Báo cáo y học: "Genome-wide DNA demethylation in mammals" docx

... activity of MBD4 (methyl-CpG binding domain pro- tein 4), another thymine glycosylase involved in removing T/G mismatches [17]. Most studies in the field of active DNA demethylation are based on ... hormone-dependent demethylation of the CYP27B1 gene, suggesting that cytosine deamination may not necessarily be required for demethylation [17]. Another study argued for a model in...

Ngày tải lên: 09/08/2014, 20:22

... phosphatases play relevant roles in the biology of the yeast (cell integrity, cell c ycle regulation, cation homeostasis, etc) and that they interact with several key signalling pathways. In some cases, ... rcelona, Spain. E-mail: Joaquin.Arino@uab.es Abbreviations: MAP kinase, mitogen activated protein kinase; TOR, target of rapamycin; PP1, type 1 protein phosphatase; PP2A, type 2A prote...

Ngày tải lên: 17/03/2014, 23:20

... tested this intriguing possibility by explor ing DNA methylation in PGCs obtained from Aid -/- embryos. In their technically challenging study (mamma- lian PGCs can be obtained only in small ... by cytosines by base excision repair (BER). Methyl binding domain protein 4 (MBD4) is one of the known thymine glycocylases in vertebrates and it recognizes specifically the product of...

Ngày tải lên: 09/08/2014, 20:21

... Separation of PBMC Subsets and HIV DNA Analay- sis. Because HIV DNA is present in both lympho- cytes and monocytes, we were interested in assessing whether more HIV DNA was in one particular PBMC subset ... peptides, which distinguishes HIV-1 subtype B and E infection in Thai individuals and confirmed by se- quencing, when indicated [19, 20]. Specimens and HIV DNA Assay...

Ngày tải lên: 31/10/2012, 15:34

... cardio- myopathy in Kearns–Sayre syndrome with deficiency of cyto- chrome-c-oxidase in cardiac and skeletal muscle. An enzymehistochemical—ultrammunocytochemical fine structural study in longterm ... rhesus monkey studies. Sections were then obtained using a cryostat and, depending on the study, 100–200 serial, 8–10-lm thick sections were produced. Samples were analyzed by staining every...

Ngày tải lên: 17/03/2014, 23:20

... active in maintaining mitotic synchrony of plasmodia b y playing the mediator between the periodic synthesis of certain proteins and the catalytic competence of DNA po lymerases. Keywords: poly(malic ... NA polymerases a, d,andb-like in the nuclea r e xtract, measured in arbitrary units (staining intensity) by the highly sensitive technique o f photoaffinity labeling. Single types of...

Ngày tải lên: 31/03/2014, 21:21

... methods using the EM algorithm can be improved simply by using more starting points or by looking into alternative starting-point procedures. However, there is Table 4 Percentage of correctly identified ... a competing false motif. Background DNA- binding transcription factors have a crucial role in tran- scriptional regulation, linking nuclear DNA to the transcrip- tional regulatory mac...

Ngày tải lên: 09/08/2014, 20:20

Ngày tải lên: 09/08/2014, 23:20

... important in helping the affected community. International organizations can assist the affected country by providing urgent medical services in proximity to the disaster area, thereby compensating ... pre-hospital medical management during the first days. Methods: The study was performed in 2008; an interview based qualitative study using content analysis. We conducted nineteen intervi...

Ngày tải lên: 25/10/2012, 09:56

... week to 78 years old. Nearly one third of all insertions (n = 22) were made in patients younger than two years. Intraosseous use by age is presented in Table 1. Presenting diagnosis Intraosseous ... Structured training in intraosseous infusion to improve potentially life saving skills in pediatric emergencies - Results of an open prospective national quality development project over 3...

Ngày tải lên: 25/10/2012, 10:02