Báo cáo y học: "Genome-wide insights into eukaryotic transcriptional control" doc

... the inter- play between many protein factors. Published: 7 June 2010 doi:10.1186/gb-2010-11-6-305 Cite this article as: Goodrich JA, Kugel JF: Genome-wide insights into eukaryotic transcriptional ... complete redundancy, quantitative redun- dancy, and incongruent redundancy. e latter category was unexpected yet is relatively common and can arise from partial redundancy between two...

Ngày tải lên: 09/08/2014, 20:22

... ade- novirus-mediated csk gene transfer to synoviocytes and osteoclasts. J Clin Invest 1999, 104:137-146. 14. Pap T, Franz JK, Hummel KM, Jeisy E, Gay RE, Gay S: Activation of synovial fibroblasts in rheumatoid ... 277:34679-34691. 13. Takayanagi H, Juji T, Miyazaki T, Iizuka H, Takahashi T, Isshiki M, Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, Nakamura K, Tanaka S: Suppression of a...

Ngày tải lên: 09/08/2014, 01:22

... multiple physiological roles that can be geneti- cally separated. To date, the only defined activity within any region of the TOC1 polypeptide is a nuclear-trafficking signal estab- lished by the ... proteins and modeled separately. A family of 500 models of each module was generated and these were TOC1 and PRR phylogenyFigure 1 TOC1 and PRR phylogeny. UPGMA phylogenetic tree of TOC1/PRR ......

Ngày tải lên: 10/08/2014, 09:20

... be ( a ) ubr4 12 12 12 12 pA+ pA- pA+ pA- HeLa H9 nup155 16 16 16 16 pA+ pA- pA+ pA- H9 HeLa Bimorphic ( b ) znf207 15 15 15 15 pA+ pA- pA+ pA- HeLa H9 Genes HeLa UBR4 WDFY3 NUP155 SFRS18 PDK4 ZKSCAN EIF3A ZRANB1 SF3B2 PHKB ZNF217 H9 Y Y Y Y - Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Chr 1 4 5 6 7 7 10 10 11 16 20 Bimorphic pA+ Y Y Y - Y Y - - - Y Y - - - Y - - Y Y...

Ngày tải lên: 09/08/2014, 22:23

... infections Hypothyroidism Hypoadrenalism, jaundice Pale skin, red hair Hypoglycemia Intestinal dysfunction High/Tall stature Developmental delays Early-onset obesity Hyperphagia Choquet and Meyre Genome ... severe obesity and developmental delay. Nat Neurosci 2004, 7:1187-1189. 36. Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, Keogh JM, Yanovski JA, El Gharbawy A, Han JC, Tung YC, Hodges JR,...

Ngày tải lên: 11/08/2014, 12:20

... study and declaration of anonymity and confidentiality was presented to all participants. After completing the survey participants were given a briefing about the study. Any incomplete surveys ... cognitively self-evaluate and perceive their own level of aware- ness for their health. Lifestyle Q2. How socially active are you? (low- est) 1 10 (highest) Lifestyle Q3. How active are you i...

Ngày tải lên: 26/10/2012, 09:57

... 0.003 0.008 Very low activity N-benzoyl-Val-Gly-Arg-pNA 1.888 0.117 0.062 Very low activity Very low activity N-acetyl-Leu-Glu-His-Asp-pNA No activity No activity No activity N-acetyl-Val-Glu-Ile-Asp-pNA ... mediated by Cys and His forming a cata- lytic dyad. It has been established that the catalytic propensity of a His is highest, followed by a Cys, at the enzyme active site among the 20 na...

Ngày tải lên: 18/02/2014, 16:20

... the catalytic core of the enzyme to arrive at the three dimen- sional organization revealed by the crystal structures (Fig. 1A). The supernumerary subunits and the catalytic subunits of the yeast cytochrome ... [6]. In yeast and higher eukaryotes, cytochrome b is encoded by mito- chondrial DNA, while the remaining subunits of the bc 1 complex are encoded in the nucleus, synthesized by cytosol...

Ngày tải lên: 19/02/2014, 12:20

... from the s oluble f raction b y affinity chromatography using amylose resin. In vitro kinase assays showed that the autophosphorylating ability o f PknA is strictly magnesium/manganese-dependent, ... prokaryotes usually uses His kinases, which autophosphorylate at histidine residues [2]. In eukaryotes, such signalling pathways are mediated by Ser/Thr or Tyr kinases, which autophosphorylate .....

Ngày tải lên: 22/02/2014, 04:20

... and 5% w ⁄ v poly(ethylene glycol) 4000 for ThDP– acetyl CoA–EcODC. Typically, crystals appeared after 3 days of incubation at 8 °C. Data collection Crystals were incubated in cryosolutions containing ... Crystal- lographic snapshots of oxalyl-CoA decarboxylase give insights into catalysis by nonoxidative ThDP-dependent decarboxylases. Structure 15, 853–861. 5 Muller YA, Lindqvist Y, Fur...

Ngày tải lên: 06/03/2014, 11:20