The principles of toxicology environmental and industrial applications 2nd edition phần 8 pot

... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below the line and to the left ind...

Ngày tải lên: 09/08/2014, 16:20

... References and Suggested Reading 155 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes 157 William R. Salminen and Stephen M. Roberts 8. 1 Skin Histology 157 8. 2 Functions 1 58 8.3 Contact ... Toxicity of the Blood 87 Robert A. Budinsky Jr. 4.1 Hematotoxicity: Basic Concepts and Background 87 4.2 Basic Hematopoiesis: The Formation of Blood Ce...

Ngày tải lên: 09/08/2014, 16:20

... location of esterases is in the blood (plasma and erythrocytes), and of great concern is the enzyme normally responsible for the hydrolysis of acetylcholine. Blockade of this enzyme is the mode of ... TOXICITY OF THE BLOOD between liver and intestine is also included in the model. These features of the model are choices made by the model developer, and re...

Ngày tải lên: 09/08/2014, 16:20

... RESPONSES OF THE KIDNEY 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes DERMAL AND OCULAR TOXICOLOGY WILLIAM F. SALMINEN and STEPHEN M. ROBERTS The skin is the body’s first line of ... hydrophilic substances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the ra...

Ngày tải lên: 09/08/2014, 16:20

... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by Phillip L. Williams, Robert C. James, and Stephen M. ... sense out of the more complex, and less understood issues in female and developmental toxicology. As interest 209 Principles of Toxicology: Environmental...

Ngày tải lên: 09/08/2014, 16:20

... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are ... test the carcinogenic potency of chemicals and mixtures. The most common was the mouse skin model, in which repeated applications of a potential carcinogen...

Ngày tải lên: 09/08/2014, 16:20

... diversity, the field of metal toxicology is one of the broadest areas of health effects research. Metals vary greatly in their physical and chemical properties, and therefore, in their potential ... mice 78 10 23 177 288 88 .5 Rats vs. mice 67 32 36 131 266 74.4 Source: Adapted from Haseman and Huff (1 987 ). 13.7 EMPIRICAL MEASURES OF RELIABILITY OF THE EXTRAPOLAT...

Ngày tải lên: 09/08/2014, 16:20

... Food Chem. 7: 686 – 688 (1959). Gadoth, N., and A. Fisher, “ Late onset of neuromuscular block in organophosphate poisoning,” Ann. Int. Med. 88 : 654–655 (19 78) . Gombe, S., and T. A. Ogada, “Health of men ... TOXIC PROPERTIES OF REPRESENTATIVE ETHERS The ethers (see Figure 16.17) are recognized to have a broad variety of industrial and commercial uses. They are used in t...

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... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process...

Ngày tải lên: 09/08/2014, 16:20

... involving the interaction between the nervous system and the hormones of the endocrine glands. neurofibril One of the delicate threads running in every direction through the cytoplasm of the body of ... development, and sexual maturation; and effects on the mother concern lactation and acceptance of the offspring. resorption The loss of substance in...

Ngày tải lên: 09/08/2014, 16:20