The principles of toxicology environmental and industrial applications 2nd edition phần 6 pps

... discussed the fundamental concepts of metal toxicity. Because of the large number of metals, their ubiquitous nature, and their chemical and physical diversity, the field of metal toxicology is one of ... lymphoma and from melanoma are also increasing. These data were confirmed in the 1999 joint release from the CDC, NCI, and ACS. As awareness of environmental...

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... hydrophilic substances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. For compounds ... RESPONSES OF THE KIDNEY 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes DERMAL AND OCULAR TOXICOLOGY WILLIAM...

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... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear. However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by P...

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... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are ... the cell and are deleted by various repair mechanisms. Some, however, remain undetected and are passed to daughter cells. The significance of the mutations va...

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... 1 General Principles of Toxicology GENERAL PRINCIPLES OF TOXICOLOGY ROBERT C. JAMES, STEPHEN M. ROBERTS, and PHILLIP L. WILLIAMS The intent of this chapter is to provide a concise description of the ... each organ. The rate and site of absorption (organ) also may in turn determine the rate of metabolism and excretion of the chemical. So, changing the ro...

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... location of esterases is in the blood (plasma and erythrocytes), and of great concern is the enzyme normally responsible for the hydrolysis of acetylcholine. Blockade of this enzyme is the mode of ... TOXICITY OF THE BLOOD between liver and intestine is also included in the model. These features of the model are choices made by the model developer, and re...

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... C 20 H 12 252 179 > 360 >1 0.00 162 8.7 1.35 Carbon disulfide 75-15-0 CS 2 76. 1 – 169 1 16 297 1,190 2 .67 1. 26 Dimethylaniline 121 -69 -7 C 6 H 5 N(CH 3 ) 2 121.2 36 378 1 1,450 4.17 0. 96 1,4-Dioxane ... discussion of these processes is beyond the scope of this chapter. The reader is referred to the bibliography at the end of this chapter for further references...

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... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below th...

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... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... (hrs) Concentration (mg/m 3 ) Cumulative exposure (mg/m 3 -hr) Tumor incidence (percent) *Antimony trioxide 12 35 1820 38 69 , 160 27 Carbon black 20 85 7395 6. 0 44,370 2...

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... involving the interaction between the nervous system and the hormones of the endocrine glands. neurofibril One of the delicate threads running in every direction through the cytoplasm of the body of ... development, and sexual maturation; and effects on the mother concern lactation and acceptance of the offspring. resorption The loss of substance in...

Ngày tải lên: 09/08/2014, 16:20