The principles of toxicology environmental and industrial applications 2nd edition phần 10 pptx

... involving the interaction between the nervous system and the hormones of the endocrine glands. neurofibril One of the delicate threads running in every direction through the cytoplasm of the body of ... development, and sexual maturation; and effects on the mother concern lactation and acceptance of the offspring. resorption The loss of substance in...

Ngày tải lên: 09/08/2014, 16:20

... effective anesthetics, and this property increases with the molecular size. The utility of this property is, however, limited by the irritant effects of ethers, and the fact that they are easily ... variety of industrial and commercial uses. They are used in the production of rubber, plastics, cosmetics, paints and coatings, refrigeration, and foods. They also ar...

Ngày tải lên: 09/08/2014, 16:20

... µg/day of PCP is the SHD, which when divided by the water ingestion rate of 2 L/day of water becomes 174 µg/L.)] If the route of environmental exposure to PCP were via the ingestion of food, then the ... each organ. The rate and site of absorption (organ) also may in turn determine the rate of metabolism and excretion of the chemical. So, changing the r...

Ngày tải lên: 09/08/2014, 16:20

... location of esterases is in the blood (plasma and erythrocytes), and of great concern is the enzyme normally responsible for the hydrolysis of acetylcholine. Blockade of this enzyme is the mode of ... TOXICITY OF THE BLOOD between liver and intestine is also included in the model. These features of the model are choices made by the model developer, and re...

Ngày tải lên: 09/08/2014, 16:20

... hydrophilic substances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. For compounds ... RESPONSES OF THE KIDNEY 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes DERMAL AND OCULAR TOXICOLOGY WILLIAM...

Ngày tải lên: 09/08/2014, 16:20

... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear. However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by P...

Ngày tải lên: 09/08/2014, 16:20

... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are ... the cell and are deleted by various repair mechanisms. Some, however, remain undetected and are passed to daughter cells. The significance of the mutations va...

Ngày tải lên: 09/08/2014, 16:20

... discussed the fundamental concepts of metal toxicity. Because of the large number of metals, their ubiquitous nature, and their chemical and physical diversity, the field of metal toxicology is one of ... shortening of the latency (time to tumor) or the number of tumors at an early age are used, rather than the final tumor incidence measured at the end of...

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... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... (e.g., 10% of the animals responding). Statistical treatment of the data can be used to derive the lower confidence limit estimate of the ED, termed th...

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... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process...

Ngày tải lên: 09/08/2014, 16:20