The principles of toxicology environmental and industrial applications 2nd edition phần 4 ppsx
The principles of toxicology environmental and industrial applications 2nd edition phần 4 ppsx
... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear.However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by Phillip L. Williams, Robert C. James, and Stephen M. ... the lung, and these factors alert the phagocytic cells to the location of the agents. The macrophages then engulf them and attempt to ingest them withproteolytic enzymes. An example of a macrophage...
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The principles of toxicology environmental and industrial applications 2nd edition phần 5 ppsx
... 175/223 78 20 /44 45 29 /47 62 25/29 86Mouse/lymphoma 45 / 54 87 31 /44 70 0/5 0 13/29 45 CHO/HGPRT 40 /41 98 — — 1/1 100 — —V79 84/ 1 04 81 — — 3/3 100 — —Drosophila SLRL 77/106 73 4/ 18 22 9/16 60 ... in 64 different ways (4 × 4 × 4 or 4 3). The 20 amino acids and three terminalcodes account for less than half of the available codons, leaving well over 30 codons of the possible 64. The biological ... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are...
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The principles of toxicology environmental and industrial applications 2nd edition phần 1 ppt
... between the workplace and the general community. The EPC can be calculated as follows:EPC = OEL100( 4. 2) = OEL 42 0 The value of 100 is used as an UF and the 4. 2 value is used simply for the ... 1 74 µg/L or 1 74 ppb [(5.8 mg/kg per day × 60 kg) ÷ 1,000 = 348 µg/day of PCP is the SHD, which when divided by the water ingestion rate of 2 L/day of water becomes 1 74 µg/L.)]If the route of environmental ... Eosinophils, and Basophils 91 4. 4 The Lymphoid Series: Lymphocytes (B and T Cells) 94 4.5 Direct Toxicological Effects on the RBC: Impairment of Oxygen Transport and Destruction of the Red Blood...
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The principles of toxicology environmental and industrial applications 2nd edition phần 2 ppt
... location of esterases is in the blood (plasma and erythrocytes), and of great concern is the enzyme normallyresponsible for the hydrolysis of acetylcholine. Blockade of this enzyme is the mode of ... Figure 3-24b.) 48 ABSORPTION, DISTRIBUTION, AND ELIMINATION OF TOXIC AGENTSexcretion of xenobiotics into the urine largely terminates the exposure of the body to the chemical,excretion in the bile ... Whether the increased rate of bile flow will increase the rate of elimination of a compound that is both metabolized and excretedby the liver depends on whether the rate-limiting step is the...
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The principles of toxicology environmental and industrial applications 2nd edition phần 3 pps
... hydrophilicsubstances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. Forcompounds ... permeability and chemical composition of the irritantdetermine the rate of percutaneous penetration and how much chemical reaches the viable layers of the skin. A variety of other factors determine whether ... at the terminal boutons. In this way, a stimulus may travel the entire length of the human body. The electrical impulse is often maintained along the length of the neuron with the aid of the...
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The principles of toxicology environmental and industrial applications 2nd edition phần 6 pps
... shortening of the latency (time to tumor) or the number of tumorsat an early age are used, rather than the final tumor incidence measured at the end of the animals’ lives. The use of positive ... diversity, the field of metal toxicology is one of the broadest areas of health effects research.Metals vary greatly in their physical and chemical properties, and therefore, in their potential ... foods. The committee refers to variousstudies, including the National Health and Nutrition Examination Surveys (NHANES, the recent study of pesticides in the diets of infants and children, and the...
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The principles of toxicology environmental and industrial applications 2nd edition phần 7 pptx
... 56-23-5 CCl 4 153.8 –9 170 91 793 5.32 1.59 Chloroform 67-66-3 CHCl3119 .4 –82 143 160 7,920 4. 12 1 .48 Methyl bromide 74- 83-9 CH3Br 95.0 –137 38 1 ,44 4 900 3.36 1.73 Methyl chloride 74- 87-3 CH3Cl ... effective anesthetics, and thisproperty increases with the molecular size. The utility of this property is, however, limited by the irritanteffects of ethers, and the fact that they are easily ... 36 378 1 1 ,45 0 4. 17 0.96 1 ,4- Dioxane 123-91-1 C 4 H8O288.2 50 213 30 Miscible 3.03 1.03 Ethanol 64- 17-5 C2H5OH 46 .1 –173 173 44 Miscible 1.59 0.79 Ethyl acetate 141 -78-6 C 4 H8O288.1...
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The principles of toxicology environmental and industrial applications 2nd edition phần 8 pot
... justified by the data, and are they consistentwith the current scientific understanding of the test or area of toxicology? •Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below the line and to the left indicate antagonism.From ... sound, certain other characteristics of the experimental animals can influencetoxic responses, and therefore the extrapolation of these responses to humans. Examples include the age of the animal...
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The principles of toxicology environmental and industrial applications 2nd edition phần 9 pdf
... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process. Employees areobligated to themselves and their ... commit the resources, manpower, time, and money to the full implemen-tation of the program. They must also provide the authority and demand accountability for the healthprotection of the employees.Commitment...
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The principles of toxicology environmental and industrial applications 2nd edition phần 10 pptx
... actions, 41 141 3 plant toxins, 4 1 742 3 contact dermatitis, 42 242 3 flowering plants, 41 942 2 mushrooms and fungi, 41 741 9 poisons, toxins, and venoms, 40 9 second messenger toxins, 41 441 5 therapy: ... cytotoxins, 41 4 as drug therapy, 43 143 2 functional value of, 41 1 inflammatory and carcinogenic toxins, 41 5 liver and kidney toxins, 41 341 4 molecular and functional diversity, 4 1 04 11 neurotoxic ... venoms, 42 842 9 fish venoms and toxins, 42 542 6 molhtsc venoms and toxins, 42 742 8 reptiles and amphibians, 42 342 5 toxic marine invertebrates, 42 943 0 carcinogenicity, 275 cardiovascular toxins, 41 3...
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