β1 genetic polymorphisms in susceptibility and clinical manifestation of sle

... linguistic, and cultural diversity, the population history of India has long intrigued anthropologists and human geneticists [3,12-14,20,34,35] A better understanding of Indian genetic diversity and ... separated into distinct clusters Next, we examined the divergence between Indian and non-Indian populations using pairwise FST estimates In comparing major continental groups, India and Europe have ... The number of individuals sampled from each Indian population is shown (b) The number of SNPs found in HapMap non-Indian and Indian populations (c) The number of SNPs found in south Indian, HapMap...

Ngày tải lên: 09/08/2014, 22:23

... fold increased incidence as compared to normal individuals) because of their inability to repair UV-induced DNA lesions These clinical findings are associated with cellular defects, including ... binding protein heterodimer in damage recognition, because the complex binds damaged DNA with high affinity [43] and can dramatically increase the repair rate of certain DNA adducts, including ... Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain Nature 1990; 348: 73-6 65 Sarasin A An overview of the mechanisms of mutagenesis...

Ngày tải lên: 31/10/2012, 14:59

... polymorphism interacts with heavy cigarette smoking in a multiplicative manner These findings contribute to the growing understanding of how genetic and environmental factors interact in RA pathogenesis, ... development of RA, in particular RF-positive RA, and amount and duration are associated with increased risk [35] We thus investigated potential interactions between the three polymorphisms of interest and ... elevated odds of developing RA in the presence of both factors Kallberg and colleagues [38] recently explored potential geneenvironment and gene-gene interactions in RA susceptibility, combining data...

Ngày tải lên: 09/08/2014, 10:23

... healthy control individuals (316 women and 170 men), who were enrolled at the Center of Physical Examination All individuals included in the study were Han Chinese living in and around Nanjing None ... TXNDC3 SNPs and knee OA susceptibility, we conducted two case-control studies in Han Chinese and Japanese populations and a meta-analysis Materials and methods A population of 955 Chinese individuals ... 99% and 63% power to detect odds ratios of 2.1 and 1.5 in our study TXNDC3 Frequencies of the susceptible T allele of rs4720262 were different between Chinese (9.7% in control individuals) and...

Ngày tải lên: 09/08/2014, 10:23

... residential and occupational histories, drinking water supply, cigarette smoking, alcohol drinking, as well as personal and family history of disease Detailed histories of residency and duration of drinking ... read and approved the final manuscript Competing interests We declare that we have no conflict of interest and none of the funding organization played a role in the design and conducted of this ... drinking and CAE Increased UC incidence was found to be associated with older people, being male and having low education level Education level was inversely associated with the risk of UC in...

Ngày tải lên: 10/08/2014, 05:21

... angiopoietin-1 and angiopoietin-2 concentrations in serum and plasma (a) Angiopoietin-1 (Ang-1) and (b) angiopoietin-2 (Ang-2) concentrations were determined in parallel in serum and in ethylenediamine ... value of circulating Ang-1 and Ang-2 in this cohort of critically ill patients In an ongoing prospective trial we shall try to delineate the prognostic value of Ang-1 and Ang-2 in combination ... class of biomarkers in critically ill patients According to preclinical and clinical validation, circulating Ang-1 and Ang-2 can be reliably assessed by novel immunoassays in the ICU setting Key...

Ngày tải lên: 13/08/2014, 11:22

... Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins may result in misincorporation ... (1) A point mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and decreases ... extrapolation of principles of therapy from adult guidelines, limited clinical information from registries, individual case studies and knowledge of current common clinical practice The following is...

