Báo cáo khoa hoc:" EM-REML estimation of covariance parameters in Gaussian mixed models for longitudinal data analysis" docx

... control was maintained in a standard incubator with 21% O 2 . The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... overexpression, indicating that miR-27 does not play an important role in myogenic differentiation. Taken together, these results illustrate a critical and specific r...

Ngày tải lên: 18/02/2014, 08:20

... 945 The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation Heath Ecroyd and John A. Carver School of Chemistry and ... signifi- cantly increased the chaperone activity of aB-crystallin (84 ± 4%) against this target protein. The effect of Arg-HCl on the...

Ngày tải lên: 18/02/2014, 16:20

... models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the structure of exchanging BS-RNase (1BSR) ... Nter are the C-terminal and N-terminal structural regions, respectively, of the two A and B monomers of the dimeric RNase. The black circle betw...

Ngày tải lên: 19/02/2014, 06:20

... substrate binding sites. In the case of the titin and twitchin kinases, the autoinhibitory sequence acts as a pseudo- substrate, occluding ATP binding and preventing protein substrates from binding ... CaM. However in PhK5 Trp357 is found at the C-terminal end of the peptide. This suggests that either PhK5 might bind with Trp357 in the N-terminal site in CaM, or...

Ngày tải lên: 19/02/2014, 17:20

... (2005) 16 2 516 38 ê 2005 FEBS 16 31 The role of N-glycosylation in the stability, trafficking and GABA- uptake of GABA- transporter 1 Terminal N-glycans facilitate efficient GABA- uptake activity of the GABA ... N-linked oligosaccharide side-chains are important for the GABA transport activity. 1- Deoxymannojirimycin inhibits the GA...

Ngày tải lên: 19/02/2014, 17:20

... Quantitation of channeling in intact E. coli FEBS Journal 272 (2005) 32603269 ê 2005 FEBS 3263 Quantitative estimation of channeling from early glycolytic intermediates to CO 2 in intact Escherichia coli Georgia ... Argininosuccinate synthe- tase and argininosuccinate lyase are localized around mitochondria: an immunocytochemical study. J Cell Biochem 60,...

Ngày tải lên: 19/02/2014, 18:20

... system. 4.1 Data The training set includes 349 clinical notes, with 11,967 assertions of medical problems. The test set includes 477 texts with 18,550 assertions. These assertions were distributed ... the training data to measure the impact of each of the four subsets of features explained in Section 3. Ta- ble 3 shows the cross validation results when cu- mulatively...

Ngày tải lên: 20/02/2014, 05:20

... N N = 2048 N = 128 N = 64 N = 2048 331 Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1

Ngày tải lên: 20/02/2014, 07:20

... level of Mcm expression in HeLa cells and cancer cells from human uterine cervix. Although it remains to be determined how enhanced expression of Mcm proteins affects DNA replication in cancer cells, ... in cancer cells derived from uterine cervix and in HeLa cells. The expression of Mcm genes in growth-arrested cells is induced b...

Ngày tải lên: 20/02/2014, 23:20

... usually infinite. Dynamic models are incomplete models that include only the information needed for an application and to which information can be added. Dynamic models are basically approximations ... Model-theoretic semantics provides a computationally attractive means of representing the semantics of natural language. However, the models used in this formalism are...

Ngày tải lên: 21/02/2014, 20:20

... written text, and it contains significantly more instances of it, includ- ing some types of nonreferential it not found in written text. 3.1 The ICSI Meeting Corpus The ICSI Meeting Corpus (Janin ... available during training or test- ing. With this setting, the classifier achieved a re- call of 55.1%, a precision of 71.9% and a resulting F-measure of 62.4% for the detection...

Ngày tải lên: 22/02/2014, 02:20

... parsing of tree adjoining gram- mars with particular emphasis on the use of shared forests to represent all the parse trees deriving a well-formed string. We show that there are two distinct ... studying tag parsing. The schemes using lig and cfg to represent parses can be seen to underly most of the existing tag parsing algorithms, 1 Introduction We study parsing of...

Ngày tải lên: 22/02/2014, 10:20

... as sources or as sinks for internal fluxes. From a biological point of view, they allow the cell to dispose of excess metabolites by storing them in an inert form. When demand for these metabolites ... – that lipolysis of TAG is a key process during lag and pre-logarithmic growth phases (Fig. 2), and promotes the rapid initiation of growth of quiescent cells exp...

Ngày tải lên: 16/03/2014, 04:20

... repair, and apoptosis itself. Conclusions: The estimation of radiation-induced DNA repair by PFGE may be improved by the use of apoptosis inhibitors. The ability to simultaneously determine DNA ... by the spontaneous DNA breakage in this medium. We investigated the mechanisms of this fragmentation with the principal aim of eliminating it in order to...

Ngày tải lên: 09/08/2014, 09:20

... procedures for implementing the EM algorithm to compute REML estimates of variance covariance components in Gaussian mixed models for longitudinal data analysis. The class of models considered includes ... Vleck L.D., Estimation of the parameters involved in a first-order autoregressive process for contemporary groups, J. Dairy Sci. 76 (1993) 3033–3040. EM-R...

Ngày tải lên: 09/08/2014, 18:21