Báo cáo y học: " Transcriptional regulation of metastatic [Id]entity by KLF17" pdf

... Loss of expression of KLF17 by transcriptional suppression or inactivation by post-translational modification (possibly by phosphorylation or dephosphorylation) leads to transcription of ID1 ... factors might play a role in the regulation of invasion and metastasis in different cancer types. Figure 1 Regulation of ID1 expression by KLF17. ID1 transcription is suppres...

Ngày tải lên: 09/08/2014, 20:20

... differen- tiation in erythroid progenitors. Polycytemia vera is a clonal myeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... development. Regulation of the b-globin tissue- and developmental stage-specific expression ismediatedbyitspromoteraswellasbydistalregulatory Ó FEBS 2002 Transcriptional re...

Ngày tải lên: 08/03/2014, 22:20

... mediated primar- ily by chondrocytes, by synovial fibroblasts and on occa- sion, by osteoclasts [7,10–12]. The interstitial collagens (types I, II and III), are the princi- ple targets of destruction, ... usually produced only by cartilage and bone during development, and by chondro- cytes in osteoarthritis (OA) [6–8]. Expression of MMPs is low in normal cells, and these low lev...

Ngày tải lên: 09/08/2014, 03:24

... telomerase activity was measured by TRAP/EIA cells 3 days later. (C) Telomerase activity after introduction of antisense oligonucleotides into PHA- stimulated lymphocytes. Ficoll-Hypaque isolated lymphocytes ... inhibition of TEP1 function by high concentra- tions of antisense oligonucleotides, telomerase activity was dramatically diminished. Alternatively, hTR and hTERT may play a...

Ngày tải lên: 17/03/2014, 23:20

... (IGF-1) can Figure2 Model of mechanisms of the Osx inhibitory effect on Wnt pathway. Osx negatively controls Wnt pathway by two different mechanisms: activates the expression of Wnt antagonist Dkk1 ... inhibition of Wnt/β-catenin signaling activity by Osx constitutes a possible mechanism for the inhibition by Osx of osteo- blast proliferation. Zhang Journal of Orthopaedic...

Ngày tải lên: 20/06/2014, 04:20

... progression of structural damage of the joint bone structure as measured by X-ray analysis. The RA joint synovial fluid and synovium contain a variety of hematopoeitic cells that are in direct proximity ... T-cell lineages identified by their unique cytokine repertoire, how- ever, is hampered by reality (Figure 1). A subset of Th17 cells defined by their expression of the si...

Ngày tải lên: 09/08/2014, 13:21

... currently not known. The high degree of sequence similarity between the CTE-I and MTE-I genes suggests that they diverged relatively recently by gene duplication, possibly by duplica- tion of an ... aim ofthis studywas to characterize the role of an acyl-CoA thioesterase (ARTISt) and an acyl-CoA synthetase as members of an alternative pathway in the regulation of the intracell...

Ngày tải lên: 08/03/2014, 09:20

... stress by redirect- ing t he synthetic machinery towards the synthesis of s ome enzymes involved in glycolysis or sugar-phosphate metabolism [54]. HydA belongs to a new class of Fe-hydrogenases HydA ... they often catalyze the reduction of pr otons with a high specific activity to yield hydrogen [16]. Interestingly, Fe-hydrogenases were not found in cyanobacteria, the free-living ances...

Ngày tải lên: 08/03/2014, 22:20

... al. [14] proposed a biosynthetic pathway in which cadaverine formed by lysine decarboxylation is subsequently hydroxylated to N-hydroxycadaverine by the protein encoded by desB (Fig. 1) which is ... decarboxylation of lysine by a lysine decarboxylase encoded by the desA gene [8,9]. Lysine decarboxylases occur in different Streptomyces species and are involved in the utilization o...

Ngày tải lên: 16/03/2014, 11:20

... P31 ·2 CAT reporter, which is driven by the IRF-dependent element of the IFN-b gene promoter. This reporter is only weakly inducible by virus alone because of the relatively low affinity of IRF-3/7 for the P31 ... gain of interaction can only be inefficiently mimicked by glutamic (or aspartic) acid substitution. By contrast, phosphorylation of the second set of Ser/Thr resid...

Ngày tải lên: 17/03/2014, 10:20