The principles of toxicology environmental and industrial applications 2nd edition phần 2 ppt
The principles of toxicology environmental and industrial applications 2nd edition phần 2 ppt
... respectively, and k 12 and k 21 are the rate constants for transfer between the twocompartments. (Reproduced with permission from O’Flaherty, 1981, Figure 2. 22. )Figure 2. 9 Plot of the logarithm of the ... × 3 29 0b 120 120 22 5 26 5 85Phenobarbital (anticonvulsant) 80 × 4 26 5 130 127 455 155 50Dexamethasone (glucocorticoid) 100 × 3 24 5 70 80 155 125 603-Methylcholanthrened 20 × 4 21 5 185 ... of the hepatocyte volume and contains 20 percent of the hepatocyte protein, which houses the bulk of the critical drug metabolizing enzyme activity. (The nonparenchymal cells, including endothelialand...
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The principles of toxicology environmental and industrial applications 2nd edition phần 1 ppt
... µg/day of PCP is the SHD, which when divided by the water ingestion rate of 2 L/day of water becomes 174 µg/L.)]If the route of environmental exposure to PCP were via the ingestion of food, then the ... 1.3 THE IMPORTANCE OF DOSE AND THE DOSE–RESPONSE RELATIONSHIP 9where MW is the molecular weight of the chemical (g/mol) and 24 .5 is the amount (liters) of vaporper mole of contaminant at 25 ... 32 References and Suggested Reading 32 2 Absorption, Distribution, and Elimination of Toxic Agents 35Ellen J. O’Flaherty 2. 1 Toxicology and the Safety and Health Professions 35 2. 2 Transfer across...
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The principles of toxicology environmental and industrial applications 2nd edition phần 7 pptx
... C 2 H3CHO 56.1 – 126 127 21 0 20 8,000 1.94 0.84 Aniline 62- 53-3 C6H5NH 2 93.1 21 363 0.6 34,000 3 .22 1. 02 Benzene 71-43 -2 C6H678.1 42 176 75 1,750 2. 7 0.88 Benzidine 92- 87-5 NH 2 (C6H4) 2 NH 2 184.3 ... NH 2 (C6H4) 2 NH 2 184.3 23 9 7 52 low 400 6.36 1 .25 Benzo(a)pyrene 50- 32- 8 C 20 H 12 2 52 179 >360 >1 0.001 62 8.7 1.35 Carbon disulfide 75-15-0 CS 2 76.1 –169 116 29 7 1,190 2. 67 1 .26 Dimethylaniline ... 98-95-3 C6H5NO 2 123 .1 42 411 0.3 (77°F) 2, 090 4.3 1 .2 Nitromethane 75- 52- 5 CH3NO 2 61.0 20 21 4 28 110,000 2. 11 1.14 Phenol 108-95 -2 C6H5OH 94.1 109 359 0.4 82, 800 3 .24 1.06 Pyridine...
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The principles of toxicology environmental and industrial applications 2nd edition phần 10 pptx
... response, 22 8 -23 1 fetal hydantoin syndrome, 22 9 human teratogens, 23 0 methylmercury poisoning, 23 0 -23 1 spontaneous abortion and embryonic loss, 22 5, 22 7 22 8 suspected toxicants and teratogens, ... health and, 5077508 Endocrine disruption: currenl research in, 23 2 -23 5 female reproductive toxicology, 22 2 -22 3 Endocrine feedback: female reproductive toxicology, 22 1 -22 3 male reproductive toxicology ... toxins and venoms, 426 427 coelentrate (cnidarian) venoms, 428 429 fish venoms and toxins, 425 426 mollusc venoms and toxins, 427 428 reptiles and amphibians, 423 425 toxic marine invertebrates, 429 430...
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The principles of toxicology environmental and industrial applications 2nd edition phần 3 pps
... filtration and tubular secretion are dependent on the concentration of the drugin the plasma, and the rate of reabsorption by the tubules is dependent on the concentration of drug in the urine. The ... hydrophilicsubstances is reduced. Often the skin of lab animals is covered with plastic wrap to enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. Forcompounds ... RESPONSES OF THE KIDNEY8Dermal and Ocular Toxicology: ToxicEffects of the Skin and EyesDERMAL AND OCULAR TOXICOLOGY WILLIAM F. SALMINEN and STEPHEN M. ROBERTS The skin is the body’s first line of...
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The principles of toxicology environmental and industrial applications 2nd edition phần 4 ppsx
... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear.However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by Phillip L. Williams, Robert C. James, and Stephen M. ... Understanding the underlying mechanisms will help make sense out of the more complex, and less understood issues in female and developmental toxicology. As interest 20 9 Principles of Toxicology: Environmental...
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The principles of toxicology environmental and industrial applications 2nd edition phần 5 ppsx
... protein synthesis,Figure 12. 2 Schematic representation of transcription and translation. 24 2 MUTAGENESIS AND GENETIC TOXICOLOGY One possibility, infidelity or inexact copying of a DNA strand during ... favorable, cells enter the synthesis (S) phase of the cycle, where the entire genome of the cell is replicated during DNA synthesis.Following S phase, cells enter the Gap 2 (G 2 ) phase before proceeding ... cytogenetics 40/54 74 24 /44 55 2/ 6 33 20 /29 69In vivo cytogenetics 8/9 89 9/15 60 0/0 — 11/ 12 92 In vitro SCE 100/101 99 31/44 70 0/10 0 13 /29 45In vivo SCE 21 /21 100 10/15 67 0/0 — 5/ 12 42 UDS in hepatocytes...
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The principles of toxicology environmental and industrial applications 2nd edition phần 6 pps
... discussed the fundamental concepts of metal toxicity. Because of the largenumber of metals, their ubiquitous nature, and their chemical and physical diversity, the field of metal toxicology is one of ... lymphoma and from melanoma are also increasing. These data were confirmedin the 1999 joint release from the CDC, NCI, and ACS.As awareness of environmental contamination and the ubiquity of synthetic ... shortening of the latency (time to tumor) or the number of tumorsat an early age are used, rather than the final tumor incidence measured at the end of the animals’ lives. The use of positive...
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The principles of toxicology environmental and industrial applications 2nd edition phần 8 pot
... justified by the data, and are they consistentwith the current scientific understanding of the test or area of toxicology? •Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below the line and to the left indicate antagonism.From ... sound, certain other characteristics of the experimental animals can influencetoxic responses, and therefore the extrapolation of these responses to humans. Examples include the age of the animal...
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The principles of toxicology environmental and industrial applications 2nd edition phần 9 pdf
... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... 12. 5Transportation and public utilities16.6 1.7 0.3 1 .2 0.3 1 .2 9 .2 2.7Wholesale and 38.8 4.3 0 .2 2.6 0.3 2. 2 20 .9 8.4retail tradeFinance, insurance, and real estate15 .2 0.8 <0.1 0.6 <0.1 0.1 12. 0 ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process. Employees areobligated to themselves and their...
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