Báo cáo y học: "Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action" pot

... high-quality data relating to drug targets in yeast. We collected two high-quality training sets: an expert-curated set of 83 yeast protein-compound interactions, and yeast homologs of 180 human drug- pro- tein ... properly cited. Method Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action Maureen E Hi...

Ngày tải lên: 09/08/2014, 20:21

... evaluated and con- firmed by western-blot in individual samples of SCZ- DLPFC (Figures 3A and 3C), reinforcing its potential role in SCZ. Phosphatidylethanolamine-binding protein (PEBP1) Phosphatidylethanolamine-binding ... Proteomic analysis of dorsolateral pre-fron- tal cortex indicates the involvement of cytoskeleton, oli- godendrocyte, energy metabolism and new potential...

Ngày tải lên: 11/08/2014, 17:20

... Tsuchiya T, Ohta H, Okawa K, Iwamatsu A, Shimada H, Masuda T, Takamiya Ki: Cloning of chlorophyllase, the key enzyme in chlorophyll degradation: Finding of a lipase motif and the induction by methyl ... synthetase Geranylgeranyl-chlorophy II a dihydrogeranylgeranyl- chlorophy II a Geranylgeranyl reductase PP116501 tetrahydrogeranylgerany l-chlorophy II a Geranylgeranyl reductase...

Ngày tải lên: 11/08/2014, 11:21

... regulation of the JNK gene, but by modulating phos- phorylation of JNKs. Thus, Bag-1 may inhibit apop- tosis by suppressing the expression of Bid and Bad. Bag-1 may also enhance apoptosis by inhibiting ... identify key molecules in the course of hy- poxia-induced apoptotic pathways. Such analysis of trophoblastic cells will, in the near future, yield in- sights into th...

Ngày tải lên: 31/10/2012, 15:12

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 healthy individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite...

Ngày tải lên: 31/10/2012, 16:49

... levels of many of these genes identified in the array analysis. Moreover, Western blot analysis of thymo- cyte lysates also confirmed that IgM increases with age (Figure 3). Flow cytometry analysis ... significantly change with thymocyte age. Interesting, the expression of several immunoglobulin chains were also found to be significantly increased in aged thymocytes. Und...

Ngày tải lên: 03/11/2012, 11:35

... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain. Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64. Groups of four mice were injected intramuscularly ... first three domains and are present in the inhibitory receptors of Fig. 6. Inhibition of in vitro cytotoxicity of myotoxins I or II by DM64. Cytotoxicity was an...

Ngày tải lên: 21/02/2014, 01:21

... determinant of small heat shock/a-crystallin protein function. As a case in point, o ligomers l acking chaperone activity arise from chimeric a-crystallins [63]. Also, insertion of a peptide [41,64] and ... vitro [66], and disassembly of active units from an oligomeric (storage) state of a-crystallin was proposed, upon structural analysis of aA-crystallin by site- directed...

Ngày tải lên: 22/02/2014, 04:20

... a family of seven isoforms of enzymes involved in protein cross-linking, including prostatic TGase and factor XIII. tTG is a Ca 2+ -dependent ubiquitous intracellular enzyme that catalyzes the ... belongs to a family of enzymes that catalyze protein cross-linking reac- tions and is constitutively expressed in many tissues as well as being activated during apoptosis. In a recen...

Ngày tải lên: 08/03/2014, 09:20

... had unsubstituted hydroxyl group at C-1, and was mostly present in an a-pyranose form. Acyl 1 ,acyl 2 and acyl 3 residues had hydroxy or acyloxy groups at C-3 ( 13 C signals of C-3 at 69.0–72.4 ... 2-N-(3-O- acyl 4 -acyl 2 )-b-GlcN-(1–6)-2-N-acyl 1 )3-O-acyl 3 -GlcN where acyl 1 ,acyl 2 and acyl 3 are 3-hydroxyhexadecanoic or 3-hy- droxyoctadecanoic acids, acyl 4 is tetradecanoic or...

Ngày tải lên: 08/03/2014, 09:20