The principles of toxicology environmental and industrial applications 2nd edition phần 2 ppt
The principles of toxicology environmental and industrial applications 2nd edition phần 2 ppt
... respectively, and k 12 and k 21 are the rate constants for transfer between the two compartments. (Reproduced with permission from O’Flaherty, 1981, Figure 2. 22. ) Figure 2. 9 Plot of the logarithm of the ... × 3 29 0 b 120 120 22 5 26 5 85 Phenobarbital (anticonvulsant) 80 × 4 26 5 130 127 455 155 50 Dexamethasone (glucocorticoid) 100 × 3 24 5 70 80 155 12...
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The principles of toxicology environmental and industrial applications 2nd edition phần 1 ppt
... µg/day of PCP is the SHD, which when divided by the water ingestion rate of 2 L/day of water becomes 174 µg/L.)] If the route of environmental exposure to PCP were via the ingestion of food, then the ... 1.3 THE IMPORTANCE OF DOSE AND THE DOSE–RESPONSE RELATIONSHIP 9 where MW is the molecular weight of the chemical (g/mol) and 24 .5 is the amount (l...
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The principles of toxicology environmental and industrial applications 2nd edition phần 7 pptx
... C 2 H 3 CHO 56.1 – 126 127 21 0 20 8,000 1.94 0.84 Aniline 62- 53-3 C 6 H 5 NH 2 93.1 21 363 0.6 34,000 3 .22 1. 02 Benzene 71-43 -2 C 6 H 6 78.1 42 176 75 1,750 2. 7 0.88 Benzidine 92- 87-5 NH 2 (C 6 H 4 ) 2 NH 2 184.3 ... NH 2 (C 6 H 4 ) 2 NH 2 184.3 23 9 7 52 low 400 6.36 1 .25 Benzo(a)pyrene 50- 32- 8 C 20 H 12 2 52 179 >360 >1 0.001 62 8.7 1.35 C...
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The principles of toxicology environmental and industrial applications 2nd edition phần 10 pptx
... response, 22 8 -23 1 fetal hydantoin syndrome, 22 9 human teratogens, 23 0 methylmercury poisoning, 23 0 -23 1 spontaneous abortion and embryonic loss, 22 5, 22 7 22 8 suspected toxicants and teratogens, ... health and, 5077508 Endocrine disruption: currenl research in, 23 2 -23 5 female reproductive toxicology, 22 2 -22 3 Endocrine feedback: female reproductive tox...
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The principles of toxicology environmental and industrial applications 2nd edition phần 3 pps
... filtration and tubular secretion are dependent on the concentration of the drug in the plasma, and the rate of reabsorption by the tubules is dependent on the concentration of drug in the urine. The ... hydrophilic substances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate...
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The principles of toxicology environmental and industrial applications 2nd edition phần 4 ppsx
... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear. However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by P...
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The principles of toxicology environmental and industrial applications 2nd edition phần 5 ppsx
... protein synthesis, Figure 12. 2 Schematic representation of transcription and translation. 24 2 MUTAGENESIS AND GENETIC TOXICOLOGY One possibility, infidelity or inexact copying of a DNA strand during ... favorable, cells enter the synthesis (S) phase of the cycle, where the entire genome of the cell is replicated during DNA synthesis. Following S phase, cells enter t...
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The principles of toxicology environmental and industrial applications 2nd edition phần 6 pps
... discussed the fundamental concepts of metal toxicity. Because of the large number of metals, their ubiquitous nature, and their chemical and physical diversity, the field of metal toxicology is one of ... lymphoma and from melanoma are also increasing. These data were confirmed in the 1999 joint release from the CDC, NCI, and ACS. As awareness of environmental...
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The principles of toxicology environmental and industrial applications 2nd edition phần 8 pot
... justified by the data, and are they consistent with the current scientific understanding of the test or area of toxicology? • Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below th...
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The principles of toxicology environmental and industrial applications 2nd edition phần 9 pdf
... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... 12. 5 Transportation and public utilities 16.6 1.7 0.3 1 .2 0.3 1 .2 9 .2 2.7 Wholesale and 38.8 4.3 0 .2 2.6 0.3 2. 2 20 .9 8.4 retail trade Finance, insurance, a...
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