Ngày tải lên: 19/02/2014, 23:20

... organization and polymorphisms of the major allergen Lep d in wild and cultured L destructor mites In addition, the effects of polymorphisms on B and T cell epitopes were evaluated in inhibition ELISA and ... BL21(DE3) pLysS (Invitrogen) for expression Expression of recombinant proteins and immunoblotting Recombinant proteins were expressed as C-terminal tagged hexahistidine fusion proteins using the pET-expression ... present as two distinct isoforms, Lep d 2.01 and Lep d 2.02 differing in 13 amino acids The variants of each isoform differ only in a few amino acids with the exception of Lep d 2.0101a and Lep d 2.0101b,...

Ngày tải lên: 17/03/2014, 09:20

... Banking Trim Size: 9in x 6in Need for Radiation Sterilization of Tissue Grafts ch02 15 contamination originating from the environment and handling Additional handling during processing can cause additional ... depicted in Fig 1, there are four main sources of contaminants during processing and handling prior to sterilization: Raw materials, including procured tissues, chemicals or solutions used, and water ... scrubbing and proper gowning before entering the processing room They should always cover their hair (including beard) and wear a mask, and must not talk or cough during procurement and processing...

Ngày tải lên: 22/03/2014, 20:21

... CPS and O-chain LPS are composed of linear trisaccharide repeating units containing 3-linked 2-acetamido-2-deoxy-D-quinovose, 4-linked 3-[(N-acetyl-L-alanyl) amido]-3-deoxy-D-quinovose and 3-linked ... (GalNAcAcontaining trisaccharide repeating unit) (Fig 4A, inset), based on this ratio about 40% of GalNAcA in both CPS and O-chain polysaccharides was present in the form of a primary amine When ... O-chain containing L-rhamnose, 2-amino-2-deoxy-D-mannose and D-glucose [11], confirming that the novel CPS and O-chain polysaccharide were produced during the 72-h in vivo culture period In addition,...

Ngày tải lên: 23/03/2014, 13:20

... frozen in liquid nitrogen within 30 of resection and stored in the vapor phase of liquid nitrogen Tissue sections were made from each sample, stained with hematoxylin and eosin (H&E), and examined ... analysis of cell lines, the ~47 and ~51 kD forms of LRG1 protein were present in both ovarian cancer and NOSE cell lines (Figure 3B); the predominant form detected in all cases was 47 kD Interestingly, ... representing LRG1 (NCBI: gi|4712536) with m/z of +2 and +3 were included in the method Database Searching MS/MS samples were analyzed using SEQUEST (ThermoFinnigan, San Jose, CA) and X! Tandem http://www...

Ngày tải lên: 20/06/2014, 07:20

... involving mobile-charged species in terms of the Maxwell-Wagner relaxation [5] Internal interfaces in the polycrystalline CCTO give rise to the polarization in the insulating grain boundary and ... microstructure consisting of coarse grains (average grain size of approximately 20 µm) and fine grains (average grain size of approximately µm) located around the coarse grains This characteristic indicates ... mixture of these powders was ground for 24 h in ethanol using zirconia grinding media The suspension was then dried and subsequently calcined at 900°C for h with a heating rate of °C/min The calcined...

Ngày tải lên: 20/06/2014, 23:20

... Hisamuddin NAR and Suhailan M: Evaluation of the diagnostic indices and clinical utility of qualitative cardiodetect®® test kit in diagnosis of ami within 12 hours of onset of chest pain in the ... for the definition of AMI includes a combination of two out of three characteristics composed of clinical history, a rise and fall of cardiac biomarkers, and ECG changes Despite being guided ... http://www.intjem.com/content/4/1/67 Page of Figure Flow chart of the study 24 h of onset of chest pain Figure shows the initial ECG findings in the ED The majority of patients (72.5%) in this study...

Ngày tải lên: 20/06/2014, 23:20

... (s.c.) injections in the flank with × 106 cells in 0.2 mL of media containing 20% Matrigel ™(Becton Dickinson, Bedford, MA, USA) or intraperitoneal (i.p.) injections of × 10 cells in mL of media ... containing Mg+2 and Ca+2 was added to each well of a 96-well plate Following an overnight incubation at 4°C, the solution was removed and 1% bovine serum albumin (BSA) in phosphate-buffered saline ... radiolabelings TN performed PET imaging and analysis MWB synthesized the chelate and participated in the design of the studies DEM conceived of and coordinated the studies and assisted with the in vivo...

