Intraocular Drug DelIvery - part 10 docx

... appro- ximately 12 months, lifelong anti-CMV therapy was required and HAART was not readily available. With the introduction of HAART, which can improve imm- une function in AIDS, long-term anti-CMV ... 71 Oligonucleotides, 75 Ophthalmoscopy, 100 , 102 , 104 Optic nerve crush model, 44 Optic nerve transection, 46 Optic neurotomy radial, 313–314 Optical coherence tomography (OCT), 102 ,...

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... eyes), 42 eyes were available for follow-up at the three-year visit. Of these eyes, 10 (24%) gained two or more lines of visual acuity at the three-year follow-up. Twenty eyes (48%) remained within ... 1996; 103 :2099– 2104 . 28. Jonas JB, Hayler JK, Panda-Jonas S. Intravitreal injection of crystalline cortisone as adjunc- tive treatment of proliferative vitreoretinopathy. Br J Ophthalmol...

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... Probes as Sustained-Release Drug Delivery Systems . . . . 216 Microelectromechanical Systems Drug Delivery Devices . . . . 219 References . . . . 222 PART III: LOCAL DRUG DELIVERY APPROACH TO ... mechanisms by which drugs are cleared, and drug delivery for some specific ophthalmic problems. BASIC PRINCIPLES OF DRUG DELIVERY Delivery Rates As a means to predict the propert...

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... phosphorylation by Rhoa-p160ROCK-dependent and -independent mecha- nisms. J Biol Chem 2001; 276 :10, 423 10, 431. 71. Smales C, Ellis M, Baumber R, Hussain N, Desmond H, Staddon JM. Occludin phos- phorylation: ... occlusion (63–65). Application of the EC-SOD mimic, AEOL10113 (a metalloporphyrin cata- lytic antioxidant) [manganese(III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin], Neuropr...

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... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1985 (56). The formula of anecortave acetate is 4,9(11)-pregnadien-17,21-diol-3,20-dione-21-acetate. ... intravitreal drug levels. Pharmacokinetic studies are important in the development of local ocular drug delivery. Although a benefit of ocular drug delivery is the ability to achieve hig...

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... cell therapy-based NT-501 intraocular devices. Tissue Eng 2004; 10( 11/12):1617–1622. 128 Tao et al. from minimal swelling to more pronounced vacuolization and disarray. The lower drug dosages ... recovery of scotopic a- and b-wave amplitudes at 1 and 10 days postinjection, when compared with sali ne-injected controls (Fig. 6). Thus, INS37217 markedly improved post- reattachment ERG fu...

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... Opportunities in drug delivery. Drugs 1997; 54(suppl 4):8–14. 32. Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing liposomes for cultured human cells. Exp Cell Res 1987; 171:195–202. Thermal-Sensitive ... developed to target drugs locally in the eye via a light- based mechanism. The method, called laser-ta rgeted delivery (LTD) (1–3), consists of encapsulating a drug in heat-...

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... of intraocular gas on intravitreal drug concentrations using a nondegradable sustained-release device con- taining fluocinolone and 5- uorouracil (27). Intraocular drug concentrations over a 6-week ... conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes. Curr Eye Res 1990; 9 :105 1 105 9. 200 Ambati 14 Nondegradable Intraocular Sustained-R...

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... with 4-week follow-up before any retreatment No. with 12-week follow-up before any retreatment 1 6 10 50, 75, 100 , 150 30 a 22 22 19 b 2 6 10 50, 75, 100 , 150 20 37 28 c 17 d 3 12 10 50, 75, 100 , ... MICRODIALYSIS PROBES AS SUSTAINED-RELEASE DRUG DELIVERY SYSTEMS Description of Drug Delivery System Microdialysis was originally developed to monitor endogenous compounds in t...

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... resorption, and downregulate inflam- matory mediators [including interleukin (IL )-5 , IL-6, IL-8, prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Corticosteroids stabilize ... release over a longer period. Delivery of co-drugs, dexamethasone–5-FU as an implantable, sustained-release pellet, and triamcinolone–5-FU as injectable intravitreal sustained-release suspen...

Ngày tải lên: 09/08/2014, 20:22