Intraocular Drug DelIvery - part 5 pptx

... Opportunities in drug delivery. Drugs 1997; 54 (suppl 4):8–14. 32. Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing liposomes for cultured human cells. Exp Cell Res 1987; 171:1 95 202. Thermal-Sensitive ... optic nerve and brain after intraocular injection of rAAV. Vision Res 1999; 39: 254 5– 255 3. 37. Larkin DF, Oral HB, Ring CJ, Lemoine R, George AJ. Adenovirus-mediated gen...

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... 2 .5 I2 3.8 2.3 I3 4.2 2.7 Average 4.8 Æ 0.23 2.9 Æ 0. 15 <0.0001 1489 S1 5. 3 3 .5 S2 7 .5 3.3 S3 7 .5 4.0 I1 5. 5 3.7 I2 4 .5 3.2 I3 5. 3 2.7 Average 5. 9 Æ 0.0.29 3.4 Æ 0.14 <0.0001 Abbreviations: ... Protective Effect of NT -5 0 1 on Photoreceptors of rcd1 Dogs Animal # Retina area à Photoreceptor ONL p-value ECT-CNTF treated Not treated 14 85 S1 5. 5 3.0 S2 5. 8 2.7 S3...

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... Spectrum . . . . 350 Antimicrobial Therapy . . . . 350 Injection of Intraocular Corticosteroids . . . . 352 Prognosis . . . . 353 Summary . . . . 353 References . . . . 353 Index . . . . 357 xii Contents on ... Probes as Sustained-Release Drug Delivery Systems . . . . 216 Microelectromechanical Systems Drug Delivery Devices . . . . 219 References . . . . 222 PART III: LOCAL...

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... studies of 5- Fluorouracil from N-1 alkoxycarbonyl prodrugs in silicone oil. Int J Pharm 1996; 132: 243– 250 . 139. Joondeph BC, Peyman GA, Khoobehi B, Yue BY. Liposome-encapsulated 5- uorouracil in ... occlusion (63– 65) . Application of the EC-SOD mimic, AEOL10113 (a metalloporphyrin cata- lytic antioxidant) [manganese(III) meso-tetrakis (N-ethylpyridinium-2-yl) porphyrin], Neuroprotect...

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... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 19 85 (56 ). The formula of anecortave acetate is 4,9(11)-pregnadien-17,21-diol-3,20-dione-21-acetate. ... growth in vitro by increasing the synthesis of plasminogen- activator inhibitor-1 (PAI-1) ( 65) . This in duction of PAI-1 then inhibits u-PA activ- ity, which is essential for the invasive a...

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... of intraocular gas on intravitreal drug concentrations using a nondegradable sustained-release device con- taining fluocinolone and 5- uorouracil (27). Intraocular drug concentrations over a 6-week ... PLGA rod containing 5- uorouracil (12) and a multiple drug delivery implant consisted of three cylindrical segments, each of which contained one of the following drugs: 5- uoro...

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... with 4-week follow-up before any retreatment No. with 12-week follow-up before any retreatment 1 6 10 50 , 75, 100, 150 30 a 22 22 19 b 2 6 10 50 , 75, 100, 150 20 37 28 c 17 d 3 12 10 50 , 75, 100, ... 150 20 37 28 c 17 d 3 12 10 50 , 75, 100, 150 30 19 19 19 4 6 10 50 , 75, 100 15 22 22 11 e 5 6 5 12 .5, 25, 50 10 28 27 f 25 g a Includes two patients in whom light adminis...

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... release over a longer period. Delivery of co-drugs, dexamethasone 5- FU as an implantable, sustained-release pellet, and triamcinolone 5- FU as injectable intravitreal sustained-release suspension, each ... resorption, and downregulate inflam- matory mediators [including interleukin (IL ) -5 , IL-6, IL-8, prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Corticoster...

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... macula-sparing CMV-related reti nal detachment (51 ). In many cases, pars plana vitrectomy with silicone oil retinal tampon ade (or less commonly long-acting intraocular gas) is indicated (44 ,52 ,53 ). ... mediated predominantly by the b-isoform of PKC. There was > 95% inhibition of VEGF-induced permeability after administration of a PKC b-isoform-selective inhibitor (50 ). Studies are...

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... diffusion, 206 FK506, 45 Fluocinolone acetonide device nondegradable, 271–2 75 Fluorescein, 12–14, 104 Fluorescein angiography, 227, 234, 250 , 299, 309 5- Fluorouracil ( 5- FU), 17, 283, 2 85 Fluoroquinolones, ... 92 Fomivirsen, 333–3 35 Food Drug and Cosmetic Act (FD&C Act), 59 Foscarnet, 329–334, 340 Free radicals, 43, 45 46 Fundus, quadrants of, 299 G protein-coupled P2Y, 97...

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