

Ngày tải lên: 08/08/2014, 20:23

... etanercept and 10 with infliximab. BMD trends favoured TNF blockade but were small and non-significant. Serum osteocalcin rose and the resorption marker urinary deoxypyrdinoline decreased. Most of these ... sulphasalazine, antimalarials and injectable gold. Of interest, the manual technique of metacarpal morphometry employed in these three old studies is identical with tha...

Ngày tải lên: 09/08/2014, 10:20

... continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations of inter-individual differences in ... be- cause of higher heterozygosity and tighter linkage disequilibrium with disease-causing mutations. In ad- dition, haplotype analysis offers the advantage of not assuming...

Ngày tải lên: 31/10/2012, 14:59

... studies. The results of their study are slightly different from ours, in that they did not find a significant interaction between the presence of the PTPN22 polymorphism and smoking in determining ... whether they currently smoked and the number of cigarettes smoked per day. From these reports, we calculated pack years of smoking (product of years of smoking and...

Ngày tải lên: 09/08/2014, 10:23

... in which male mice are treated with the alkylating agent ethinyl- nitrosourea, causing point mutations in sperm DNA. Offspring of these mice carry these mutations. By screening thousands of offspring ... exhibited any association in the deCODE study. The difference in the findings probably relates to the low coverage of ESR1 genetic variation in the GENOMOS study,...

Ngày tải lên: 09/08/2014, 10:23

... extinc- tion. The principal cause of the great reduction in population size of up to 80% has been the intense mechanisation of agriculture which took place in Spain during the 60s and the 70s. These ... of the study mainly focused on the topology rather than evolutionary time. Distance data was analysed with the neighbour-joining (NJ) method of clustering [34...

Ngày tải lên: 09/08/2014, 18:21

... integrity of the data and the accuracy of the data analysis. Study concept and design: CJC, LIH. Acquisition of data: CJC, LIH, WPC, YHC, WCL. Analysis and interpretation of data: CJC, LIH. Drafting ... Huang YK, Chen YT, Hsueh YM: Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area. Toxicol Appl Pharmacol 2008, 226:14-21. 19. Hua...

Ngày tải lên: 10/08/2014, 05:21

... protects the cells from TNFa-induced U937 cell apoptosis by maintaining mitochondrial integrity and function [43], and ricin-induced apoptosis of U937 cells by maintaining an intracellular reducing ... improve the clarity of the Cu/Zn-SOD band on Western blotting by increasing the amounts of antibody used; to improve the clarity a higher amount of protein was required fo...

Ngày tải lên: 22/02/2014, 07:20

... context of the emerging hypothesis that variations in TLR function in early life may be implicated in allergic propensity. There is now growing evidence that many of the key pathways involved in subsequent ... to the increased risk of infection 2 but may also be implicated in the increased rates of other forms of chronic inflammatory respiratory disease seen in t...

Ngày tải lên: 08/08/2014, 21:20