The principles of toxicology environmental and industrial applications 2nd edition phần 4 ppsx

... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear. However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by P...

Ngày tải lên: 09/08/2014, 16:20

... 175/223 78 20 /44 45 29 /47 62 25/29 86 Mouse/lymphoma 45 / 54 87 31 /44 70 0/5 0 13/29 45 CHO/HGPRT 40 /41 98 — — 1/1 100 — — V79 84/ 1 04 81 — — 3/3 100 — — Drosophila SLRL 77/106 73 4/ 18 22 9/16 60 ... in 64 different ways (4 × 4 × 4 or 4 3 ). The 20 amino acids and three terminal codes account for less than half of the available codons, leaving well over 30 codons...

Ngày tải lên: 09/08/2014, 16:20

... between the workplace and the general community. The EPC can be calculated as follows: EPC = OEL 100 ( 4. 2 ) = OEL 42 0 The value of 100 is used as an UF and the 4. 2 value is used simply for the ... 1 74 µg/L or 1 74 ppb [(5.8 mg/kg per day × 60 kg) ÷ 1,000 = 348 µg/day of PCP is the SHD, which when divided by the water ingestion rate of 2 L/day of wa...

Ngày tải lên: 09/08/2014, 16:20

... location of esterases is in the blood (plasma and erythrocytes), and of great concern is the enzyme normally responsible for the hydrolysis of acetylcholine. Blockade of this enzyme is the mode of ... Figure 3-24b.) 48 ABSORPTION, DISTRIBUTION, AND ELIMINATION OF TOXIC AGENTS excretion of xenobiotics into the urine largely terminates the exposure of the...

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... hydrophilic substances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. For compounds ... permeability and chemical composition of the irritant determine the rate of percutaneous penetration and how much chemical reaches...

Ngày tải lên: 09/08/2014, 16:20

... shortening of the latency (time to tumor) or the number of tumors at an early age are used, rather than the final tumor incidence measured at the end of the animals’ lives. The use of positive ... diversity, the field of metal toxicology is one of the broadest areas of health effects research. Metals vary greatly in their physical and chemical properties, an...

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... 56-23-5 CCl 4 153.8 –9 170 91 793 5.32 1.59 Chloroform 67-66-3 CHCl 3 119 .4 –82 143 160 7,920 4. 12 1 .48 Methyl bromide 74- 83-9 CH 3 Br 95.0 –137 38 1 ,44 4 900 3.36 1.73 Methyl chloride 74- 87-3 CH 3 Cl ... effective anesthetics, and this property increases with the molecular size. The utility of this property is, however, limited by the irritant effects of ethers, an...

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... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below th...

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... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process...

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... actions, 41 141 3 plant toxins, 4 1 742 3 contact dermatitis, 42 242 3 flowering plants, 41 942 2 mushrooms and fungi, 41 741 9 poisons, toxins, and venoms, 40 9 second messenger toxins, 41 441 5 therapy: ... cytotoxins, 41 4 as drug therapy, 43 143 2 functional value of, 41 1 inflammatory and carcinogenic toxins, 41 5 liver and kidney toxins, 41 341 4 molec...

Ngày tải lên: 09/08/2014, 16:20