Intraocular Drug DelIvery - part 6 ppsx

... Potentially therap eutic intraocular levels of antibiotics (57 63 ), steroids (64 ), and anti-cytomegaloviral d rugs (65 ,66 ), and anti-fungals (67 ) have been achieved via transscleral iontophoresis in ... con- taining fluocinolone and 5- uorouracil (27). Intraocular drug concentrations over a 6- week period were compared in eyes with drug devices that were injected with C 3 F 8...

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... mechanisms by which drugs are cleared, and drug delivery for some specific ophthalmic problems. BASIC PRINCIPLES OF DRUG DELIVERY Delivery Rates As a means to predict the properties of drug delivery systems, ... Issues in Drug Delivery to the Eye 59 Lewis J. Gryziewicz and Scott M. Whitcup Introduction . . . . 59 Drug Development in the United States . . . . 60 References ....

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... cerebral artery occlusion (63 65 ). Application of the EC-SOD mimic, AEOL10113 (a metalloporphyrin cata- lytic antioxidant) [manganese(III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin], Neuroprotection ... occludin-binding proteins: protein kinase C-z, c-Yes, connexin- 26, and p85, the regulatory subunit of phosphatidylinositol 3-kinase (65 ). Occludin may also interact with proteins vi...

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... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1985 ( 56) . The formula of anecortave acetate is 4,9(11)-pregnadien-17,21-diol-3,20-dione-21-acetate. ... effects of anti-inflammatory drugs on interleukin -6 bioactivity. Biol Pharm Bull 2001; 24 (6) :701–703. Antiangiogenic Agents 81 6 Intravitreal Antimicrobials Travis A. Meredith Department...

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... (33). Preclinical studies using another chlorin, mono- L-aspartyl chlorin e6 (NPe6) have been conducted in rabbits and monkeys (34). PDT using Npe6 was performed 1 36 Kim and Miller ECT Neurotrophic Factors ... Deglon N, et al. Intrathecal delivery of CNTF using encapsu- lated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 19 96; 2 :69 6 69 9. 3. Li...

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... RPE6 5-/ -null mutation dog. Invest Ophtahlmol Vis Sci 2003; 44: 166 3– 167 2. 53. Narfstrom K, Katz ML, Ford M, Redmond TM, Rakoczy E, Bragadottir R. In vivo gene therapy in young and adult RPE65 ... Circulation 1 966 ; 33:302–3 16. 31. Allen TM. Liposomes. Opportunities in drug delivery. Drugs 1997; 54(suppl 4):8–14. 32. Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing lipos...

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... Vision Res 1999; 39:2 569 –25 76. 66 . Margalit E, Maia M, Weiland JD, et al. Retinal prosthesis for the blind. Surv Ophthalmol 2002; 47:335–3 56. Nondegradable Intraocular Sustained-Release Devices 225 at ... Thirty- three percen t of verteporfin-treated eyes and 45% of placebo eyes received treatment at the last treatment visit (21-month follow-up) compared with 61 % and 73%, respec- ti...

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... resorption, and downregulate inflam- matory mediators [including interleukin (IL )-5 , IL -6 , IL-8, prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Corticosteroids stabilize ... suggested (68 ). SUSTAINED DELIVERY AN D CO-DRUGS While for some intraocular disorders, such as uveitis or CMV retinitis, long-term (months to years) delivery may be necessary, for PVR...

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... activator or hemo- dilution in ischemic central retinal vein occlusion. Ophthalmologica 1999; 213: 360 – 366 . 55. Hansen LL, Weik J, Schade M, Muller-Stolzenburg N, Wiederholt M. Effect and com- patibility ... Ophthalmol 1990; 74 :66 5 66 9. 58. Luckie AP, Wroblewski JJ, Hamilton P, et al. A randomised prospective study of outpa- tient haemodilution for central retinal vein obstruction. Aust...

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... 335 Gene gun, 157, 160 Gene therapy proof-of-principle, 161 , 165 vector system, 157, 160 – 161 , 165 Gene-deletion experiments, 32 Genetech clinical trials, 73 Genotoxicity tests, 62 Gentamicin, 10–13, ... (PEDF), 160 , 164 Pilocarpine, 6 Plasmapheresis, 312 Plasminogenactivator inhibitor-1 (PAI-1), 80 Platelet-activating factor (PAF), 3 06 Platelet-derived growth factor (PDGF), 29...

Ngày tải lên: 09/08/2014, 20:22