Ngày tải lên: 21/06/2014, 02:20

... involving mobile-charged species in terms of the Maxwell-Wagner relaxation [5] Internal interfaces in the polycrystalline CCTO give rise to the polarization in the insulating grain boundary and ... microstructure consisting of coarse grains (average grain size of approximately 20 µm) and fine grains (average grain size of approximately µm) located around the coarse grains This characteristic indicates ... mixture of these powders was ground for 24 h in ethanol using zirconia grinding media The suspension was then dried and subsequently calcined at 900°C for h with a heating rate of °C/min The calcined...

Ngày tải lên: 21/06/2014, 17:20

... involving mobile-charged species in terms of the Maxwell-Wagner relaxation [5] Internal interfaces in the polycrystalline CCTO give rise to the polarization in the insulating grain boundary and ... microstructure consisting of coarse grains (average grain size of approximately 20 µm) and fine grains (average grain size of approximately µm) located around the coarse grains This characteristic indicates ... mixture of these powders was ground for 24 h in ethanol using zirconia grinding media The suspension was then dried and subsequently calcined at 900°C for h with a heating rate of °C/min The calcined...

Ngày tải lên: 21/06/2014, 17:20

... Role of B vitamins and enzymes B vitamins function as coenzymes in the synthesis of purines and thymidylate during normal DNA synthesis Diminished levels of these vitamins may result in misincorporation ... (1) A point mutation in the coding region for the 5,10-MTHFR binding site (C677T), leading to the substitution of an alanine to a valine effectively increases homocysteine levels increase and decreases ... extrapolation of principles of therapy from adult guidelines, limited clinical information from registries, individual case studies and knowledge of current common clinical practice The following is...

Ngày tải lên: 27/06/2014, 09:20

... difference of the prevalence between clinically normal and abnormal dogs [57] In spite of higher prevalence in clinically abnormal dogs, rate of showing positive urease activity within one hour in clinically ... clinically healthy uninfected dogs (Urease test negative, PCR positive and had not clinically abnormal gastrointestinal signs) were embedded in paraffin, sectioned and stained with hematoxylin ... Cloning Kit (Invitrogen, U.S.A.) and the plasmids containing correct inserts were analysed Histo pa th olog ic e x am in atio n For evaluating the relation of Helicobacter spp infection and clinical...

Ngày tải lên: 07/08/2014, 15:20

... Taylor and colleagues performed retrospective analysis of the relationship between GP of the b2 receptor and clinical outcomes in a placebo-controlled, crossover trial examining the use of regularly ... to aid in choosing the most appropriate therapy As clinicians attempting to stay current in the evolving science of asthma, we must continue to follow the very exciting literature regarding potential ... 2-adrenoreceptor and response to albuterol in children with and without a history of wheezing J Clin Invest 1997;100:3184–8 Israel E, Drazen JM, Liggett SB, et al The effect of polymorphisms of the beta2-adrenergic...

Ngày tải lên: 08/08/2014, 21:20

... uncoupling of inflammation and joint remodeling in a mouse model of spondyloarthritis Arthritis Rheum 2007, 56:489-497 van der Heijde D, Landewe R, Einstein S, Ory P, Vosse D, Ni L, Lin SL, Tsuji ... continuous or relapsing inflammation [3] In early disease without definite radiographic changes, active inflammation of sacroiliac (SI) joints can normally be visualized using MRI technology Clinical ... or absence of these criteria in patients presenting with chronic back pain and a suspected diagnosis of axial SpA and which can also be used in daily clinical practice [3] Because of the relatively...

Ngày tải lên: 09/08/2014, 01:22