The principles of toxicology environmental and industrial applications 2nd edition phần 5 ppsx

... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are ... the cell and are deleted by various repair mechanisms. Some, however, remain undetected and are passed to daughter cells. The significance of the mutations va...

Ngày tải lên: 09/08/2014, 16:20

... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear. However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by P...

Ngày tải lên: 09/08/2014, 16:20

... 1.3 THE IMPORTANCE OF DOSE AND THE DOSE–RESPONSE RELATIONSHIP 9 where MW is the molecular weight of the chemical (g/mol) and 24 .5 is the amount (liters) of vapor per mole of contaminant at 25 ... References and Suggested Reading 155 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes 157 William R. Salminen and Stephen M. Roberts 8.1 Sk...

Ngày tải lên: 09/08/2014, 16:20

... 120 2 25 2 65 85 Phenobarbital (anticonvulsant) 80 × 4 2 65 130 127 455 155 50 Dexamethasone (glucocorticoid) 100 × 3 2 45 70 80 155 1 25 60 3-Methylcholanthrene d 20 × 4 2 15 1 85 300 155 1 45 90 PCBs ... × 4 1 75 170 1 95 260 2 15 100 5, 6-Naphthoflavone [BNF] 80 × 3 1 65 4 95 250 130 1 85 85 Benzo( a )pyrene d 20 × 4 — 1 65 1 65 110 — — Miconazole (antifung...

Ngày tải lên: 09/08/2014, 16:20

... filtration and tubular secretion are dependent on the concentration of the drug in the plasma, and the rate of reabsorption by the tubules is dependent on the concentration of drug in the urine. The ... enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. For compounds with the same hydr...

Ngày tải lên: 09/08/2014, 16:20

... discussed the fundamental concepts of metal toxicity. Because of the large number of metals, their ubiquitous nature, and their chemical and physical diversity, the field of metal toxicology is one of ... shortening of the latency (time to tumor) or the number of tumors at an early age are used, rather than the final tumor incidence measured at the end of...

Ngày tải lên: 09/08/2014, 16:20

... 74-87-3 CH 3 Cl 50 .5 –144 –12 3,800 15, 200 2. 15 ND a Methylene chloride 75- 09-2 CH 2 Cl 2 62 .5 –139 104 350 13,000 ND 1.33 Trichloroethene 79-01-6 C 2 HCl 3 131.4 –99 189 58 1,100 4 .53 1 .5 Vinyl ... effective anesthetics, and this property increases with the molecular size. The utility of this property is, however, limited by the irritant effects of ethers, and t...

Ngày tải lên: 09/08/2014, 16:20

... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below th...

Ngày tải lên: 09/08/2014, 16:20

... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process...

Ngày tải lên: 09/08/2014, 16:20

... classification of, 5 13 -5 14 occupational and environmental health: advantages and disadvantages, 5 13 -5 14 bias in, 5 19 -52 0 causation issues, 5 12 -5 13 disease and human health effects, 5 15- 5 16 ... involving the interaction between the nervous system and the hormones of the endocrine glands. neurofibril One of the delicate threads running...

Ngày tải lên: 09/08/2014, 16:20